Combination therapy of tripterygium glycosides plus valsartan in diabetic nephropathy treatment: A systematic review and meta-analysis

doi:10.1016/j.chmed.2018.08.011

科研成果详情

题名	Combination therapy of tripterygium glycosides plus valsartan in diabetic nephropathy treatment: A systematic review and meta-analysis
作者	Ye, Wan-chun 1; Ye, Jian-zhong 2,3; Zheng, Cheng 4; He, Xiao-wei 5; Huang, Jia-jie 6; Ye, Ren6
发表日期	2019-04
发表期刊	CHINESE HERBAL MEDICINES 影响因子和分区
语种	英语
原始文献类型	Review
关键词	diabetic nephropathy meta-analysis tripterygium glycosides valsartan
其他关键词	RENAL-DISEASE ; MELLITUS ; TABLET
摘要	Objective: To assess the efficacy and safety of the combination therapy of Chinese herbal medicines, tripterygium glycosides, plus valsartan for the treatment of diabetic nephropathy (DN). Methods: A comprehensive research of 12 electronic databases was performed. Data of the included studies were extracted and analyzed independently by two authors, and were synthesized using Review Manager (version 5.2) and Stata (version 12.0). Results: A total of 12 randomized controlled trials (RCTs) involving 829 patients were included. Pooled results showed that the combination therapy significantly increased total efficacy of DN patients [RR = 1.35, 95% CI (1.22, 1.50), P < 0.001], the level of serum albumin [Mean difference (MD) = 3.87, 95% CI (3.12, 4.62), P < 0.001], and significantly decreased 24 h urinary protein level [MD = -0.97, 95% CI (-1.19, -0.76), P < 0.001], urinary albumin-excretion rate [MD = -145.53, 95% CI (-227.95, -63.11), P < 0.001], and urinary beta 2-microglobuli level [MD = -11.86, 95% CI (-13.02, -10.69), P < 0.001]. No significant differences were found in levels of serum creatinine [MD = -0.26, 95% CI (-7.52, 7.00), P > 0.05), blood urea nitrogen [MD = 0.25, 95% CI (-0.23, 0.74), P > 0.05], and endogenous creatinine clearance rate [MD = -0.43, 95% CI (-3.48, 2.62), P > 0.05]. However, tripterygium glycosides plus valsartan seemed to exert higher adverse reaction rate than valsartan monotherapy [MD = 3.41, 95% CI (1.34, 8.66), P < 0.05]. There were no publication bias for all of the pooled effect sizes. Conclusion: Combination therapy of tripterygium glycosides plus valsartan may be effective for the treatment of DN. However, the safety of the combination therapy need to be further confirmed. (C) 2019 Tianjin Press of Chinese Herbal Medicines. Published by Elsevier B.V. All rights reserved.
资助项目	Zhejiang Traditional Chinese Medicine Science and Technology Project [2016ZA139]
出版者	ELSEVIER SINGAPORE PTE LTD
出版地	SINGAPORE
ISSN	1674-6384
卷号	11 期号:2 页码:222-230
DOI	10.1016/j.chmed.2018.08.011
页数	9
WOS类目	Chemistry, Medicinal
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000468161000014
收录类别	ESCI
通讯作者地址	[Ye, Ren]Wenzhou Med Univ, Affiliated Hosp 1, Dept Tradit Chinese Med, Wenzhou 325000, Peoples R China.
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2552
专题	附属第二医院_耳鼻咽喉科附属第一医院_中医科
通讯作者	Ye, Ren
作者单位	1.Wenzhou Cent Hosp, Dept Chemotherapy 2, Wenzhou 325000, Peoples R China; 2.Zhejiang Univ, Coll Med, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, Hangzhou 310000, Zhejiang, Peoples R China; 3.Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310000, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Affiliated Hosp 2, Dept Cardiol, Wenzhou 325000, Peoples R China; 5.Guangxi Univ Chinese Med, Zhuang Med Coll, Nanning 530000, Peoples R China; 6.Wenzhou Med Univ, Affiliated Hosp 1, Dept Tradit Chinese Med, Wenzhou 325000, Peoples R China
通讯作者单位	附属第一医院_中医科
推荐引用方式 GB/T 7714	Ye, Wan-chun,Ye, Jian-zhong,Zheng, Cheng,et al. Combination therapy of tripterygium glycosides plus valsartan in diabetic nephropathy treatment: A systematic review and meta-analysis[J]. CHINESE HERBAL MEDICINES,2019,11(2):222-230.
APA	Ye, Wan-chun, Ye, Jian-zhong, Zheng, Cheng, He, Xiao-wei, Huang, Jia-jie, & Ye, Ren. (2019). Combination therapy of tripterygium glycosides plus valsartan in diabetic nephropathy treatment: A systematic review and meta-analysis. CHINESE HERBAL MEDICINES, 11(2), 222-230.
MLA	Ye, Wan-chun,et al."Combination therapy of tripterygium glycosides plus valsartan in diabetic nephropathy treatment: A systematic review and meta-analysis".CHINESE HERBAL MEDICINES 11.2(2019):222-230.

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