Predictive value of serum visinin-like protein-1 for early neurologic deterioration and three-month clinical outcome in acute primary basal ganglia hemorrhage: a prospective and observational study

doi:10.1016/j.cca.2022.03.008

科研成果详情

题名	Predictive value of serum visinin-like protein-1 for early neurologic deterioration and three-month clinical outcome in acute primary basal ganglia hemorrhage: a prospective and observational study
作者	Yan, Xin-Jiang1; Li, Yang-Bo1; Liu, Wei 1; Dai, Wei-Min 1; Wang, Chuan-Liu 2
发表日期	2022-06-01
发表期刊	Clinica chimica acta; international journal of clinical chemistry 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Intracerebral hemorrhage Outcome Severity Visinin-like protein 1.
其他关键词	CALCIUM SENSOR PROTEINS ; INTRACEREBRAL HEMORRHAGE ; VILIP-1 ; LOCALIZATION
摘要	Background:Visinin-like protein 1 (VILIP-1) appears as a biomarker of neuronal injury. We investigated the correlation of serum VILIP-1 concentrations with severity, early neurologic deterioration (END) and functional outcome of intracerebral hemorrhage (ICH). Methods:In this prospective and observational study, serum VILIP-1 concentrations were quantified in 106 patients with basal ganglia hemorrhage. Univariate and multivariable logistic regression analyses were used to analyze the relationship between serum VILIP-1 concentrations and END plus worse prognosis (modified Rankin Scale score of 3 or greater) at post-injury 3 months. Results:Serum VILIP-1 concentrations of patients were closely correlated with hematoma volume and National Institutes of Health Stroke Scale score. Serum VILIP-1 concentrations were substantially elevated in patients with END or worse 3-month prognosis, as compared to other remainders. Also, serum VILIP-1 concentrations were independently associated with END and worse 3-month prognosis. Under ROC curve analysis, serum VILIP-1 concentrations exhibited marked accuracy for distinguishing patients with the development of END or worse 3-month prognosis. Its predictive ability was in the range of hematoma volume and National Institutes of Health Stroke Scale score. Conclusions:Serum VILIP-1 may be a good biomarker for assessing hemorrhagic severity and clinical outcomes after ICH.
出版者	ELSEVIER
出版地	AMSTERDAM
ISSN	0009-8981
EISSN	1873-3492
卷号	531 页码:62-67
DOI	10.1016/j.cca.2022.03.008
页数	6
WOS类目	Medical Laboratory Technology
WOS研究方向	Medical Laboratory Technology
WOS记录号	WOS:000791233300009
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	35292254
SCOPUSEID	2-s2.0-85127013244
通讯作者地址	[Dai, Wei-Min]Department of Neurosurgery,The Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People's Hospital,100 Minjiang Road, Zhejiang Province,Quzhou,324000,China
Scopus学科分类	Biochemistry;Clinical Biochemistry;Biochemistry (medical)
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/33277
专题	其他_温州医科大学附属衢州医院
通讯作者	Dai, Wei-Min
作者单位	1.Department of Neurosurgery,The Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People's Hospital,100 Minjiang Road, Zhejiang Province,Quzhou,324000,China; 2.Department of Neurology,The Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People's Hospital,100 Minjiang Road, Zhejiang Province,Quzhou,324000,China
第一作者单位	其他_温州医科大学附属衢州医院
通讯作者单位	其他_温州医科大学附属衢州医院
第一作者的第一单位	其他_温州医科大学附属衢州医院
推荐引用方式 GB/T 7714	Yan, Xin-Jiang,Li, Yang-Bo,Liu, Wei,et al. Predictive value of serum visinin-like protein-1 for early neurologic deterioration and three-month clinical outcome in acute primary basal ganglia hemorrhage: a prospective and observational study[J]. Clinica chimica acta; international journal of clinical chemistry,2022,531:62-67.
APA	Yan, Xin-Jiang, Li, Yang-Bo, Liu, Wei, Dai, Wei-Min, & Wang, Chuan-Liu. (2022). Predictive value of serum visinin-like protein-1 for early neurologic deterioration and three-month clinical outcome in acute primary basal ganglia hemorrhage: a prospective and observational study. Clinica chimica acta; international journal of clinical chemistry, 531, 62-67.
MLA	Yan, Xin-Jiang,et al."Predictive value of serum visinin-like protein-1 for early neurologic deterioration and three-month clinical outcome in acute primary basal ganglia hemorrhage: a prospective and observational study".Clinica chimica acta; international journal of clinical chemistry 531(2022):62-67.