被撤回的出版物: FAM172A expression in circulating tumor cells for prediction of high-risk subgroups of colorectal cancer(Retracted article. See vol. 10, pg. 2411, 2017)

doi:10.2147/OTT.S118346

科研成果详情

名称	被撤回的出版物: FAM172A expression in circulating tumor cells for prediction of high-risk subgroups of colorectal cancer(Retracted article. See vol. 10, pg. 2411, 2017)
作者	Xu, Chang 1; Zhang, Chunhong 2; Wang, Haowen 3; Yang, Han 3; Li, Gang3; Fei, Zhenghua3; Li, Wenfeng1,3,4
发表期刊	ONCOTARGETS AND THERAPY
语种	英语
原始文献类型	Article ; Retracted Publication
关键词	colorectal cancer circulating tumor cells epithelial-mesenchymal transition FAM172A
其他关键词	EPITHELIAL-MESENCHYMAL TRANSITION ; METASTATIC COLORECTAL-CANCER ; FOLLOW-UP ; CARCINOMA ; SURVIVAL ; DISEASE ; PROGRESSION ; PROGNOSIS ; MARKER ; ISET
摘要	Objectives: Previous studies used enumerated circulating tumor cells (CTCs) to predict prognosis and therapeutic effect in several types of cancers. However, increasing evidence showed that only enumerated CTCs were not enough to reflect the heterogeneity of tumors. Therefore, we classified different metastasis potentials of CTCs from colorectal cancer (CRC) patients to improve the accuracy of prognosis by CTCs. Methods: Blood samples were collected from 45 primary CRC patients. CTCs were enriched by blood filtration, and the RNA in situ hybridization method was used to identify and discriminate subgroups of CTCs. Later, FAM172A expression in individual CTCs was measured. Results: Three CTC subgroups (epithelial/biophenotypic/mesenchymal CTCs) were identified using epithelial-mesenchymal transition markers. In our research, mesenchymal CTCs significantly increased along with tumor progression, including developing distant metastasis and vascular invasion. Furthermore, FAM172A expression rate in mesenchymal CTCs was significantly higher than that in epithelial CTCs, which suggested that FAM172A may correlate with tumor malignancy. This hypothesis was further verified by FAM172A expression in mesenchymal CTCs strictly related to tumor aggressiveness factors. Finally, we revealed that mesenchymal CTCs and FAM172A expression may predict high-risk subgroups in stage II CRC. Conclusion: Our research proved that CTCs could serve as feasible surrogate samples to detect gene expression as a predictive biomarker for tumor evaluation.
出版者	DOVE MEDICAL PRESS LTD
出版地	ALBANY
ISSN	1178-6930
卷号	10
页码	1933-1939
DOI	10.2147/OTT.S118346
页数	7
WOS类目	Biotechnology & Applied Microbiology ; Oncology
WOS研究方向	Biotechnology & Applied Microbiology ; Oncology
WOS记录号	WOS:000397948600006
收录类别	SCIE
发布日期	2017-12-31
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/32999
专题	附属第一医院附属第一医院_药学部药学部
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Colorectal Surg, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Dept Pharm, Wenzhou, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 1, Dept Chemoradiotherapy, Wenzhou, Peoples R China; 4.Wenzhou Med Univ, Affiliated Hosp 1, Inst Translat Med, Lab Interdisciplinary Res, Wenzhou, Peoples R China
推荐引用方式 GB/T 7714	Xu, Chang,Zhang, Chunhong,Wang, Haowen,等. 被撤回的出版物: FAM172A expression in circulating tumor cells for prediction of high-risk subgroups of colorectal cancer(Retracted article. See vol. 10, pg. 2411, 2017). 2017.