Maltol Promotes Mitophagy and Inhibits Oxidative Stress via the Nrf2/PINK1/Parkin Pathway after Spinal Cord Injury

doi:10.1155/2022/1337630

科研成果详情

题名	Maltol Promotes Mitophagy and Inhibits Oxidative Stress via the Nrf2/PINK1/Parkin Pathway after Spinal Cord Injury
作者	Mao, Yuqin; Du, Jiqing; Chen, Xianghang; Al Mamun, Abdullah; Cao, Lin; Yang, Yanhong; Mubwandarikwa, Joana; Zaeem, Muhammad; Zhang, Wanying; Chen, Yan; Dai, Yusen; Xiao, Jian; Ye, Keyong
发表日期	2022-02-01
发表期刊	Oxidative medicine and cellular longevity 影响因子和分区
语种	英语
原始文献类型	Journal article (JA)
关键词	Cell death Molecular biology 'current Antioxidative property Central nervous systems Cytosols Fatal disease Neuronal cell Neuronal regenerations Retranslocation Spinal cord injury Stress signals
其他关键词	MITOCHONDRIAL ; PINK1 ; NRF2
摘要	Spinal cord injury (SCI), a fatal disease in the central nervous system, is characteristic of weak neuronal regeneration ability and complex pathological progress. Activation of oxidative stress (OS) and apoptosis-mediated cell death significantly contributes to the progression of SCI. Current evidence suggests that maltol exerts natural antioxidative properties via obstructing OS and apoptosis. However, the significant effect of maltol on SCI treatment has never been evaluated yet. In our current study, we explored maltol administration that could trigger the expression of Nrf2 and promote the retranslocation of Nrf2 from the cytosol to the nucleus, which can subsequently obstruct OS signal and apoptosis-mediated neuronal cell death after SCI. Furthermore, we found that maltol treatment enhances PINK1/Parkin-mediated mitophagy in PC12 cells, facilitating the recovery of mitochondrial functions. Our findings propose that maltol could be a promising therapeutic candidate for the treatment and management of SCI.
资助项目	National Natural Science Foundation of China [81972150, 82172428]; Zhejiang Provincial Natural Science Foundation [LR18H150001, LQ18H090008]
出版者	Hindawi Limited
出版地	LONDON
ISSN	1942-0994
EISSN	1942-0994
卷号	2022 页码:1337630
DOI	10.1155/2022/1337630
页数	43
WOS类目	Cell Biology
WOS研究方向	Cell Biology
WOS记录号	WOS:000769453100001
收录类别	PUBMED ; EI ; SCOPUS ; SCIE
EI入藏号	20220811694948
EI主题词	Patient rehabilitation
EI分类号	461.5 Rehabilitation Engineering and Assistive Technology ; 461.9 Biology
URL	查看原文
PubMed ID	35154562
PMC记录号	PMC8826207
SCOPUSEID	2-s2.0-85124618326
通讯作者地址	[Du, Jiqing]Department of Orthopaedics,Affiliated Pingyang Hospital and School of Pharmaceutical Science,Wenzhou Medical University,Wenzhou,Zhejiang,325000,China ; [Xiao, Jian]Department of Orthopaedics,Affiliated Pingyang Hospital and School of Pharmaceutical Science,Wenzhou Medical University,Wenzhou,Zhejiang,325000,China ; [Ye, Keyong]Department of Orthopaedics,Affiliated Pingyang Hospital and School of Pharmaceutical Science,Wenzhou Medical University,Wenzhou,Zhejiang,325000,China
Scopus学科分类	Biochemistry;Aging;Cell Biology
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/33853
专题	药学院（分析测试中心）研究生工作部（研究生院）其他_附属平阳医院（平阳县人民医院）
通讯作者	Du, Jiqing; Xiao, Jian; Ye, Keyong
作者单位	Department of Orthopaedics,Affiliated Pingyang Hospital and School of Pharmaceutical Science,Wenzhou Medical University,Zhejiang,325000,China
第一作者单位	附属平阳医院（平阳县人民医院）
通讯作者单位	附属平阳医院（平阳县人民医院）
第一作者的第一单位	附属平阳医院（平阳县人民医院）
推荐引用方式 GB/T 7714	Mao, Yuqin,Du, Jiqing,Chen, Xianghang,et al. Maltol Promotes Mitophagy and Inhibits Oxidative Stress via the Nrf2/PINK1/Parkin Pathway after Spinal Cord Injury[J]. Oxidative medicine and cellular longevity,2022,2022:1337630.
APA	Mao, Yuqin., Du, Jiqing., Chen, Xianghang., Al Mamun, Abdullah., Cao, Lin., ... & Ye, Keyong. (2022). Maltol Promotes Mitophagy and Inhibits Oxidative Stress via the Nrf2/PINK1/Parkin Pathway after Spinal Cord Injury. Oxidative medicine and cellular longevity, 2022, 1337630.
MLA	Mao, Yuqin,et al."Maltol Promotes Mitophagy and Inhibits Oxidative Stress via the Nrf2/PINK1/Parkin Pathway after Spinal Cord Injury".Oxidative medicine and cellular longevity 2022(2022):1337630.