Basic fibroblast growth factor promotes melanocyte migration via activating PI3K/Akt-Rac1-FAK-JNK and ERK signaling pathways

doi:10.1002/iub.1531

科研成果详情

题名	Basic fibroblast growth factor promotes melanocyte migration via activating PI3K/Akt-Rac1-FAK-JNK and ERK signaling pathways
作者	Shi, Hongxue1; Lin, Beibei1; Huang, Yan 1; Wu, Jiang1; Zhang, Hongyu1; Lin, Cai 2; Wang, Zhouguang1; Zhu, Jingjing 1; Zhao, Yingzhen 1; Fu, Xiaobing 2; Lou, Zhencai 3; Li, Xiaokun1; Xiao, Jian1
发表日期	2016-09
发表期刊	IUBMB LIFE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	melanocytes basic fibroblast growth factor migration Rac-1
其他关键词	CELLS IN-VITRO ; BFGF PROMOTES ; STIMULATES PROLIFERATION ; VITILIGO ; RAC1 ; FAK ; ADHESION ; ULTRAVIOLET ; CDC42 ; EPIDEMIOLOGY
摘要	Vitiligo is a depigmentation disorder characterized by loss of functional melanocytes of the skin epidermis. The pathogenesis of vitiligo remains elusive. The purpose of this study is to investigate the effects of basic fibroblast growth factor (bFGF) on melanocyte migration, including its biochemical mechanism using transwell assay in vitro. We found that melanocyte treated with bFGF showed a significant increase in migration and cytoskeletal rearrangement. These changes were associated with increased activation of PI3K/Akt, Rac1, FAK, JNK, and ERK. Likewise, reduction of PI3K/Akt, Rac1, FAK, JNK, and ERK activity using selective inhibitors or siRNA was associated with impediment of bFGF-induced melanocyte migration. In addition, activity of Rac1, FAK, and JNK was reduced in cells in which PI3K/Akt was inhibited, activity of FAK and JNK was reduced in cells in which the Rac1 was inhibited, and activity of JNK was reduced in cells in which the FAK was inhibited. Collectively, these data demonstrate that bFGF facilitated melanocyte migration via PI3K/Akt-Rac1-FAK-JNK and ERK signaling pathways. (c) 2016 IUBMB Life, 68(9):735-747, 2016
资助项目	Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents; National Natural Science Funding of ChinaNational Natural Science Foundation of China (NSFC) [81372112, 81372064, 81302775, 81472165]; Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [Y14H150023, Y14H090062, LY13H030008, LY14H150008]; State Key Basic Research Development Program [2012CB518105]; Zhejiang Provincial Project of Key Group [2010R50042]; Medical Scientific Research Foundation of Zhejiang Province [2016KYB207]
出版者	WILEY
出版地	HOBOKEN
ISSN	1521-6543
EISSN	1521-6551
卷号	68 期号:9 页码:735-747
DOI	10.1002/iub.1531
页数	13
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS记录号	WOS:000383571700007
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	27350596
SCOPUSEID	2-s2.0-84983233429
通讯作者地址	[Lou, Zhencai]Department of Otorhinolaryngology,The Affiliated YiWu Hospital,Wenzhou Medical University,Yiwu,China
Scopus学科分类	Biochemistry;Molecular Biology;Genetics;Clinical Biochemistry;Cell Biology
引用统计	被引频次：22[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/3461
专题	药学院（分析测试中心）研究生工作部（研究生院）其他_附属义乌医院（义乌市中心医院）
通讯作者	Lou, Zhencai
作者单位	1.School of Pharmaceutical Sciences,Key Laboratory of Biotechnology and Pharmaceutical Engineering,Wenzhou Medical University,Wenzhou,China; 2.Wound Healing and Cell Biology Laboratory,Institute of Basic Medical Science,Chinese PLA General Hospital,Beijing,China; 3.Department of Otorhinolaryngology,The Affiliated YiWu Hospital,Wenzhou Medical University,Yiwu,China
第一作者单位	药学院（分析测试中心）
通讯作者单位	附属义乌医院（义乌市中心医院）
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Shi, Hongxue,Lin, Beibei,Huang, Yan,et al. Basic fibroblast growth factor promotes melanocyte migration via activating PI3K/Akt-Rac1-FAK-JNK and ERK signaling pathways[J]. IUBMB LIFE,2016,68(9):735-747.
APA	Shi, Hongxue., Lin, Beibei., Huang, Yan., Wu, Jiang., Zhang, Hongyu., ... & Xiao, Jian. (2016). Basic fibroblast growth factor promotes melanocyte migration via activating PI3K/Akt-Rac1-FAK-JNK and ERK signaling pathways. IUBMB LIFE, 68(9), 735-747.
MLA	Shi, Hongxue,et al."Basic fibroblast growth factor promotes melanocyte migration via activating PI3K/Akt-Rac1-FAK-JNK and ERK signaling pathways".IUBMB LIFE 68.9(2016):735-747.