The hemoglobin, albumin, lymphocyte, and platelet (HALP) score as a prognostic marker for patients with upper tract urothelial carcinoma undergoing radical nephroureterectomy: a retrospective study from two centers

doi:10.17305/bjbms.2021.6543

科研成果详情

题名	The hemoglobin, albumin, lymphocyte, and platelet (HALP) score as a prognostic marker for patients with upper tract urothelial carcinoma undergoing radical nephroureterectomy: a retrospective study from two centers
作者	Gao, Xiaomin 1; Lin, Binwei 2; Lin, Qi 1; Ye, Tingyu1; Zhou, Tao 1; Hu, Maolin 3; Zhu, Honghui1; Lu, Feng1; Chen, Wei 1; Xia, Peng4; Zhang, Fangyi1; Yu, Zhixian1
发表日期	2022
发表期刊	Bosnian journal of basic medical sciences 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Post-operative survival HALP upper tract urothelial carcinoma prognostic model
其他关键词	PROGNOSTIC-FACTOR ; PREOPERATIVE ANEMIA ; CANCER ; ALBUMIN ; LYMPHOCYTE ; PLATELET ; HEMOGLOBIN ; COMBINATION ; CYSTECTOMY ; INDICATOR
摘要	The combination of hemoglobin, albumin, lymphocyte, and platelet (HALP) score has been confirmed as an important risk biomarker in several cancers. Hence, we aimed at evaluating the prognostic value of the HALP score in patients with non-metastatic upper tract urothelial carcinoma (UTUC). We retrospectively enrolled 533 of the 640 patients from two centers (315 and 325 patients, respectively) who underwent radical nephroureterectomy (RNU) for UTUC in this study. The cutoff value of HALP was determined using the Youden index by performing receiver operating characteristic (ROC) curve analysis. The relationship between postoperative survival outcomes and preoperative HALP level was assessed using Kaplan-Meier analysis and Cox regression analysis. As a result, the cutoff value of HALP was 28.67 and patients were then divided into HALP<28.67 group and HALP≥28.67 group. Kaplan-Meier analysis and log-rank test revealed that HALP was significantly associated with overall survival (OS) (P<0.001) and progression-free survival (PFS) (P<0.001). Multivariate analysis demonstrated that lower HALP score was an independent risk factor for OS (HR=1.54, 95%CI, 1.14-2.01, P=0.006) and PFS (HR=1.44, 95%CI, 1.07-1.93, P=0.020). Nomograms of OS and PFS incorporated with HALP score were more accurate in predicting prognosis than without. In the subgroup analysis, the HALP score could also stratify patients with respect to survival under different pathologic T stages. Therefore, pretreatment HALP score was an independent prognostic factor of OS and PFS in UTUC patients undergoing RNU.
出版者	ASSOC BASIC MEDICAL SCI FEDERATION BOSNIA & HERZEGOVINA SARAJEVO
出版地	CEKALUSA
ISSN	1512-8601
EISSN	1840-4812
卷号	22 期号:2 页码:280-290
DOI	10.17305/bjbms.2021.6543
页数	11
WOS类目	Medicine, Research & Experimental
WOS研究方向	Research & Experimental Medicine
WOS记录号	WOS:000819849100014
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	35020581
SCOPUSEID	2-s2.0-85128161019
通讯作者地址	[Xia, Peng]Department of Transplantation,The First Affiliated Hospital of Wenzhou Medical University,Southern Baixiang,OuHai District, Zhejiang province,Wenzhou,China ; [Zhang, Fangyi]The First Affiliated Hospital of Wenzhou Medical University,Southern Baixiang,OuHai District, Zhejiang province, 325006,Wenzhou,China ; [Yu, Zhixian]Department of Urology,The First Affiliated Hospital of Wenzhou Medical University,southern Baixiang,OuHai District, Zhejiang province,Wenzhou,China
Scopus学科分类	Medicine (all)
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/34142
专题	附属第一医院_泌尿外科附属第一医院_移植科其他_附属第三医院（瑞安市人民医院）
通讯作者	Xia, Peng; Zhang, Fangyi; Yu, Zhixian
作者单位	1.Department of Urology,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.Department of Urology,Rui’an People’s Hospital,The Third Affiliated Hospital of the Wenzhou Medical University,Zhejiang,Wenzhou,China; 3.Department of Urology,Second Affiliated Hospital,Zhejiang University School of Medicine,Zhejiang,Hangzhou,China; 4.Department of Transplantation,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Gao, Xiaomin,Lin, Binwei,Lin, Qi,et al. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score as a prognostic marker for patients with upper tract urothelial carcinoma undergoing radical nephroureterectomy: a retrospective study from two centers[J]. Bosnian journal of basic medical sciences,2022,22(2):280-290.
APA	Gao, Xiaomin., Lin, Binwei., Lin, Qi., Ye, Tingyu., Zhou, Tao., ... & Yu, Zhixian. (2022). The hemoglobin, albumin, lymphocyte, and platelet (HALP) score as a prognostic marker for patients with upper tract urothelial carcinoma undergoing radical nephroureterectomy: a retrospective study from two centers. Bosnian journal of basic medical sciences, 22(2), 280-290.
MLA	Gao, Xiaomin,et al."The hemoglobin, albumin, lymphocyte, and platelet (HALP) score as a prognostic marker for patients with upper tract urothelial carcinoma undergoing radical nephroureterectomy: a retrospective study from two centers".Bosnian journal of basic medical sciences 22.2(2022):280-290.