Lin28 modulates cell growth and associates with a subset of cell cycle regulator mRNAs in mouse embryonic stem cells

doi:10.1261/rna.1368009

科研成果详情

名称	Lin28 modulates cell growth and associates with a subset of cell cycle regulator mRNAs in mouse embryonic stem cells
作者	Xu, Bingsen 1,2; Zhang, Kexiong 1; Huang, Yingqun 1
发表期刊	RNA
语种	英语
原始文献类型	Letter
关键词	Lin28 cell cycle RNP embryonic stem cell
其他关键词	LIN-28 ; TRANSLATION
摘要	Lin28 is highly expressed in human and mouse embryonic stem ( ES) cells. Here, we show that in mouse ES cells, specific repression of Lin28 results in decreased cell proliferation, while overexpression of Lin28 accelerates cell proliferation. Further, Lin28 associates specifically with ribonucleoprotein particles containing mRNAs for cyclins A and B and cdk4. Importantly, changes in Lin28 levels lead to corresponding changes in the levels of these proteins, and sequences from the 3' untranslated regions of cyclin B and cdk4 mRNAs exhibit stimulatory effects on translation of reporter genes in a Lin28-dependent fashion. Thus, we postulate that Lin28 may play a role in the regulation of translation of genes important for the growth and maintenance of pluripotent cells.
出版者	COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
出版地	COLD SPRING HARBOR
ISSN	1355-8382
EISSN	1469-9001
卷号	15
期号	3
页码	357-361
DOI	10.1261/rna.1368009
页数	5
WOS类目	Biochemistry & Molecular Biology
WOS研究方向	Biochemistry & Molecular Biology
WOS记录号	WOS:000263505100001
收录类别	SCIE
发布日期	2009-03
引用统计	被引频次：154[WOS] [WOS记录] [WOS相关记录]
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/32240
专题	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学_生殖医学中心
通讯作者	Huang, Yingqun
作者单位	1.Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, New Haven, CT 06511 USA; 2.Wenzhou Med Coll, Affiliated Hosp 1, Reprod Med Ctr, Wenzhou 325000, Zhejiang, Peoples R China
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学_生殖医学中心
推荐引用方式 GB/T 7714	Xu, Bingsen,Zhang, Kexiong,Huang, Yingqun. Lin28 modulates cell growth and associates with a subset of cell cycle regulator mRNAs in mouse embryonic stem cells. 2009.