Thrombin Embedded in eMPs@Thr/Sponge with Enhanced Procoagulant Ability for Uncompressible and Massive Hemorrhage Control

doi:10.1021/acsabm.1c00882

科研成果详情

题名	Thrombin Embedded in eMPs@Thr/Sponge with Enhanced Procoagulant Ability for Uncompressible and Massive Hemorrhage Control
作者	Liu, Wen 1,2; Yang, Xiao 1,2; Li, Pengpeng 3; Sang, Feng3; Cao, Lina3; Zhang, Bingxu3; Meng, Zhizhen4; Ma, Zhaipu 5; Shi, Changcan 1,2,3,4
发表日期	2021-10-18
发表期刊	ACS APPLIED BIO MATERIALS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	uncompressible hemorrhage thrombin encapsulating electrospraying microspheres expandable sponge
其他关键词	NONCOMPRESSIBLE HEMORRHAGE ; CHITOSAN ; ALGINATE ; EFFICACY ; SPONGE
摘要	Uncontrollable hemorrhage, especially uncompressible and massive hemorrhage, is life threatening. To develop a kind of hemostatic material that is biocompatible and has effective hemostatic performance, a starch-polyethylene glycol sponge (St-PEG sponge) incorporated with electrospraying microspheres made from carboxymethyl chitosan and sodium alginate (CMC/SA eMPs) is employed to fabricate the topical hemostatic agent for application. To load thrombin safely and effectively, CMC/SA eMPs encapsulating thrombin compounds (eMPs@Thr) are further incorporated with St-PEG sponge to obtain eMPs@Thr/sponge. The results show that eMPs@Thr/sponge could obviously reduce blood loss and shorten the hemostatis time compared with commercial hemostatic products Kuai Kang. The construction of the eMPs@Thr/sponge could not only maintain the expandable properties of the St-PEG sponge but also strengthen the procoagulant activity. Therefore, this work provides a facile approach for loading thrombin given the fact that thrombin suffers from instability and risk of thrombus. It is predicted that eMPs@Thr/sponge might hold great potential in uncompressible and massive hemorrhage control.
资助项目	Wenzhou Science and Technology Major Project [ZY2019018]; Zhejiang Province Welfare Technology Applied Research Project [LGF20E030003, LGF20C100002]; Wenzhou Institute, University of Chinese Academy of Sciences startup fund [WIUCASQD2019006]
出版者	AMER CHEMICAL SOC
出版地	WASHINGTON
ISSN	2576-6422
卷号	4 期号:10 页码:7643-7652
DOI	10.1021/acsabm.1c00882
页数	10
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Biomaterials
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS记录号	WOS:000710273300025
收录类别	ESCI ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	35006716
SCOPUSEID	2-s2.0-85116235384
通讯作者地址	[Shi, Changcan]Wenzhou Institute,University of Chinese Academy of Sciences,Zhejiang,Wenzhou,325011,China ; [Ma, Zhaipu]School of Life Sciences,Hebei University,Hebei,Baoding,071000,China
Scopus学科分类	Biomaterials;Chemistry (all);Biomedical Engineering;Biochemistry (medical)
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2565
专题	眼视光学院（生物医学工程学院）、附属眼视光医院附属第一医院仁济学院_眼视光、生物医学工程学部
通讯作者	Ma, Zhaipu; Shi, Changcan
作者单位	1.Wenzhou Institute,University of Chinese Academy of Sciences,Zhejiang,Wenzhou,325011,China; 2.Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Zhejiang,Wenzhou,325001,China; 3.School of Biomedical Engineering,Wenzhou Medical University,Zhejiang,Wenzhou,325027,China; 4.The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325000,China; 5.School of Life Sciences,Hebei University,Hebei,Baoding,071000,China
推荐引用方式 GB/T 7714	Liu, Wen,Yang, Xiao,Li, Pengpeng,et al. Thrombin Embedded in eMPs@Thr/Sponge with Enhanced Procoagulant Ability for Uncompressible and Massive Hemorrhage Control[J]. ACS APPLIED BIO MATERIALS,2021,4(10):7643-7652.
APA	Liu, Wen., Yang, Xiao., Li, Pengpeng., Sang, Feng., Cao, Lina., ... & Shi, Changcan. (2021). Thrombin Embedded in eMPs@Thr/Sponge with Enhanced Procoagulant Ability for Uncompressible and Massive Hemorrhage Control. ACS APPLIED BIO MATERIALS, 4(10), 7643-7652.
MLA	Liu, Wen,et al."Thrombin Embedded in eMPs@Thr/Sponge with Enhanced Procoagulant Ability for Uncompressible and Massive Hemorrhage Control".ACS APPLIED BIO MATERIALS 4.10(2021):7643-7652.