KGF-2 Regulates STAP-2-Mediated Signal Transducer and Activator of Transcription 3 Signaling and Reduces Skin Scar Formation

doi:10.1016/j.jid.2021.12.018

科研成果详情

题名	KGF-2 Regulates STAP-2-Mediated Signal Transducer and Activator of Transcription 3 Signaling and Reduces Skin Scar Formation
作者	Zhou, Qingde 1,2,3; Gong, Jianxiang 2,3; Bi, Jianing2,3; Yang, Xuanxin2,3; Zhang, Li 1; Lu, Chao 2,3; Li, Lijia 2,3; Chen, Min 2,3; Cai, Jianqiu2; Yang, Rongshuai 2; Li, Xiaokun2,3,4; Li, Zhiming1; Wang, Xiaojie 1,2,3,4
发表日期	2022-07
发表期刊	The Journal of investigative dermatology 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	KERATINOCYTE GROWTH FACTOR-2 ; EXPRESSION ; CLONING ; MODEL ; FGF10
摘要	Hypertrophic scar is a common complication of burns, skin trauma, and postoperative trauma, which involves excessive proliferation of fibroblasts and accumulation of a large amount of disorganized collagen fibers and extracellular matrix. KGF-2 plays important roles in the regulation of cellular homeostasis and wound healing. In this study, we investigated the effect and underlying mechanism of KGF-2 on scar formation after wound healing both in vitro and in vivo. We show that KGF-2 attenuates mechanical stress-induced scar formation while promoting wound healing. Mechanistically, KGF-2 inhibits STAP-2 expression and signal transducer and activator of transcription 3 activation, leading to significantly reduced collagen I and collagen III levels. Our results provide an insight into the role of KGF-2 in wound healing and scar formation and the therapeutic potential for reducing scarring while promoting wound healing.
资助项目	National Natural Science Foundation of China[2016ZX09101117];
出版者	ELSEVIER SCIENCE INC
出版地	NEW YORK
ISSN	0022-202X
EISSN	1523-1747
卷号	142 期号:7 页码:2003-+
DOI	10.1016/j.jid.2021.12.018
页数	16
WOS类目	Dermatology
WOS研究方向	Dermatology
WOS记录号	WOS:000814391200005
收录类别	PUBMED ; SCOPUS ; SCIE
URL	查看原文
Pubmed记录号	34999107
Scopus记录号	2-s2.0-85125660197
自科自定义期刊分类	T3(B)类
通讯作者地址	[Wang, Xiaojie]Department of Dermatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
scopus学科分类	Biochemistry;Molecular Biology;Dermatology;Cell Biology
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/33410
专题	附属第一医院_皮肤科药学院（分析测试中心）
通讯作者	Wang, Xiaojie
作者单位	1.Department of Dermatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,China; 3.Laboratory of Zhejiang Province for Pharmaceutical Engineering and Development of Growth Factors,Collaborative Biomedical Innovation Center of Wenzhou,Wenzhou,China; 4.Research Units of Clinical Translation of Cell Growth Factors and Diseases,Chinese Academy of Medical Science,Beijing,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 药学院（分析测试中心）
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhou, Qingde,Gong, Jianxiang,Bi, Jianing,et al. KGF-2 Regulates STAP-2-Mediated Signal Transducer and Activator of Transcription 3 Signaling and Reduces Skin Scar Formation[J]. The Journal of investigative dermatology,2022,142(7):2003-+.
APA	Zhou, Qingde., Gong, Jianxiang., Bi, Jianing., Yang, Xuanxin., Zhang, Li., ... & Wang, Xiaojie. (2022). KGF-2 Regulates STAP-2-Mediated Signal Transducer and Activator of Transcription 3 Signaling and Reduces Skin Scar Formation. The Journal of investigative dermatology, 142(7), 2003-+.
MLA	Zhou, Qingde,et al."KGF-2 Regulates STAP-2-Mediated Signal Transducer and Activator of Transcription 3 Signaling and Reduces Skin Scar Formation".The Journal of investigative dermatology 142.7(2022):2003-+.