Upregulation of oxidative stress-responsive 1(OXSR1) predicts poor prognosis and promotes hepatocellular carcinoma progression

doi:10.1080/21655979.2020.1814659

科研成果详情

题名	Upregulation of oxidative stress-responsive 1(OXSR1) predicts poor prognosis and promotes hepatocellular carcinoma progression
作者	Chen, Jianhui 1,2; Zhou, Jiangfan3; Fu, Haotian 2; Ni, Xiaofeng1,2; Shan, Yunfeng2
发表日期	2020
发表期刊	Bioengineered 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Research Support, Non-U.S. Gov't ; Retracted Publication
关键词	Oxidative stress-responsive 1 hepatocellular carcinoma immune infiltration p53-R249S.
其他关键词	EPITHELIAL-MESENCHYMAL TRANSITION ; TUMOR-INFILTRATING LYMPHOCYTES ; KINASES ; OSR1 ; CANCER ; SPAK ; P53 ; METASTASIS ; ACTIVATION ; EXPRESSION
摘要	Many studies reported that Oxidative stress-responsive 1(OXSR1) is closely related to the malignant progression of several malignancies. Nevertheless, the expression pattern and function of OXSR1 in HCC remains unknown. In present research, it was observed that the expression of OXSR1 was abnormally elevated in HCC. Upregulated OXSR1 was associated with TNM stage, and grade and was confirmed as an independent prognostic factor in HCC patients. The downregulation of OXSR1 expression effectively repressed the proliferation, migration and invasion of HCC in vivo and in vitro experiments. Western blot and qRT-PCR analysis demonstrated that mutant p53-R249S was critical for regulating the aberrant elevation of OXSR1 in HCC. Chip assay indicated that p53-R249S abrogated the binding of p53 to the OXSR1 promoter region and increased the level of POL2, H3Kac and H4Kac in the promoter region of the OXSR1, thus promoting the transcriptional expression of OXSR1. GSEA revealed that numerous cancer-related pathways were enriched in the high OXSR1 expression group. Furthermore, the expression level of OXSR1 was positively correlated with the infiltration levels of tumor infiltrating immune cells (TIICs) and PD-L1 expression in HCC by TIMER platform. In summary, our study revealed that upregulated OXSR1 was a determinant of prognosis and immune infiltration in HCC. The expression of OXSR1 was released by p53-R249S mutant, and upregulated OXSR1 in HCC promoted proliferation, migration and invasion.
资助项目	National Natural Science Foundation of China [81700568]
出版者	TAYLOR & FRANCIS INC
ISSN	2165-5979
EISSN	2165-5987
卷号	11 期号:1 页码:958-971.
DOI	10.1080/21655979.2020.1814659
页数	14
WOS类目	Biotechnology & Applied Microbiology
WOS研究方向	Biotechnology & Applied Microbiology
WOS记录号	WOS:000565793500001
收录类别	PUBMED ; SCIE
URL	查看原文
Pubmed记录号	32842855
PMC记录号	PMC8291867
通讯作者地址	[Shan, Yunfeng]Wenyi First Hosp, New Hosp Dist, Wenzhou, Zhejiang, Peoples R China.
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/33618
专题	第一临床医学院（信息与工程学院）、附属第一医院_浙江省胰脏肝脏危重性疾病重点实验室附属第一医院_肝胆外科附属第一医院_介入科
通讯作者	Shan, Yunfeng
作者单位	1.Wenzhou Med Univ, Key Lab Diag & Treatment Severe Hepatopancreat Di, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Dept Intervent, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China
第一作者单位	附属第一医院; 肝胆外科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chen, Jianhui,Zhou, Jiangfan,Fu, Haotian,et al. Upregulation of oxidative stress-responsive 1(OXSR1) predicts poor prognosis and promotes hepatocellular carcinoma progression[J]. Bioengineered,2020,11(1):958-971..
APA	Chen, Jianhui, Zhou, Jiangfan, Fu, Haotian, Ni, Xiaofeng, & Shan, Yunfeng. (2020). Upregulation of oxidative stress-responsive 1(OXSR1) predicts poor prognosis and promotes hepatocellular carcinoma progression. Bioengineered, 11(1), 958-971..
MLA	Chen, Jianhui,et al."Upregulation of oxidative stress-responsive 1(OXSR1) predicts poor prognosis and promotes hepatocellular carcinoma progression".Bioengineered 11.1(2020):958-971..