Limonin Inhibits IL-1 β-Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2

doi:10.1155/2021/7292512

科研成果详情

题名	Limonin Inhibits IL-1 β-Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2
作者	Jin, Jie 1,2,3; Lv, Xinhuang4; Wang, Ben1,2,3; Ren, Chenghao 1,2,3; Jiang, Jingtao 1,2,3; Chen, Hongyu1,2,3; Chen, Ximiao1,2,3; Gu, Mingbao 1,2,3; Pan, Zongyou 5; Tian, Naifeng1,2,3; Wu, Aimin 1,2,3; Sun, Liaojun1,2,3; Gao, Weiyang1,2,3; Wang, Xiangyang1,2,3; Zhang, Xiaolei 1,2,3,6; Wu, Yaosen1,2,3; Zhou, Yifei1,2,3
发表日期	2021-11-09
发表期刊	Oxidative medicine and cellular longevity 影响因子和分区
语种	英语
原始文献类型	Journal article (JA)
关键词	Biochemistry Mammals Pathology Anti-inflammatory effects Chondrocytes IL-1β In-vitro In-vivo Limonin Proinflammatory cytokines Signalling pathways Therapeutic effects Working mechanisms
其他关键词	NF-KAPPA-B ; NITRIC-OXIDE ; PATHWAY ; PATHOGENESIS ; EXPRESSION ; LIMONOIDS ; BURDEN ; RISK
摘要	Osteoarthritis (OA), a degenerative disorder, is considered to be one of the most common forms of arthritis. Limonin (Lim) is extracted from lemons and other citrus fruits. Limonin has been reported to have anti-inflammatory effects, while inflammation is a major cause of OA; thus, we propose that limonin may have a therapeutic effect on OA. In this study, the therapeutic effect of limonin on OA was assessed in chondrocytes in vitro in IL-1β induced OA and in the destabilization of the medial meniscus (DMM) mice in vivo. The Nrf2/HO-1/NF-κB signaling pathway was evaluated to illustrate the working mechanism of limonin on OA in chondrocytes. In this study, it was found that limonin can reduce the level of IL-1β induced proinflammatory cytokines such as INOS, COX-2, PGE2, NO, TNF-α, and IL-6. Limonin can also diminish the biosynthesis of IL-1β-stimulated chondrogenic catabolic enzymes such as MMP13 and ADAMTS5 in chondrocytes. The research on the mechanism study demonstrated that limonin exerts its protective effect on OA through the Nrf2/HO-1/NF-κB signaling pathway. Taken together, the present study shows that limonin may activate the Nrf2/HO-1/NF-κB pathway to alleviate OA, making it a candidate therapeutic agent for OA.
资助项目	National Natural Science Foundation of China [81902243]; Zhejiang Provincial Natural Science Foundation of China [LQ19H060004]; Wenzhou Science and Technology Bureau Foundation [ZY2019014]; Lin He's New Medicine and Clinical Translation Academician Workstation Research Fund [18331213]
出版者	Hindawi Limited
ISSN	1942-0994
EISSN	1942-0994
卷号	2021 页码:7292512
DOI	10.1155/2021/7292512
页数	46
WOS类目	Cell Biology
WOS研究方向	Cell Biology
WOS记录号	WOS:000820146000002
收录类别	PUBMED ; EI ; SCOPUS ; SCIE
EI入藏号	20214811241356
EI主题词	Citrus fruits
URL	查看原文
PubMed ID	34795843
PMC记录号	PMC8595032
SCOPUSEID	2-s2.0-85119981598
通讯作者地址	[Zhang, Xiaolei]Department of Orthopaedics,Second Affiliated Hospital and Yuying Children's Hospital,Wenzhou Medical University,Zhejiang Province,Wenzhou,China ; [Wu, Yaosen]Department of Orthopaedics,Second Affiliated Hospital and Yuying Children's Hospital,Wenzhou Medical University,Zhejiang Province,Wenzhou,China ; [Zhou, Yifei]Department of Orthopaedics,Second Affiliated Hospital and Yuying Children's Hospital,Wenzhou Medical University,Zhejiang Province,Wenzhou,China
Scopus学科分类	Biochemistry;Aging;Cell Biology
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/33846
专题	第二临床医学院、附属第二医院、育英儿童医院附属第二医院附属第一医院药学院（分析测试中心）_实验神经生物研究所
通讯作者	Zhang, Xiaolei; Wu, Yaosen; Zhou, Yifei
作者单位	1.Department of Orthopaedics,Second Affiliated Hospital and Yuying Children's Hospital,Wenzhou Medical University,Zhejiang Province,Wenzhou,China; 2.Zhejiang Provincial Key Laboratory of Orthopedics,Zhejiang Province,Wenzhou,China; 3.Second School of Medicine,Wenzhou Medical University,Zhejiang Province,Wenzhou,China; 4.Research Institute of Experimental Neurobiology,Department of Neurology,First Affiliated Hospital,Wenzhou Medical University,Zhejiang Province,Wenzhou,China; 5.Chinese Orthopaedic Regenerative Medicine Society,Zhejiang Province,Hangzhou,China; 6.Department of Orthopaedics,Second Affiliated Hospital of Zhejiang University,School of Medicine,Zhejiang Province,Hangzhou,China
第一作者单位	附属第二医院; 温州医科大学
通讯作者单位	附属第二医院
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Jin, Jie,Lv, Xinhuang,Wang, Ben,et al. Limonin Inhibits IL-1 β-Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2[J]. Oxidative medicine and cellular longevity,2021,2021:7292512.
APA	Jin, Jie., Lv, Xinhuang., Wang, Ben., Ren, Chenghao., Jiang, Jingtao., ... & Zhou, Yifei. (2021). Limonin Inhibits IL-1 β-Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2. Oxidative medicine and cellular longevity, 2021, 7292512.
MLA	Jin, Jie,et al."Limonin Inhibits IL-1 β-Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2".Oxidative medicine and cellular longevity 2021(2021):7292512.