Effects of omega-3 fatty acids on metabolic syndrome in patients with schizophrenia: a 12-week randomized placebo-controlled trial

doi:10.1007/s00213-018-5136-9

科研成果详情

题名	Effects of omega-3 fatty acids on metabolic syndrome in patients with schizophrenia: a 12-week randomized placebo-controlled trial
作者	Xu, Feikang 1; Fan, Weixing 2; Wang, Weiping 2; Tang, Wei 3; Yang, Fuyin 3,4; Zhang, Yi 1; Cai, Jun 1; Song, Lisheng 1; Zhang, Chen 1,3
发表日期	2019-04
发表期刊	PSYCHOPHARMACOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Olanzapine Omega-3 fatty acid TNF-alpha Metabolic syndrome RCT
其他关键词	TUMOR-NECROSIS-FACTOR ; POLYUNSATURATED FATTY-ACIDS ; MAJOR DEPRESSIVE DISORDER ; TNF-ALPHA ; OLANZAPINE ; DISEASE ; OBESITY ; SUPPLEMENTATION ; PREVALENCE ; MECHANISMS
摘要	RationaleIndividuals with schizophrenia are at increased risk of developing metabolic syndrome (MetS) due to their lifestyle and antipsychotic treatment. Our previous study showed that patients with both schizophrenia and MetS present an increased expression and production of tumor necrosis factor-alpha (TNF-alpha). Omega-3 fatty acids have a documented role in suppressing TNF-alpha; therefore, we hypothesized that they may be of value in relieving inflammation and improving metabolic disturbance in patients with both schizophrenia and MetS.ObjectivesThis study employed a randomized placebo-controlled trial to investigate the effects of omega-3 fatty acids on MetS in patients with schizophrenia.MethodsWe recruited 80 patients with both schizophrenia and MetS who received long-term olanzapine monotherapy. The patients were randomly assigned to the OMG-3 group (n=40) or the placebo group (n=40).ResultsPatients with both schizophrenia and MetS had significantly higher levels of TNF-alpha than the control subjects (Z=-4.37, P<0.01). There was a significant correlation between omega-3 fatty acid treatment and reduced triglyceride (TG) levels (F-groupxtime=13.42; df=1, 66; P<0.01) when the patients completed this study. Along with metabolic improvement, omega-3 fatty acids decreased TNF-alpha levels after 12weeks of treatment (F-groupxtime=6.71; df=1, 66; P=0.012). We also found that the extent of TNF-alpha decrease was significantly correlated with that of TG decrease (r=0.38, P=0.001).ConclusionsOur findings provide suggestive evidence that omega-3 fatty acids have beneficial effects on TG metabolism in patients with both schizophrenia and MetS that parallel decreased inflammation levels.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81471358, 81771450]; Shanghai Science and Technology Commission Foundation [14411969000]; Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support [20152530]; Shanghai Municipal Commission of Health and Family Planning Foundation [201540029]; Shanghai Municipal Commission of Health and Family Planning, Key Developing Disciplines [2015ZB0405]
出版者	SPRINGER
出版地	NEW YORK
ISSN	0033-3158
EISSN	1432-2072
卷号	236 期号:4 页码:1273-1279
DOI	10.1007/s00213-018-5136-9
页数	7
WOS类目	Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号	WOS:000472981400014
收录类别	SSCI ; SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	30519766
SCOPUSEID	2-s2.0-85057997898
通讯作者地址	[Zhang, Chen]Department of Psychiatry,Wenzhou Kangning Hospital,Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Pharmacology
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2781
专题	其他_附属康宁医院（温州市康宁医院）第一临床医学院（信息与工程学院）、附属第一医院_精神病与精神卫生学
通讯作者	Zhang, Chen
作者单位	1.Schizophrenia Program,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China; 2.Department of Psychiatry,Jinhua Second Hospital,Jinhua,China; 3.Department of Psychiatry,Wenzhou Kangning Hospital,Wenzhou Medical University,Wenzhou,China; 4.Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education),School of Psychology and Cognitive Science,East China Normal University,Shanghai,China
通讯作者单位	精神病与精神卫生学
推荐引用方式 GB/T 7714	Xu, Feikang,Fan, Weixing,Wang, Weiping,et al. Effects of omega-3 fatty acids on metabolic syndrome in patients with schizophrenia: a 12-week randomized placebo-controlled trial[J]. PSYCHOPHARMACOLOGY,2019,236(4):1273-1279.
APA	Xu, Feikang., Fan, Weixing., Wang, Weiping., Tang, Wei., Yang, Fuyin., ... & Zhang, Chen. (2019). Effects of omega-3 fatty acids on metabolic syndrome in patients with schizophrenia: a 12-week randomized placebo-controlled trial. PSYCHOPHARMACOLOGY, 236(4), 1273-1279.
MLA	Xu, Feikang,et al."Effects of omega-3 fatty acids on metabolic syndrome in patients with schizophrenia: a 12-week randomized placebo-controlled trial".PSYCHOPHARMACOLOGY 236.4(2019):1273-1279.