Schisandrin B suppresses gastric cancer cell growth and enhances the efficacy of chemotherapy drug 5-FU in vitro and in vivo

doi:10.1016/j.ejphar.2022.174823

科研成果详情

题名	Schisandrin B suppresses gastric cancer cell growth and enhances the efficacy of chemotherapy drug 5-FU in vitro and in vivo
作者	He, Leye 1; Chen, Hao1; Qi, Qinqin2; Wu, Nan 1; Wang, Ying 1; Chen, Mengxia1; Feng, Qian 1; Dong, Buyuan 1; Jin, Rong1; Jiang, Lei2
发表日期	2022-04-05
发表期刊	European journal of pharmacology 影响因子和分区
语种	英语
原始文献类型	Article
关键词	5-FU Autophagy Gastric cancer STAT3 Schisandrin B.
其他关键词	APOPTOSIS ; COMBINATION ; MORTALITY
摘要	Gastric cancer (GC) is a serious affliction worldwide and remains to be the fourth most common cancer with poor prognosis, especially in advanced stage. Chemotherapy is one of the main therapeutic means. The purpose of this study was to investigate the antitumor effects of Schisandrin B (Sch B) on GC cells both in vitro and in vivo, as well as the synergistic effect with 5-fluorouracil (5-FU), and to preliminarily explore the relevant mechanism of action. Our results showed that Sch B inhibited the growth, migration and invasion of GC cells. Besides, Sch B could effectively inhibit the phosphorylation of STAT3 (signal transducer and activator of transcription 3), induce autophagy, and enhance the efficacy of chemotherapy drug 5-FU in vitro and in vivo. Taken together, the findings indicate that Sch B displays potent antitumor activities. The co-administration of Sch B and 5-FU might be a promising way for future therapy of GC.
资助项目	Zhejiang Provincial Natural Science Foundation, China [LY19H160025]; Medicine and Health Technol-ogy Program of Zhejiang Province, China [2020KY635]; Wenzhou Science & technological Project, China [Y20170180]
出版者	ELSEVIER
出版地	AMSTERDAM
ISSN	0014-2999
EISSN	1879-0712
卷号	920 页码:174823
DOI	10.1016/j.ejphar.2022.174823
页数	10
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000783278200005
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	35157912
SCOPUSEID	2-s2.0-85125113420
通讯作者地址	[Jiang, Lei]Central Laboratory,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China ; [Jin, Rong]Department of Epidemiology,Department of Gastroenterology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Pharmacology
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/33319
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_中心实验室
通讯作者	Jin, Rong; Jiang, Lei
作者单位	1.Department of Gastroenterology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Central Laboratory,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	He, Leye,Chen, Hao,Qi, Qinqin,et al. Schisandrin B suppresses gastric cancer cell growth and enhances the efficacy of chemotherapy drug 5-FU in vitro and in vivo[J]. European journal of pharmacology,2022,920:174823.
APA	He, Leye., Chen, Hao., Qi, Qinqin., Wu, Nan., Wang, Ying., ... & Jiang, Lei. (2022). Schisandrin B suppresses gastric cancer cell growth and enhances the efficacy of chemotherapy drug 5-FU in vitro and in vivo. European journal of pharmacology, 920, 174823.
MLA	He, Leye,et al."Schisandrin B suppresses gastric cancer cell growth and enhances the efficacy of chemotherapy drug 5-FU in vitro and in vivo".European journal of pharmacology 920(2022):174823.