Elevated triglyceride levels are associated with cognitive impairments among patients with major depressive disorder

doi:10.1016/j.comppsych.2017.03.007

科研成果详情

题名	Elevated triglyceride levels are associated with cognitive impairments among patients with major depressive disorder
作者	Shao, Tian Nan 1,2,3; Yin, Guang Zhong 2; Yin, Xiao Li 3; Wu, Jing Qin 2; Du, Xiang Dong 2; Zhu, Hong Liang 2; Liu, Jia Hong 3; Wang, Xiao Qiong 3; Xu, Dong Wu 4; Tang, Wen Jie 1; Hui, Li 1,2,3
发表日期	2017-05
发表期刊	COMPREHENSIVE PSYCHIATRY 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	SERUM-LIPID CONCENTRATIONS ; QUALITY-OF-LIFE ; METABOLIC SYNDROME ; UNIPOLAR DEPRESSION ; RISK-FACTORS ; HIPPOCAMPAL VOLUME ; INSULIN-RESISTANCE ; BIPOLAR DISORDER ; VERBAL MEMORY ; METAANALYSIS
摘要	Background: Cognitive deficits have been identified as one of core clinical symptoms of major depressive disorder (MDD). Accumulating evidence indicated that triglycerides (TG) might be associated with MDD and cognitive decline. Objective: This study examined whether patients with MDD had poorer cognitive functions than healthy controls, and further investigate whether TG levels were involved in MDD, and its cognitive impairments in a Han Chinese population. Method: 115 patients with MDD and 119 healthy controls were enrolled. Cognitive functions were assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and serum TG levels were examined using enzymatic colorimetry. Results: TG levels were higher in patients with MDD than healthy controls after controlling for the variables. Cognitive test scores were lower in patients with MDD than healthy controls except for visuospatial/constructional index after controlling for the variables. TG levels were negatively correlated with visuospatial/constructional score, delayed memory score and RBANS total score of MDD. Further multivariate regression analysis showed that TG levels were negatively associated with visuospatial/constructional score, attention score, delayed memory score and RBANS total score of MDD. Conclusions: Our findings supported that serum TG levels might be involved in MDD, and play an important role in cognitive impairments of MDD, especially in delayed memory. Moreover, patients with MDD experienced greater cognitive impairments than healthy controls except for visuospatial/constructional index. (C) 2017 Elsevier Inc. All rights reserved.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81501160]; Young Medical Talent of Jiangsu Province [QNRC2016228]; Wenzhou Municipal Sci-Tech Bureau Program [Y20160073]; Suzhou Key Diagnosis and Treatment Program [LCZX201615]; Jiangsu Province Natural Science Fund Project [BK20151197]; Suzhou Key Medical Center for Psychiatric Diseases [Szzx201509]; Zhejiang Province Rising Star in Medicine
出版者	W B SAUNDERS CO-ELSEVIER INC
出版地	PHILADELPHIA
ISSN	0010-440X
EISSN	1532-8384
卷号	75 页码:103-109
DOI	10.1016/j.comppsych.2017.03.007
页数	7
WOS类目	Psychiatry
WOS研究方向	Psychiatry
WOS记录号	WOS:000400225000014
收录类别	SSCI ; SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	28342378
SCOPUSEID	2-s2.0-85015896648
社科自定义期刊分类	D类
通讯作者地址	[Tang, Wen Jie]First School of Clinical Medicine,Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Clinical Psychology;Psychiatry and Mental Health
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2674
专题	第一临床医学院（信息与工程学院）、附属第一医院精神医学学院其他_附属康宁医院（温州市康宁医院）
通讯作者	Tang, Wen Jie
作者单位	1.First School of Clinical Medicine,Wenzhou Medical University,Suzhou Psychiatric Hospital,Suzhou,China; 2.Institute of Mental Health,Suzhou Psychiatric Hospital,The Affiliated Guangji Hospital of Soochow University,Suzhou,China; 3.Wenzhou Kangning Hospital,Kangning Hospital attached to Wenzhou Medical University,Wenzhou,China; 4.School of Mental Health,Wenzhou Medical University,Wenzhou,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Shao, Tian Nan,Yin, Guang Zhong,Yin, Xiao Li,et al. Elevated triglyceride levels are associated with cognitive impairments among patients with major depressive disorder[J]. COMPREHENSIVE PSYCHIATRY,2017,75:103-109.
APA	Shao, Tian Nan., Yin, Guang Zhong., Yin, Xiao Li., Wu, Jing Qin., Du, Xiang Dong., ... & Hui, Li. (2017). Elevated triglyceride levels are associated with cognitive impairments among patients with major depressive disorder. COMPREHENSIVE PSYCHIATRY, 75, 103-109.
MLA	Shao, Tian Nan,et al."Elevated triglyceride levels are associated with cognitive impairments among patients with major depressive disorder".COMPREHENSIVE PSYCHIATRY 75(2017):103-109.