Impact of seasons on stroke-related depression, mediated by vitamin D status

doi:10.1186/s12888-018-1944-z

科研成果详情

题名	Impact of seasons on stroke-related depression, mediated by vitamin D status
作者	Gu, Yingying1; Luan, Xiaoqian2; Ren, Wenwei 2; Zhu, Lin 3; He, Jincai2
发表日期	2018-11-08
发表期刊	BMC PSYCHIATRY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Season Depression Stroke Vitamin D Biomarker
其他关键词	SERUM 25-HYDROXYVITAMIN D ; D SUPPLEMENTATION ; ISCHEMIC-STROKE ; CLINICAL-TRIAL ; OLDER-ADULTS ; D DEFICIENCY ; SYMPTOMS ; METAANALYSIS ; DISORDER ; HEALTH
摘要	BackgroundThis study aimed to describe the seasonal variation of depression prevalence among stroke patients at 1month and to explore whether vitamin D plays a role in the association between seasons and post-stroke depression (PSD).MethodsData were collected from 402 acute stroke patients. Seasons were stratified by summertime (June to November) and wintertime (December to May) based on vitamin D status. The impact of seasons on PSD was assessed via binary logistic regression, with summertime considered the referent category. The mediating effect was used to evaluate whether vitamin D plays a role in the association between seasons and PSD.ResultsThe prevalence of PSD was significantly higher in the wintertime group than in the summertime group (P=0.003). The serum vitamin D level was lower in wintertime than in summertime (P<0.001). Lower vitamin D levels were associated with higher HAMD scores (P<0.001). In the multivariate analysis, patients in the wintertime group had a higher prevalence of PSD compared with those in the summertime group across all binary logistic regression models after adjusting for potential confounders. When serum vitamin D was added to the above model, there was no association between seasons and PSD (P=0.056). Vitamin D was independently associated with PSD (OR 0.95, 95% CI 0.935-0.966, P<0.001).ConclusionThere was a clear seasonal variation in depression prevalence among stroke patients. Vitamin D status plays a critical mediating role in the relationship between season and post-stroke depression.
资助项目	National Key Technology Research and Development Program of the Ministry of Science and Technology of ChinaNational Key Technology R&D Program [2015BAI13B01]; Wenzhou Municipal Sci-Tech Bureau Program [Y20160002]
出版者	BMC
出版地	LONDON
ISSN	1471-244X
卷号	18 期号:1 页码:359
DOI	10.1186/s12888-018-1944-z
页数	7
WOS类目	Psychiatry
WOS研究方向	Psychiatry
WOS记录号	WOS:000449864000001
收录类别	SSCI ; SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	30409201
PMC记录号	PMC6225690
SCOPUSEID	2-s2.0-85056407746
通讯作者地址	[He, Jincai]Department of Neurology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang Province,325000,China
Scopus学科分类	Psychiatry and Mental Health
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2982
专题	附属第一医院附属第一医院_儿科第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
通讯作者	He, Jincai
作者单位	1.Department of Psychiatry,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang Province,325000,China; 2.Department of Neurology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang Province,325000,China; 3.Department of Pediatrics,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang Province,325000,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Gu, Yingying,Luan, Xiaoqian,Ren, Wenwei,et al. Impact of seasons on stroke-related depression, mediated by vitamin D status[J]. BMC PSYCHIATRY,2018,18(1):359.
APA	Gu, Yingying, Luan, Xiaoqian, Ren, Wenwei, Zhu, Lin, & He, Jincai. (2018). Impact of seasons on stroke-related depression, mediated by vitamin D status. BMC PSYCHIATRY, 18(1), 359.
MLA	Gu, Yingying,et al."Impact of seasons on stroke-related depression, mediated by vitamin D status".BMC PSYCHIATRY 18.1(2018):359.