Identification and Validation of Hub Genes Predicting Prognosis of Hepatocellular Carcinoma

doi:10.1159/000520893

科研成果详情

题名	Identification and Validation of Hub Genes Predicting Prognosis of Hepatocellular Carcinoma
作者	Chen, Ziyan 1,2; Yu, Haitao 1,2; Wu, Lijun 1,2; Zhang, Sina 1; Lin, Zhihui1; Deng, Tuo 1,2; He, Bangjie 1,2; Yu, Zhengping1,2; Chen, Gang1,2; Wu, Fang 1
发表日期	2022-03
发表期刊	Digestive surgery 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Cox regression model Hepatocellular carcinoma Hub gene Prognosis.
其他关键词	ZIPPER KINASE MELK ; EXPRESSION ; OUTCOMES
摘要	Introduction:The aim of this study is selecting the hub genes associated with hepatocellular carcinoma (HCC) to construct a Cox regression model for predicting prognosis in HCC patients. Methods:Using HCC patient data from the ICGC and TCGA databases, screened for 40 core genes highly correlated with histological grade of HCC. Univariate and multivariate Cox regression analyses were performed on the genes highly associated with HCC prognosis, and the model was established. The expression of those genes was measured by immunohistochemistry in 110 HCC patients who underwent the surgery in the First Affiliated Hospital of Wenzhou Medical University. The survival of HCC patients was analyzed by the Kaplan-Meier method. Results:Eight genes (CDC45, CENPA, MCM10, MELK, CDC20, ASF1B, FANCD2, and NCAPH) were correlated with prognosis, and the same result was observed in 110 HCC patients. Using the regression model, the HCC patients in the training set were classified as high- and low-risk groups. The overall survival of patients in the high-risk group was shorter than that in the low-risk group, and the same results were obtained in the verification set. Conclusion:This study found that the risk model according to these 8 genes can be used as a predictor of prognosis in HCC. These genes may become alternative biomarkers and therapeutic targets and provide new therapeutic strategies for HCC.
资助项目	National Natural Science Foundation of China [81772628, 82072685, 81703310]; National Medical and Health Technology Project for Zhejiang Province [WKJ-ZJ-1706]
出版者	KARGER
出版地	BASEL
ISSN	0253-4886
EISSN	1421-9883
卷号	39 期号:1 页码:24-31.
DOI	10.1159/000520893
页数	8
WOS类目	Gastroenterology & Hepatology ; Surgery
WOS研究方向	Gastroenterology & Hepatology ; Surgery
WOS记录号	WOS:000784340600004
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	34788753
SCOPUSEID	2-s2.0-85126830268
通讯作者地址	[Wu, Fang]Department of Hepatobiliary Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Surgery;Gastroenterology
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/33887
专题	附属第一医院_肝胆外科第一临床医学院（信息与工程学院）、附属第一医院_浙江省胰脏肝脏危重性疾病重点实验室
通讯作者	Wu, Fang
作者单位	1.Department of Hepatobiliary Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chen, Ziyan,Yu, Haitao,Wu, Lijun,et al. Identification and Validation of Hub Genes Predicting Prognosis of Hepatocellular Carcinoma[J]. Digestive surgery,2022,39(1):24-31..
APA	Chen, Ziyan., Yu, Haitao., Wu, Lijun., Zhang, Sina., Lin, Zhihui., ... & Wu, Fang. (2022). Identification and Validation of Hub Genes Predicting Prognosis of Hepatocellular Carcinoma. Digestive surgery, 39(1), 24-31..
MLA	Chen, Ziyan,et al."Identification and Validation of Hub Genes Predicting Prognosis of Hepatocellular Carcinoma".Digestive surgery 39.1(2022):24-31..