Association between gonadal hormones and osteoporosis in schizophrenia patients undergoing risperidone monotherapy: a cross-sectional study

doi:10.7717/peerj.11332

科研成果详情

题名	Association between gonadal hormones and osteoporosis in schizophrenia patients undergoing risperidone monotherapy: a cross-sectional study
作者	Chen, Yi 1; Zhang, Yaoyao2; Fan, Kaili 2; Xu, Weiqian 3; Teng, Chao 4; Wang, Shuangshuang 5; Tang, Wei 1,2; Zhu, Xiaomin 5
发表日期	2021-04-26
发表期刊	PEERJ 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Schizophrenia Risperidone Gonadal hormone Osteoporosis Bone mineral density
其他关键词	BONE-MINERAL DENSITY ; PROLACTIN ; ANTIPSYCHOTICS ; PREVALENCE ; OLANZAPINE ; TURNOVER ; RISK
摘要	Objective. Patients with schizophrenia are at increased risk of osteoporosis. This study first determined the osteoporosis rate in patients with schizophrenia and then then explored the association between serum gonadal hormone levels and osteoporosis among these patients. Methods. A total of 250 patients with schizophrenia and 288 healthy controls were recruited. Osteoporosis was defined by decreased bone mineral density (BMD) of the calcaneus. Serum fasting levels of gonadal hormones (prolactin, estradiol, testosterone, progesterone, follicle-stimulating hormone, luteinizing hormone) were determined. The relationship between osteoporosis and hormone levels was statistically analyzed by binary logistic regression analysis. Results. Our results showed that patients with schizophrenia had a markedly higher rate of osteoporosis (24.4% vs. 10.1%) than healthy controls (P < 0:001). Patients with osteoporosis were older, had a longer disease course, and had a lower body mass index (BMI) than patients without osteoporosis (all P < 0.05). Regarding gonadal hormones, we found significantly higher prolactin, but lower estradiol, levels in patients with osteoporosis than in those without osteoporosis (both P < 0.05). The regression analysis revealed that PRL (OR D 1.1, 95% CI [1.08-1.15], P < 0.001) and E2 level (OR D 0.9, 95%CI [0.96=.99], P D 0.011) were significantly associated with osteoporosis in patients with schizophrenia. Conclusion. Our results indicate that patients with schizophrenia who are being treated with risperidone have a high rate of osteoporosis. Increased prolactin and reduced estradiol levels are significantly associated with osteoporosis.
资助项目	Wenzhou Basic Medical Science and Technology Project [Y20190478]; Natural Science Foundation of Jiangsu ProvinceNatural Science Foundation of Jiangsu Province [BK20180213]; Basic Medical Science and Technology Project of Zhejiang [2020KY926]
出版者	PEERJ INC
出版地	LONDON
ISSN	2167-8359
卷号	9 页码:e11332.
DOI	10.7717/peerj.11332
页数	12
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:000644892200007
收录类别	SSCI ; SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	33987015
PMC记录号	PMC8086585
SCOPUSEID	2-s2.0-85105030432
通讯作者地址	[Zhu, Xiaomin]Department of Psychiatry,Suzhou Guangji Hospital,Affiliated Guangji Hospital of Soochow University,Suzhou, Jiangsu,China
Scopus学科分类	Neuroscience (all);Biochemistry, Genetics and Molecular Biology (all);Agricultural and Biological Sciences (all)
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2758
专题	其他_附属康宁医院（温州市康宁医院）精神医学学院_精神医学系第一临床医学院（信息与工程学院）、附属第一医院_精神病与精神卫生学
通讯作者	Zhu, Xiaomin
作者单位	1.Department of Psychiatry,Affiliated Kangning Hospital,Wenzhou Medical University,Wenzhou, Zhejiang,China; 2.Department of Psychiatry,Wenzhou Medical University,Wenzhou, Zhejiang,China; 3.Department of Psychiatry,Second People’s Hospital of TaiZhou,Taizhou, Zhejiang,China; 4.Department of Psychiatry,Zhejiang Chinese Medical University,Hangzhou, Zhejiang,China; 5.Department of Psychiatry,Suzhou Guangji Hospital,Affiliated Guangji Hospital of Soochow University,Suzhou, Jiangsu,China
第一作者单位	附属康宁医院（温州市康宁医院）
第一作者的第一单位	附属康宁医院（温州市康宁医院）
推荐引用方式 GB/T 7714	Chen, Yi,Zhang, Yaoyao,Fan, Kaili,et al. Association between gonadal hormones and osteoporosis in schizophrenia patients undergoing risperidone monotherapy: a cross-sectional study[J]. PEERJ,2021,9:e11332..
APA	Chen, Yi., Zhang, Yaoyao., Fan, Kaili., Xu, Weiqian., Teng, Chao., ... & Zhu, Xiaomin. (2021). Association between gonadal hormones and osteoporosis in schizophrenia patients undergoing risperidone monotherapy: a cross-sectional study. PEERJ, 9, e11332..
MLA	Chen, Yi,et al."Association between gonadal hormones and osteoporosis in schizophrenia patients undergoing risperidone monotherapy: a cross-sectional study".PEERJ 9(2021):e11332..