[Correlation of insulin-like growth factor 1 expression in placenta with DNA methylation and fetal macrosomia]

doi:10.3760/cma.j.issn.1003-9406.2015.01.008

科研成果详情

题名	[Correlation of insulin-like growth factor 1 expression in placenta with DNA methylation and fetal macrosomia]
其他题名	Correlation of insulin-like growth factor 1 expression in placenta with DNA methylation and fetal macrosomia
作者	Jitai, Zhang 1; Kele, Wu 2; Xinyun, Xu 1; Ziwei, Liu 1; Chtmg, Lin 1; Yuhuan, Wang 2; Hongtao, Yan 1; Xinjun, Yang 1
发表日期	2015-02-01
发表期刊	Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 影响因子和分区
语种	英语
原始文献类型	Article
关键词	DNA methylation IGF-1 gene Macrosomia Placenta
其他关键词	Macrosomia ; Placenta ; IGF-1 gene ; DNA methylation
摘要	Objective:To explore the correlation between methylation of insulin-like growth factor 1 (IGF-1) gene promoter and its placenta-specific expression and fetal macrosoma. Methods:One hundred twenty nine healthy pregnant women were recruited between April 2011 and March 2012. Baseline data were collected with self-report questionnaires. Real-time quantitative PCR was used to determine the expression of IGF-1 mRNA in the placenta. Methylation level of the IGF 1 gene was determined with matrix-assisted laser desorption/ionization-time of flight mass spectrometry. Results:The expression of IGF-1 in placenta and its methylation level showed no significant difference between macrosomic fetuses and controls. No linear correlation was found between IGF-1 mRNA expression and methylation level of IGF-1 promoter (r=0.128, P=0.295). IGF-1 promoter region in placenta showed a hypomethylation status. However, a positive correlation was found between IGF-1 expression and birth weight below 4260 g (r=0.264, P=0.022). The expression of IGF-1 mRNA was significantly higher in those with a birth weight below 4260 g, which suggested that placental IGF-1 expression may contribute to increased birth weight. In regard to fetal overgrowth, however, there seemed to be a negative correlation in which placental IGF-1 expression was downregulated to limit fetal overgrowth. Conclusion:No linear correlation was found between placental IGF-1 expression and methylation level of IGF-1 promoter with a hypomethylation status. The contribution of placental IGF-1 expression to birth weight is bidirectional. Increased expression seems to promote fetal growth, while decreased expressions may curb overgrowth, therefore control fetal growth in a relatively normal range.
其他摘要	Objective To explore the correlation between methylation of insulin-like growth factor 1 (IGF-1) gene promoter and its placenta-specific expression and fetal macrosoma. Methods One hundred twenty nine healthy pregnant women were recruited between April 2011 and March 2012. Baseline data were collected with self-report questionnaires. Real-time quantitative PCR was used to determine the expression of IGF-1 mRNA in the placenta. Methylation level of the IGF-1 gene was determined with matrix-assisted laser desorption/ionization-time of flight mass spectrometry. Results The expression of IGF-1 in plac enta and its methylation level showed no significant difference between macrosomic fetuses and controls. No linear correlation was found between IGF-1 mRNA expression and methylation level of IGF-1 promoter (r=0. 128, P= 0. 295). IGF-1 promoter region in placenta showed a hypomethylation status. However a positive correlation was found between IGF-1 expression and birth weight below 4260 g (r = 0. 264,P = 0. 022). The expression of IGF-1 mRNA was significantly higher in those with a birth weight below 4260 g,which suggested that placental IGF-1 expression may contribute to increased birth weight. In regard to fetal overgrowth, however, there seemed to be a negative correlation in which placental IGF-1 expression was downregulated to limit fetal overgrowth. Conclusion No linear correlation was found between placental IGF-1 expression and methylation level of IGF-1 promoter with a hypomethylation status. The contribution of placental IGF-1 expression to birth weight is bidirectional. Increased expression seems to promote fetal growth,while decreased expressions may curb overgrowth, therefore control fetal growth in a relatively normal range.
资助项目	浙江省自然科学基金 ; 国家自然科学基金
出版者	West China University of Medical Sciences
ISSN	1003-9406
卷号	32 期号:1 页码:36-9.
DOI	10.3760/cma.j.issn.1003-9406.2015.01.008
页数	4
收录类别	PUBMED ; SCOPUS ; CSCD ; 万方 ; ISTIC ; PKU ; 北大核心
学科领域	医药、卫生 ; 妇产科学 ; 儿科学
URL	查看原文
CSCD记录号	CSCD:5350309
PubMed ID	25636096
SCOPUSEID	2-s2.0-84929018224
通讯作者地址	[Xinjun, Yang]Department of Preventive Medicine,School of Environmental Science and Public Health,Wenzhou Medical University,Wenzhou, Zhejiang,325035,China
Scopus学科分类	Medicine (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/34622
专题	温州医科大学
通讯作者	Xinjun, Yang
作者单位	1.Department of Preventive Medicine,School of Environmental Science and Public Health,Wenzhou Medical University,Wenzhou, Zhejiang,325035,China; 2.Department of Obstetrics and Gynecology,Yuying Children's Hospital Affiliated,Wenzhou Medical University,Wenzhou, ZheJiang,325027,China
推荐引用方式 GB/T 7714	Jitai, Zhang,Kele, Wu,Xinyun, Xu,et al. [Correlation of insulin-like growth factor 1 expression in placenta with DNA methylation and fetal macrosomia][J]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics,2015,32(1):36-9..
APA	Jitai, Zhang., Kele, Wu., Xinyun, Xu., Ziwei, Liu., Chtmg, Lin., ... & Xinjun, Yang. (2015). [Correlation of insulin-like growth factor 1 expression in placenta with DNA methylation and fetal macrosomia]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 32(1), 36-9..
MLA	Jitai, Zhang,et al."[Correlation of insulin-like growth factor 1 expression in placenta with DNA methylation and fetal macrosomia]".Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 32.1(2015):36-9..