Common and distinct global functional connectivity density alterations in patients with bipolar disorder with and without auditory verbal hallucination during major depressive episodes

doi:10.1007/s11682-019-00222-4

科研成果详情

题名	Common and distinct global functional connectivity density alterations in patients with bipolar disorder with and without auditory verbal hallucination during major depressive episodes
作者	Qiu, Lixue 1; Ye, Jaen 1; Ji, Feng 2; Li, Gang 3; Li, Gongying 2; Ma, Xiaoyan 4; Li, Ranli 4; Tian, Hongjun 4; Wang, Lina 4; Chen, Guangdong 4; Xu, Yong 5,6; Wang, Wenqiang 7; Jiang, Deguo 1; Pan, Jianshe 8; Zhuo, Chuanjun 1,2,4,5,6,7
发表日期	2020-12
发表期刊	BRAIN IMAGING AND BEHAVIOR 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Auditory verbal hallucination Bipolar disorder gFCD Wernicke area Broca area
其他关键词	BRAIN STRUCTURE ; SCHIZOPHRENIA ; FMRI ; LANGUAGE
摘要	Although an increasing number of studies has explored the neural mechanisms of auditory verbal hallucination (AVH) using many modalities, including neuroimaging, neurotransmitters, and electroencephalography, the etiology of AVH remains unclear. In this study, we investigated the neuroimaging characteristics of AVH in patients with bipolar disorder (BD) experiencing depressive episodes with and without AVH. For this study, we recruited 80 patients with BD and depressive status (40 with and 40 without AVH), and 40 healthy individuals. Their global functional connectivity density (gFCD) was screened by functional magnetic resonance imaging. Differences in gFCD among the three groups were tested using voxel-wise one-way analysis of covariance. Patients in both BD groups demonstrated increased gFCD in the central parietal lobe, insular lobe, and middle cingulate cortex, and decreased gFCD in the posterior parietal cortex, lateral prefrontal cortex, and occipital lobe (all bilateral). We defined these alterations as the common aberrant gFCD pattern for BD with and without AVH. Compared with the other two groups, patients in the BD with AVH group demonstrated increased gFCD in the Broca and Wernicke regions, and decreased gFCD in the hippocampus (all bilateral). We defined these alterations as the distinct aberrant gFCD pattern for BD with AVH. To our knowledge, this report is the first to date to describe gFCD alterations in patients with BD with and without AVH. Our findings suggest that disturbances in brain activity and information communication capacity in patients with BD and AVH are located mainly in the left frontoparietal network, control network, and memory circuit. However, these observations were made only in patients with BD during depressive episodes, and without consideration of many factors, such as the treatment mode, symptom relapse, and BD subtype. Hence, the conclusions of this study merely provide clues for further study, and do not fully represent brain alterations in patients with BD and AVH. Further large-sample cohort studies are needed to clarify and expand on these findings.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81871052, 81801679, 81571319]; Key Projects of the Natural Science Foundation of Tianjin, China [17JCZDJC35700]; Tianjin Health Bureau Foundation [2014KR02]; Tianjin Anding Hospital Award [300000]; National Key Research and Development Program of China [2016YFC1307004]; Shanxi Science and Technology Innovation Training Team's Multidisciplinary Team for Cognitive Impairment [201705D131027]; Zhejiang Public Welfare Fund Project [LGF18H090002]; key project of the Wenzhou Science and Technology Bureau [ZS2017011]
出版者	SPRINGER
出版地	NEW YORK
ISSN	1931-7557
EISSN	1931-7565
卷号	14 期号:6 页码:2724-2730
DOI	10.1007/s11682-019-00222-4
页数	7
WOS类目	Neuroimaging
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000574093500004
收录类别	SSCI ; SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	31900890
SCOPUSEID	2-s2.0-85077574299
通讯作者地址	[Zhuo, Chuanjun]Psychiatric-Neuroimaging-Genetics-Comorbidity Laboratory,Tianjin Mental Health Centre,Mental Health Teaching Hospital of Tianjin Medical University,Tianjin Anding Hospital,Tianjin,300222,China
Scopus学科分类	Radiology, Nuclear Medicine and Imaging;Neurology;Neurology (clinical);Cognitive Neuroscience;Cellular and Molecular Neuroscience;Psychiatry and Mental Health;Behavioral Neuroscience
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2912
专题	其他_附属康宁医院（温州市康宁医院）第一临床医学院（信息与工程学院）、附属第一医院_精神病与精神卫生学
通讯作者	Zhuo, Chuanjun
作者单位	1.Psychiatric-Neuroimaging-Genetics Laboratory,Wenzhou Seventh People’s Hospital,Wenzhou,325000,China; 2.School of Mental Health,Jining Medical University,Jining,272119,China; 3.Department of Psychiatry,Tianshui Third Hospital,Tianshui,741000,China; 4.Psychiatric-Neuroimaging-Genetics-Comorbidity Laboratory,Tianjin Mental Health Centre,Mental Health Teaching Hospital of Tianjin Medical University,Tianjin Anding Hospital,Tianjin,300222,China; 5.Department of Psychiatry,First Hospital/First Clinical Medical College of Shanxi Medical University,Taiyuan,China; 6.MDT Center for Cognitive Impairment and Sleep Disorders,First Hospital of Shanxi Medical University,Taiyuan,030001,China; 7.Co-collaboration Laboratory of China and Canada,Xiamen Xianyue Hospital and University of Alberta,Xiamen,361000,China; 8.Department of Psychiatry,Wenzhou Kangning Hospital,Wenzhou Medical University Affiliated Wenzhou kangning Hospital,Zhejiang Province,325002,China
推荐引用方式 GB/T 7714	Qiu, Lixue,Ye, Jaen,Ji, Feng,et al. Common and distinct global functional connectivity density alterations in patients with bipolar disorder with and without auditory verbal hallucination during major depressive episodes[J]. BRAIN IMAGING AND BEHAVIOR,2020,14(6):2724-2730.
APA	Qiu, Lixue., Ye, Jaen., Ji, Feng., Li, Gang., Li, Gongying., ... & Zhuo, Chuanjun. (2020). Common and distinct global functional connectivity density alterations in patients with bipolar disorder with and without auditory verbal hallucination during major depressive episodes. BRAIN IMAGING AND BEHAVIOR, 14(6), 2724-2730.
MLA	Qiu, Lixue,et al."Common and distinct global functional connectivity density alterations in patients with bipolar disorder with and without auditory verbal hallucination during major depressive episodes".BRAIN IMAGING AND BEHAVIOR 14.6(2020):2724-2730.