LncRNA GATA6-AS inhibits cancer cell proliferation and promotes cancer cell apoptosis in cervical cancer by down-regulating miR-205

doi:10.1186/s12905-020-01082-7

科研成果详情

题名	LncRNA GATA6-AS inhibits cancer cell proliferation and promotes cancer cell apoptosis in cervical cancer by down-regulating miR-205
作者	Zhao, Xiaoying 1; Zheng, Huzhong 1; Chen, Jun 2
发表日期	2020-11-09
发表期刊	BMC WOMENS HEALTH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	CSCC GATA6-AS miR-205 Proliferation Apoptosis
其他关键词	IMPACT ; HPV
摘要	Background Dysregulated endothelial cell growth is involved in many types of human cancer, including cervical cancer. LncRNA GATA6-AS was reported to regulate endothelial cell growth, suggesting it might involve in cervical cancer. Our study was carried out to explore the involvement of GATA6-AS in cervical squamous cell carcinoma (CSCC), a subtype of cervical cancer. Methods To explore the expression of GATA6-AS, RT-qPCR was performed to detect GATA6-AS in plasma of 65 CSCC patients and 58 healthy females. To detect the expression of GATA6-AS, total RNAs were extracted. Results We found that plasma GATA6-AS expression was down-regulated in CSCC patients than that in healthy females, and HPV infection did not significantly affect the plasma expression of GATA6-AS. Moreover, we found that plasma GATA6-AS showed diagnostic values for CSCC by performing ROC curve analysis. The expression of miR-205 in plasma was also found to be up-regulated in CSCC patients than that in healthy females and inversely correlated with the expression of GATA6-AS in CSCC patients. Furthermore, over-expression of miR-205 did not significantly affect the expression of GATA6-AS in CSCC cells, while over-expression of GATA6-AS down-regulated miR-205 expression. In addition, GATA6-AS over-expression inhibited CSCC cell proliferation and promoted CSCC cell apoptosis, while miR-205 over-expression played opposite roles and attenuated the effects of GATA6-AS over-expression on CSCC cells. Conclusion Taken together, these results suggest that GATA6-AS may inhibit cell proliferation and promote cell apoptosis in CSCC by down-regulating miR-205.
资助项目	Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LY14H190003]
出版者	BMC
出版地	LONDON
ISSN	1472-6874
EISSN	1472-6874
卷号	20 期号:1 页码:247
DOI	10.1186/s12905-020-01082-7
页数	6
WOS类目	Public, Environmental & Occupational Health ; Obstetrics & Gynecology
WOS研究方向	Public, Environmental & Occupational Health ; Obstetrics & Gynecology
WOS记录号	WOS:000590705700001
收录类别	SSCI ; SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	33167959
PMC记录号	PMC7650211
SCOPUSEID	2-s2.0-85095680296
社科自定义期刊分类	E类
通讯作者地址	[Chen, Jun]Department of Immunology,Wenzhou Medical University,Chashan higher Education Park,Wenzhou City,325000,China
Scopus学科分类	Reproductive Medicine;Obstetrics and Gynecology
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/3017
专题	基础医学院（机能实验教学中心）_病原生物学与免疫学系_医学免疫学
通讯作者	Chen, Jun
作者单位	1.Department of Gynaecology and Obstetrics,Wenzhou Hospital Of Integrated Traditional China & Med,Wenzhou City,325000,China; 2.Department of Immunology,Wenzhou Medical University,Chashan higher Education Park,Wenzhou City,325000,China
通讯作者单位	温州医科大学
推荐引用方式 GB/T 7714	Zhao, Xiaoying,Zheng, Huzhong,Chen, Jun. LncRNA GATA6-AS inhibits cancer cell proliferation and promotes cancer cell apoptosis in cervical cancer by down-regulating miR-205[J]. BMC WOMENS HEALTH,2020,20(1):247.
APA	Zhao, Xiaoying, Zheng, Huzhong, & Chen, Jun. (2020). LncRNA GATA6-AS inhibits cancer cell proliferation and promotes cancer cell apoptosis in cervical cancer by down-regulating miR-205. BMC WOMENS HEALTH, 20(1), 247.
MLA	Zhao, Xiaoying,et al."LncRNA GATA6-AS inhibits cancer cell proliferation and promotes cancer cell apoptosis in cervical cancer by down-regulating miR-205".BMC WOMENS HEALTH 20.1(2020):247.