Targeting Gut Microbiota and Host Metabolism with Dendrobium officinale Dietary Fiber to Prevent Obesity and Improve Glucose Homeostasis in Diet-Induced Obese Mice

doi:10.1002/mnfr.202100772

科研成果详情

题名	Targeting Gut Microbiota and Host Metabolism with Dendrobium officinale Dietary Fiber to Prevent Obesity and Improve Glucose Homeostasis in Diet-Induced Obese Mice
作者	Zheng, Hong1,2; Ji, Hui 1; Fan, Kai1; Xu, Hangying 1; Huang, Yinli 2; Zheng, Yafei 1; Xu, Qingqing 1; Li, Chen 1; Zhao, Liangcai1; Li, Yuping3; Gao, Hongchang1,3
发表日期	2022-05
发表期刊	Molecular nutrition &food research 影响因子和分区
语种	英语
原始文献类型	Article
关键词	anti-obesity dietary fibers gut microbiota inflammation metabolic health.
其他关键词	INSULIN-RESISTANCE ; FAT ACCUMULATION ; INFLAMMATION ; POLYSACCHARIDES ; PROTECTS ; CHOLINE ; ADULTS ; TISSUE ; LIVER
摘要	Scope:Obesity is becoming a major public health problem due to excess dietary fat intake. Dendrobium officinale (D. officinale) is a medicine food homology plant and exerts multiple health-promoting effects. However, its antiobesity effects and the potential mechanisms remain unclear. Methods and results:High-fat diet (HFD)-fed mice are administered D. officinale dietary fiber (DODF) daily by gavage for 11 weeks. The results show that treatment with DODF alleviates obesity, liver steatosis, inflammation, and oxidant stress in HFD-induced obese mice. Improved glucose homeostasis in obese mice after DODF treatment is achieved by enhancing insulin pathway and hepatic glycogen synthesis. DODF restructures the gut microbiota in obese mice by decreasing the relative abundance of Bilophila and increasing the relative abundances of Akkermansia, Bifidobacterium, and Muribaculum. Also, DODF reshapes the metabolic phenotype of obese mice as indicated by up-regulating energy metabolism, increasing acetate and taurine, and reducing serum low density/very low density lipoproteins (LDL/VLDL). These beneficial effects are partly transferred by FMT, implying the gut microbiota as a target for the protective effect of DODF on obesity-related symptoms. Conclusion:The results suggest that DODF can be used as a novel prebiotics to maintain the gut microbial homeostasis and improve metabolic health, preventing obesity and related metabolic syndrome.
资助项目	National Natural Science Foundation of China[21575105];
出版者	WILEY
出版地	HOBOKEN
ISSN	1613-4125
EISSN	1613-4133
卷号	66 期号:10 页码:e2100772
DOI	10.1002/mnfr.202100772
页数	15
WOS类目	Food Science & Technology
WOS研究方向	Food Science & Technology
WOS记录号	WOS:000769480500001
收录类别	PUBMED ; SCOPUS ; SCIE
URL	查看原文
PubMed ID	35225418
SCOPUSEID	2-s2.0-85126273360
通讯作者地址	[Zheng, Hong]Institute of Metabonomics & Medical NMR,School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China ; [Gao, Hongchang]Institute of Metabonomics & Medical NMR,School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Biotechnology;Food Science
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/33113
专题	药学院（分析测试中心）附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_内科学_呼吸与危重症医学科其他_附属平阳医院（平阳县人民医院）
通讯作者	Zheng, Hong; Gao, Hongchang
作者单位	1.Institute of Metabonomics & Medical NMR,School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China; 2.Department of Endocrinology,Pingyang Affiliated Hospital of Wenzhou Medical University,Wenzhou,325400,China; 3.Department of Pulmonary and Critical Care Medicine,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325000,China
第一作者单位	药学院（分析测试中心）; 附属平阳医院（平阳县人民医院）
通讯作者单位	药学院（分析测试中心）
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Zheng, Hong,Ji, Hui,Fan, Kai,et al. Targeting Gut Microbiota and Host Metabolism with Dendrobium officinale Dietary Fiber to Prevent Obesity and Improve Glucose Homeostasis in Diet-Induced Obese Mice[J]. Molecular nutrition &food research,2022,66(10):e2100772.
APA	Zheng, Hong., Ji, Hui., Fan, Kai., Xu, Hangying., Huang, Yinli., ... & Gao, Hongchang. (2022). Targeting Gut Microbiota and Host Metabolism with Dendrobium officinale Dietary Fiber to Prevent Obesity and Improve Glucose Homeostasis in Diet-Induced Obese Mice. Molecular nutrition &food research, 66(10), e2100772.
MLA	Zheng, Hong,et al."Targeting Gut Microbiota and Host Metabolism with Dendrobium officinale Dietary Fiber to Prevent Obesity and Improve Glucose Homeostasis in Diet-Induced Obese Mice".Molecular nutrition &food research 66.10(2022):e2100772.