Identification of TNFA influencing MDD risk and clinical features in Han Chinese

doi:10.1016/j.cyto.2020.155030

科研成果详情

题名	Identification of TNFA influencing MDD risk and clinical features in Han Chinese
作者	Zhao, Junxiong 1; Hua, Shen 1; Wang, Weiping 1; Fan, Weixing 1; Tang, Wei 2; Zhang, Yi 3; Zhang, Chen 1,3
发表日期	2020-05
发表期刊	CYTOKINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	TNF-alpha Major depressive disorder Polymorphism Somatic symptom
其他关键词	MAJOR DEPRESSIVE DISORDER ; BIPOLAR DISORDER ; UP-REGULATION ; ASSOCIATION ; CYTOKINES ; ALPHA ; GENE ; SUSCEPTIBILITY ; POLYMORPHISMS ; INFLAMMATION
摘要	Objective: Our recent genetic-neuroimaging study observed that the rs1799724 polymorphism within the TNFA gene encoding TNF-alpha selectively affects the anatomy of visual cortex in patients with MDD. In this study, we hypothesized that TNFA is risk factor to MDD, and TNFA rs1799724 polymorphism may be a susceptibility locus for this disorder and its clinical features. Methods: We enrolled 807 MDD samples and 822 healthy volunteers in Eastern China. There were 104 drug-naive first episode MDD patients recruited. The Hamilton Rating Scale for Depression -17 (HRSD-17) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were performed to evaluate the severity of depressive symptoms and cognitive function, respectively. Results: Patients with MDD have higher levels of TNFA than healthy controls (F = 20.78, P < 0.01). There were no significant differences in genotype or allele distributions of the rs1799724 polymorphism between the MDD and control groups. MDD patients with T/T or T/C genotypes of rs1799724 polymorphism have higher somatic factor and total scores of HAMD than those with C/C genotype. The patients with T/T or T/C genotypes have significantly higher TNFA mRNA levels than those with C/C genotype (F = 4.91, P = 0.029). Conclusion: Our findings supported that TNFA may have an important role in the pathophysiology of MDD. Although SNP rs1799724 is not an etiological factor for MDD in Han Chinese, this SNP may be associated with somatic symptom in patients with MDD.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81471358, 81671326]; Shanghai Science and Technology Commission Foundation [19411969300]
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
出版地	LONDON
ISSN	1043-4666
EISSN	1096-0023
卷号	129 页码:155030
DOI	10.1016/j.cyto.2020.155030
页数	5
WOS类目	Biochemistry & Molecular Biology ; Cell Biology ; Immunology
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology ; Immunology
WOS记录号	WOS:000527732100005
收录类别	SSCI ; SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	32050144
SCOPUSEID	2-s2.0-85078978629
通讯作者地址	[Zhang, Chen]Shanghai Key Laboratory of Psychotic Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China
Scopus学科分类	Immunology and Allergy;Immunology;Biochemistry;Hematology;Molecular Biology
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2653
专题	其他_附属康宁医院（温州市康宁医院）第一临床医学院（信息与工程学院）、附属第一医院_精神病与精神卫生学
通讯作者	Zhang, Chen
作者单位	1.Department of Psychiatry,Jinhua Second Hospital,Zhejiang,China; 2.Department of Psychiatry,Wenzhou Kangning Hospital,Wenzhou Medical University,Zhejiang,China; 3.Shanghai Key Laboratory of Psychotic Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China
推荐引用方式 GB/T 7714	Zhao, Junxiong,Hua, Shen,Wang, Weiping,et al. Identification of TNFA influencing MDD risk and clinical features in Han Chinese[J]. CYTOKINE,2020,129:155030.
APA	Zhao, Junxiong., Hua, Shen., Wang, Weiping., Fan, Weixing., Tang, Wei., ... & Zhang, Chen. (2020). Identification of TNFA influencing MDD risk and clinical features in Han Chinese. CYTOKINE, 129, 155030.
MLA	Zhao, Junxiong,et al."Identification of TNFA influencing MDD risk and clinical features in Han Chinese".CYTOKINE 129(2020):155030.