科研成果详情

题名Association between a polymorphism in miR-34b/c and susceptibility to cancer--a meta-analysis
作者
发表日期2014
发表期刊Asian Pacific journal of cancer prevention : APJCP   影响因子和分区
语种英语
原始文献类型Article
关键词miR-34b/c rs4938723 polymorphism cancer meta-analysis
其他关键词POTENTIALLY FUNCTIONAL POLYMORPHISM ; PROMOTER REGION ; RISK ; MICRORNA ; PRI-MIR-34B/C
摘要MicroRNAs (miRNAs) act as tumor suppressors or promoters in neoplasia by regulating relative gene expression. The association between a single nucleotide polymorphism (SNP) rs4938723 in miR-34b/c and susceptibility to cancers was inconsistent in previous studies. In this study, we conducted a literature search of PubMed, Web of Science and Embase to identify all relevant studies in this meta-analysis with 6,036 cases and 6,204 controls. We found that the miR-34b/c rs4938723 polymorphism was significantly associated with increased risk of cancers in the heterozygous model (TC versus TT, OR=1.09, 95% CI=1.01-1.18, P=0.02). Subgroup analysis also revealed increased risk for Asian ethnicity in the heterozygous model (TC versus TT, OR=1.12, 95% CI=1.02-1.22, P=0.02), but decreased risk of colorectal cancer in homozygote model (CC versus TT, OR=0.66, 95% CI=0.47-0.92, P=0.02) and in the recessive model (CC versus TC+TT, OR=0.67, 95% CI=0.48-0.93, P=0.02) by cancer type. The current meta-analysis indicated that the miR-34b/c rs4938723 polymorphism may decrease susceptibility to colorectal cancer. Well-designed studies with larger sample size are required to further validate the results.
出版者ASIAN PACIFIC ORGANIZATION CANCER PREVENTION
ISSN1513-7368
卷号15期号:17页码:7251-5.
DOI10.7314/apjcp.2014.15.17.7251
页数5
WOS类目Oncology
WOS研究方向Oncology
WOS记录号WOS:000343833100043
收录类别PUBMED ; SCIE ; SCOPUS
URL查看原文
PubMed ID25227823
SCOPUSEID2-s2.0-84907275754
通讯作者地址[Tang, Kai-Fu]Institute of Genomic Medicine, Wenzhou Medical University,Wenzhou,China
Scopus学科分类Epidemiology;Oncology;Public Health, Environmental and Occupational Health;Cancer Research
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/23036
专题附属第一医院
基因组医学研究院
通讯作者Tang, Kai-Fu
作者单位
1.Department of Infection and Liver Diseases, Institution of Hepatology, First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China;
2.Institute of Genomic Medicine, Wenzhou Medical University,Wenzhou,China
第一作者单位附属第一医院
通讯作者单位基因组医学研究院
第一作者的第一单位附属第一医院
推荐引用方式
GB/T 7714
Lin, Zhuo,Chen, Li,Song, Mei,et al. Association between a polymorphism in miR-34b/c and susceptibility to cancer--a meta-analysis[J]. Asian Pacific journal of cancer prevention : APJCP,2014,15(17):7251-5..
APA Lin, Zhuo, Chen, Li, Song, Mei, Shi, Ke-Qing, & Tang, Kai-Fu. (2014). Association between a polymorphism in miR-34b/c and susceptibility to cancer--a meta-analysis. Asian Pacific journal of cancer prevention : APJCP, 15(17), 7251-5..
MLA Lin, Zhuo,et al."Association between a polymorphism in miR-34b/c and susceptibility to cancer--a meta-analysis".Asian Pacific journal of cancer prevention : APJCP 15.17(2014):7251-5..

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