Polyamine metabolism in rat myocardial ischemia-reperfusion injury

doi:10.1016/j.ijcard.2007.07.163

科研成果详情

名称	Polyamine metabolism in rat myocardial ischemia-reperfusion injury
作者	Han, Liping1,2; Xu, Changqing 1,3; Guo, Yimin2; Li, Hongzhu 1; Jiang, Chunming 1; Zhao, Yajun 1
发表期刊	INTERNATIONAL JOURNAL OF CARDIOLOGY
语种	英语
原始文献类型	Letter
关键词	Ischemia Reperfusion Heart Polyamines ODC SSAT
其他关键词	OVEREXPRESSION ; CELLS
摘要	This study was focused on investigating the involvement of polyamine metabolism in the myocardial ischemia-reperfusion injury (MIRI) in an in vivo rat model. A branch of the descending left coronary artery was occluded for 30 min followed by 2 h, 6 h, 12 h, and 24 h reperfusion. Then the expression of spermidine/spermine N1-acetyltransferase (SSAT) and ornithine decarboxylase (ODC) and the concentrations of polyamines were assessed. It was found that the expression of SSAT and ODC were upregulated after reperfusion and the concentrations of spermidine and spermine were significantly decreased, while putrescine concentration was significantly increased. The results suggest that MIRI may cause disturbance of polyamine metabolism, and it may play a critical role in MIRI. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30370577, 30470688]; Developing Foundation of Wenzhou Medical College; Researching Foundation of the Department of Education of Zhejiang Province
出版者	ELSEVIER IRELAND LTD
出版地	CLARE
ISSN	0167-5273
EISSN	1874-1754
卷号	132
期号	1
页码	142-144
DOI	10.1016/j.ijcard.2007.07.163
页数	4
WOS类目	Cardiac & Cardiovascular Systems
WOS研究方向	Cardiovascular System & Cardiology
WOS记录号	WOS:000262978900027
收录类别	SCIE
发布日期	2009-02-06
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/32275
专题	基础医学院（机能实验教学中心）_机能学系_生理学
通讯作者	Xu, Changqing
作者单位	1.Harbin Med Coll, Dept Pathophysiol, Harbin 150086, Peoples R China; 2.Wenzhou Med Coll, Dept Physiol, Wenzhou 325035, Peoples R China; 3.Biopharmaceut Key Lab Heilongjiang Prov, Harbin 150086, Peoples R China
第一作者单位	基础医学院（机能实验教学中心）_机能学系_生理学
推荐引用方式 GB/T 7714	Han, Liping,Xu, Changqing,Guo, Yimin,et al. Polyamine metabolism in rat myocardial ischemia-reperfusion injury. 2009.