Incidence and risk factors for venous thromboembolism during an acute attack in patients with neuromyelitis optica spectrum disorders

doi:10.1016/j.msard.2022.103513

科研成果详情

题名	Incidence and risk factors for venous thromboembolism during an acute attack in patients with neuromyelitis optica spectrum disorders
作者	Pan, Juyuan; Zhu, Ruofan; Lin, Jie; Li, Xiang; Xia, Junhui
发表日期	2022-02
发表期刊	Multiple sclerosis and related disorders 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Incidence Neuromyelitis optica spectrum disorders Risk factor Venous thromboembolism.
其他关键词	MULTIPLE-SCLEROSIS ; INFLAMMATION ; DISABILITY ; PREVALENCE
摘要	Background:Neuromyelitis optica spectrum disorders (NMOSD) patients may be at increased risk of venous thromboembolism (VTE) during the acute attack, but evidence is limited. Objective:To investigate the incidence of venous thromboembolism (VTE) in Neuromyelitis optica spectrum disorders (NMOSD) patients with an acute attack and to identify the potential risk factors for the development of VTE. Methods:We conducted a retrospective study of NMOSD patients with an acute attack between January 1, 2015, and June 31, 2021. Diagnosis of DVT or PE was objectively confirmed by doppler ultrasound or computed tomographic pulmonary angiography (CTPA) during their acute hospital stay. Results:We identified 184 attacks in 128 NMOSD patients with the mean age of 46.9 years at the time of the attack and female predominance (152/184, 83.2%). VTE occurred in 22 (12.0%) attacks. Among the 22 attacks, 20 presented with transverse myelitis (TM), 1 cerebral syndrome (CS), and 1 simultaneous TM and brainstem syndrome (BS). Multivariable logistic regression analysis showed that advanced age [odds ratio (OR) = 1.08, 95% confidence interval (CI) = 1.04-1.12, p = 0.000], Nadir Expanded Disability Status Scale (EDSS)>6.5(OR = 3.39, 95% CI = 1.22-10.10, p = 0.029) and intravenous immunoglobulin (IVIG) treatment (OR = 3.21, 95% CI = 1.15-8.91, p = 0.025) were independent risk factors for the development of VTE in the total NMOSD cohort. In the subgroup analysis of the NMOSD patients with TM, age at attack (OR = 1.07, 95% CI = 1.03-1.11, p = 0.002) and IVIG treatment (OR = 4.23, 95% CI = 1.44-12.45, p = 0.009) were independent risk factors for the development of VTE in the total NMOSD cohort, but Nadir EDSS>6.5 was not an independent risk factor. Conclusions:VTE is a frequent complication in NMOSD patients, especially in patients with TM. Advanced age and IVIG are independent risk factors for VTE. Immobilization is an independent risk factor for VTE in the total NMOSD cohort but not in the subgroup analysis of the patients with TM.
资助项目	Wenzhou Municipal Science and Technology Bureau [Y20170066, Y20210168]
出版者	ELSEVIER SCI LTD
出版地	OXFORD
ISSN	2211-0348
EISSN	2211-0356
卷号	58 页码:103513
DOI	10.1016/j.msard.2022.103513
页数	5
WOS类目	Clinical Neurology
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000791999800012
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	35038646
SCOPUSEID	2-s2.0-85123245491
通讯作者地址	[Xia, Junhui]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Neurology;Neurology (clinical)
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/33445
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
通讯作者	Xia, Junhui
作者单位	Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
通讯作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
推荐引用方式 GB/T 7714	Pan, Juyuan,Zhu, Ruofan,Lin, Jie,et al. Incidence and risk factors for venous thromboembolism during an acute attack in patients with neuromyelitis optica spectrum disorders[J]. Multiple sclerosis and related disorders,2022,58:103513.
APA	Pan, Juyuan, Zhu, Ruofan, Lin, Jie, Li, Xiang, & Xia, Junhui. (2022). Incidence and risk factors for venous thromboembolism during an acute attack in patients with neuromyelitis optica spectrum disorders. Multiple sclerosis and related disorders, 58, 103513.
MLA	Pan, Juyuan,et al."Incidence and risk factors for venous thromboembolism during an acute attack in patients with neuromyelitis optica spectrum disorders".Multiple sclerosis and related disorders 58(2022):103513.