Quantitative tractography reveals changes in the corticospinal tract in drug-naive children with attention-deficit/hyperactivity disorder

doi:10.1503/jpn.190024

科研成果详情

题名	Quantitative tractography reveals changes in the corticospinal tract in drug-naive children with attention-deficit/hyperactivity disorder
作者	Bu, Xuan 1; Yang, Chuang2; Liang, Kaili 1; Lin, Qingxia2; Lu, Lu 1; Zhang, Lianqing 1; Li, Hailong 1; Gao, Yingxue 1; Tang, Shi 1; Hu, Xiaoxiao 1; Wang, Yanlin 1; Hu, Xinyu 1; Wang, Meihao3; Huang, Xiaoqi 1
发表日期	2020-03
发表期刊	JOURNAL OF PSYCHIATRY & NEUROSCIENCE 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	DEFICIT HYPERACTIVITY DISORDER ; WHITE-MATTER ABNORMALITIES ; DIFFUSION ; ADHD ; PERFORMANCE ; MECHANISMS ; MRI
摘要	Background The specific role of the corticospinal tract with respect to inattention and impulsive symptoms in children with attentiondeficit/hyperactivity disorder (ADHD) has been explored in the past. However, to our knowledge, no study has identified the exact regions of the corticospinal tract that are affected in ADHD. We aimed to determine comprehensive alterations in the white matter microstructure of the corticospinal tract and underlying neuropsychological substrates in ADHD. Methods We recruited 38 drug-naive children with ADHD and 34 typically developing controls. We employed a tract-based quantitative approach to measure diffusion parameters along the trajectory of the corticospinal tract, and we further correlated alterations with attention and response inhibition measures. Results Compared with controls, children with ADHD demonstrated significantly lower fractional anisotropy and higher radial diffusivity at the level of cerebral peduncle, and higher fractional anisotropy at the level of the posterior limb of the internal capsule in the right corticospinal tract only. As well, increased fractional anisotropy in the posterior limb of the internal capsule was negatively correlated with continuous performance test attention quotients and positively correlated with reaction time on the Stroop Colour-Word Test; increased radial diffusivity in the right peduncle region was positively correlated with omissions in the Stroop test. Limitations The sample size was relatively small. Moreover, we did not consider the different subtypes of ADHD and lacked sufficient power to analyze subgroup differences. Higher-order diffusion modelling is needed in future white matter studies. Conclusion We demonstrated specific changes in the right corticospinal tract in children with ADHD. Correlations with measures of attention and response inhibition underscored the functional importance of corticospinal tract disturbance in ADHD.
资助项目	National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [81671669]; Science and Technology Project of Sichuan Province [2017JQ0001]
出版者	CMA-CANADIAN MEDICAL ASSOC
出版地	OTTAWA
ISSN	1180-4882
EISSN	1488-2434
卷号	45 期号:2 页码:134-141
DOI	10.1503/jpn.190024
页数	8
WOS类目	Neurosciences ; Psychiatry
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS记录号	WOS:000590535600008
收录类别	SSCI ; SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	31765114
PMC记录号	PMC7828908
SCOPUSEID	2-s2.0-85083321996
社科自定义期刊分类	D类
通讯作者地址	[Huang, Xiaoqi]Huaxi MR Research Center (HMRRC),Department of Radiology,Sichuan University West China Hospital,37 Guo Xue Xiang,Chengdu,610041,China
Scopus学科分类	Psychiatry and Mental Health;Biological Psychiatry;Pharmacology (medical)
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2639
专题	精神医学学院_精神医学系附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_精神病与精神卫生学第一临床医学院（信息与工程学院）、附属第一医院_影像医学与核医学_放射科
通讯作者	Huang, Xiaoqi
作者单位	1.Huaxi MR Research Center (HMRRC),Department of Radiology,Sichuan University West China Hospital,37 Guo Xue Xiang,Chengdu,610041,China; 2.Department of Psychiatry,Wenzhou Medical University First Affiliated Hospi-tal,Nan Bai Xiang,Wenzhou,325003,China; 3.Department of Radiology,Wenzhou Medical University First Affiliated Hospital,Nan Bai Xiang,Wenzhou,325003,China
推荐引用方式 GB/T 7714	Bu, Xuan,Yang, Chuang,Liang, Kaili,et al. Quantitative tractography reveals changes in the corticospinal tract in drug-naive children with attention-deficit/hyperactivity disorder[J]. JOURNAL OF PSYCHIATRY & NEUROSCIENCE,2020,45(2):134-141.
APA	Bu, Xuan., Yang, Chuang., Liang, Kaili., Lin, Qingxia., Lu, Lu., ... & Huang, Xiaoqi. (2020). Quantitative tractography reveals changes in the corticospinal tract in drug-naive children with attention-deficit/hyperactivity disorder. JOURNAL OF PSYCHIATRY & NEUROSCIENCE, 45(2), 134-141.
MLA	Bu, Xuan,et al."Quantitative tractography reveals changes in the corticospinal tract in drug-naive children with attention-deficit/hyperactivity disorder".JOURNAL OF PSYCHIATRY & NEUROSCIENCE 45.2(2020):134-141.