Highly Aligned Electrospun Collagen/Polycaprolactone Surgical Sutures with Sustained Release of Growth Factors for Wound Regeneration

doi:10.1021/acsabm.9b01000

科研成果详情

题名	Highly Aligned Electrospun Collagen/Polycaprolactone Surgical Sutures with Sustained Release of Growth Factors for Wound Regeneration
作者	Hu, Jinyu3; Song, Yi 3; Zhang, Cuiyun 3; Huang, Wen 3; Chen, Anqi 3; He, Huacheng 1; Zhang, Susu3; Chen, Yanxin 2; Tu, Chaodong 3; Liu, Jianhui 3; Xuan, Xuan3; Chang, Yung 4; Zheng, Jie 2; Wu, Jiang3
发表日期	2020-02-17
发表期刊	ACS APPLIED BIO MATERIALS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	suture sustained release growth factor electrospinning wound healing
其他关键词	FIBROUS SCAFFOLDS ; BFGF ; NANOFIBERS ; DELIVERY ; ANGIOGENESIS ; COMPOSITE ; VEGF
摘要	Development of biocompatible and bioactive drug-loaded sutures is considered as an effective but challenging strategy for the wound healing process by delivering biological drugs (e.g., antibiotics) or growth factors (e.g., bFGF) at the surgical wound sites. Conventional offline suture strategies often lead to fast and uncontrollable release of drugs at wound sites, rendering wound healing to become a longer and painful process for patients. Herein, we propose an online suture strategy to fabricate electrospun polycaprolactone (PCL) fibrous yarns, incorporated with both collagen (COL) and bFGF, to produce bFGF-COL@PCL sutures. Upon demonstrating the well-oriented and aligned fibrous microstructure, high mechanical properties, and controlled release of bFGF from bFGF-COL@PCL sutures in vitro, we then applied bFGF-COL@PCL sutures to an incision wound healing mouse model in vivo. Further in vivo study showed that as compared to the commercialized Vicryl suture, bFGF-COL@PCL sutures significantly promoted the wound healing at different stages by accelerating granulation tissue formation, collagen deposition, and re-epithelialization. The enhanced wound healing efficiency of bFGF-COL@PCL sutures is likely attributed to two synergistic factors: (i) the well-oriented nanofibrous structure reduces tissue drag to minimize their trauma and (ii) the presence of both collagen and bFGF enhances the basement membrane (BM) reconstruction, cell proliferation, and angiogenesis. This work demonstrates an effective suture strategy and system for surgical suture applications.
资助项目	Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LGF19H180008]; National Natural Science Funding of ChinaNational Natural Science Foundation of China (NSFC) [81601615, NSF-1806138]; Zhejiang Qianjiang Talent Project [QJD1803015]
出版者	AMER CHEMICAL SOC
出版地	WASHINGTON
ISSN	2576-6422
EISSN	2576-6422
卷号	3 期号:2 页码:965-976
DOI	10.1021/acsabm.9b01000
页数	12
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Biomaterials
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS记录号	WOS:000616372700020
收录类别	ESCI ; PUBMED ; EI ; SCOPUS
EI入藏号	20201508386346
EI主题词	Controlled drug delivery
URL	查看原文
Pubmed记录号	35019298
Scopus记录号	2-s2.0-85082671321
通讯作者地址	[He, Huacheng]College of Chemistry and Materials Engineering,Wenzhou University,Wenzhou,325027,China
scopus学科分类	Biomaterials;Chemistry (all);Biomedical Engineering;Biochemistry (medical)
引用统计	被引频次：26[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2570
专题	药学院（分析测试中心）_生物制药系_生物制药工程附属第一医院
通讯作者	He, Huacheng
作者单位	1.College of Chemistry and Materials Engineering,Wenzhou University,Wenzhou,325027,China; 2.Department of Chemical and Biomolecular Engineering,University of Akron,Akron,44325,United States; 3.Key Laboratory of Biotechnology and Pharmaceutical Engineering,School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China; 4.R & D Center for Membrane Technology and Department of Chemical Engineering,Chung Yuan Christian University,Chung,Li 320,Taiwan
第一作者单位	药学院（分析测试中心）
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Hu, Jinyu,Song, Yi,Zhang, Cuiyun,et al. Highly Aligned Electrospun Collagen/Polycaprolactone Surgical Sutures with Sustained Release of Growth Factors for Wound Regeneration[J]. ACS APPLIED BIO MATERIALS,2020,3(2):965-976.
APA	Hu, Jinyu., Song, Yi., Zhang, Cuiyun., Huang, Wen., Chen, Anqi., ... & Wu, Jiang. (2020). Highly Aligned Electrospun Collagen/Polycaprolactone Surgical Sutures with Sustained Release of Growth Factors for Wound Regeneration. ACS APPLIED BIO MATERIALS, 3(2), 965-976.
MLA	Hu, Jinyu,et al."Highly Aligned Electrospun Collagen/Polycaprolactone Surgical Sutures with Sustained Release of Growth Factors for Wound Regeneration".ACS APPLIED BIO MATERIALS 3.2(2020):965-976.