STAT3 Promotes Invasion and Aerobic Glycolysis of Human Oral Squamous Cell Carcinoma via Inhibiting FoxO1

doi:10.3389/fonc.2019.01175

科研成果详情

题名	STAT3 Promotes Invasion and Aerobic Glycolysis of Human Oral Squamous Cell Carcinoma via Inhibiting FoxO1
作者	Zheng, Min1; Cao, Ming-xin 2,3; Yu, Xiang-hua 2,3; Li, Li 1; Wang, Ke 2,3; Wang, Sha-sha 2,3; Wang, Hao-fan 2,3; Tang, Ya-Jie 4; Tang, Ya-ling 2,5; Liang, Xin-hua 2,3
发表日期	2019-11-05
发表期刊	Frontiers in oncology 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Retracted Publication
关键词	EMT FoxO1 OSCC STAT3 aerobic glycolysis.
其他关键词	EPITHELIAL-MESENCHYMAL TRANSITION ; TUMOR PROGRESSION ; CANCER-CELLS ; NECK-CANCER ; HEAD ; TRANSCRIPTION ; METASTASIS ; PATHWAY ; PROLIFERATION ; METABOLISM
摘要	Signal transducer and activator of transcription 3 (STAT3), a previously accepted tumor-promoting protein in various malignancies, plays a key role in the process of cancer glycolysis. However, the role and potential mechanism of STAT3 in aerobic glycolysis and progression of oral squamous cell carcinoma (OSCC) has not been explored. In the present study, we demonstrated that STAT3 knockdown remarkably inhibited migration, invasion, expressions of epithelial-mesenchymal transition (EMT) markers, and aerobic glycolysis of OSCC cells by up-regulation of FoxO1. Consistently, the expression of nuclear Tyr705-phosphorylated STAT3, an active form of STAT3, was significantly elevated in OSCC tissues compared with adjacent normal tissues, and increased nuclear staining of Tyr705-phosphorylated STAT3 was associated with metastasis and shorter overall survival. Moreover, FoxO1, which was also mainly expressed in OSCC specimens, decreased in poorly-differentiated tissues compared with the relatively well-differentiated ones, and inversely correlated with the expression of nuclear Tyr705-phosphorylated STAT3 from patients with OSCC. Hence, our findings collectively characterized the contributing role of STAT3/FoxO1 in invasion and aerobic glycolysis of OSCC cells, which may lead to the worse clinical outcome.
资助项目	National Natural Science Foundation of China [81672672, 81572650, 81772891, 81502357, 81972542]; Natural Science Foundation of Zhejiang Province [Q142114001]; Zhoushan Science and Technology Bureau Project [2014C31068]; State Key Laboratory of Oral Diseases
出版者	FRONTIERS MEDIA SA
ISSN	2234-943X
卷号	9 页码:1175
DOI	10.3389/fonc.2019.01175
页数	11
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000498538400001
收录类别	PUBMED ; SCIE
URL	查看原文
Pubmed记录号	31750256
PMC记录号	PMC6848388
通讯作者地址	[Tang, Ya-ling;Liang, Xin-hua]Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu, Sichuan, Peoples R China. ; [Liang, Xin-hua]Sichuan Univ, West China Hosp Stomatol, Dept Oral & Maxillofacial Surg, Natl Clin Res Ctr Oral Dis, Chengdu, Sichuan, Peoples R China. ; [Tang, Ya-Jie]Shandong Univ, State Key Lab Microbial Technol, Qingdao, Shandong, Peoples R China. ; [Tang, Ya-ling]Sichuan Univ, West China Hosp Stomatol, Dept Oral Pathol, Natl Clin Res Ctr Oral Dis, Chengdu, Sichuan, Peoples R China.
引用统计	被引频次：21[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/34380
专题	其他_附属舟山医院（舟山医院）
通讯作者	Tang, Ya-Jie; Liang, Xin-hua
作者单位	1.Wenzhou Med Univ, Zhoushan Hosp, Dept Stomatol, Zhoushan, Peoples R China; 2.Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu, Sichuan, Peoples R China; 3.Sichuan Univ, West China Hosp Stomatol, Dept Oral & Maxillofacial Surg, Natl Clin Res Ctr Oral Dis, Chengdu, Sichuan, Peoples R China; 4.Shandong Univ, State Key Lab Microbial Technol, Qingdao, Shandong, Peoples R China; 5.Sichuan Univ, West China Hosp Stomatol, Dept Oral Pathol, Natl Clin Res Ctr Oral Dis, Chengdu, Sichuan, Peoples R China
第一作者单位	附属舟山医院（舟山医院）
第一作者的第一单位	附属舟山医院（舟山医院）
推荐引用方式 GB/T 7714	Zheng, Min,Cao, Ming-xin,Yu, Xiang-hua,et al. STAT3 Promotes Invasion and Aerobic Glycolysis of Human Oral Squamous Cell Carcinoma via Inhibiting FoxO1[J]. Frontiers in oncology,2019,9:1175.
APA	Zheng, Min., Cao, Ming-xin., Yu, Xiang-hua., Li, Li., Wang, Ke., ... & Liang, Xin-hua. (2019). STAT3 Promotes Invasion and Aerobic Glycolysis of Human Oral Squamous Cell Carcinoma via Inhibiting FoxO1. Frontiers in oncology, 9, 1175.
MLA	Zheng, Min,et al."STAT3 Promotes Invasion and Aerobic Glycolysis of Human Oral Squamous Cell Carcinoma via Inhibiting FoxO1".Frontiers in oncology 9(2019):1175.