Whether the risk of gestational diabetes mellitus is affected by TNF-alpha, IL-6, IL-10 or ADIPOQ polymorphisms: a meta-analysis

doi:10.1186/s13098-020-00582-8

科研成果详情

题名	Whether the risk of gestational diabetes mellitus is affected by TNF-alpha, IL-6, IL-10 or ADIPOQ polymorphisms: a meta-analysis
作者	Huang, Qiqi 1; Wang, Yi1; Gu, Binbin1; Xu, Yanwen 2
发表日期	2020-09-17
发表期刊	DIABETOLOGY & METABOLIC SYNDROME 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Gestational diabetes mellitus (GDM) Tumor necrosis factor-alpha (TNF-alpha) Interleukin-6 (IL-6) Interleukin-10 (IL-10) Adiponectin (ADIPOQ)
其他关键词	GENE POLYMORPHISMS ; ADIPONECTIN ; INFLAMMATION ; VARIANTS ; CYTOKINE
摘要	Background: Whether polymorphisms in tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-10 (IL-10) or adiponectin (ADIPOQ) influence the risk of gestational diabetes mellitus (GDM) or not remain inconclusive. Therefore, the authors conducted a meta-analysis to robustly assess relationships between polymorphisms in TNF-alpha, IL-6, IL-10 or ADIPOQ and the risk of GDM by merging the results of eligible publications. Methods: A through literature searching in Medline, Embase, Wanfang, VIP and CNKI was conducted by the authors to identify eligible publications, and twenty-two publications were finally found to be eligible for merged quantitative analyses. Results: The merged quantitative analyses revealed that ADIPOQ + 45T/G (rs2241766) polymorphism was significantly associated with the risk of GDM in overall population (dominant comparison: OR = 0.70, p < 0.001; recessive comparison: OR = 1.95, p < 0.001; over-dominant comparison: OR = 1.18, p = 0.03; allele comparison: OR = 0.71, p < 0.001) and Asians (dominant comparison: OR = 0.70, p < 0.001; recessive comparison: OR = 1.94, p < 0.001; allele comparison: OR = 0.72, p < 0.001). Nevertheless, we did not observe any positive results for TNF-alpha - 238G/A (rs361525), TNF-alpha - 308G/A (rs1800629), IL6 - 174G/C (rs1800795), IL-10 - 819C/T (rs1800871), IL-10 - 592C/A (rs1800872), IL-10 - 1082A/G (rs1800896) and ADIPOQ + 276G/T (rs1501299) polymorphisms. Conclusions: The present meta-analysis shows that among investigated TNF-alpha, IL-6, IL-10 or ADIPOQ polymorphisms, only ADIPOQ + 45T/G (rs2241766) polymorphism may affect the risk of GDM.
出版者	BMC
出版地	LONDON
ISSN	1758-5996
EISSN	1758-5996
卷号	12 期号:1 页码:81
DOI	10.1186/s13098-020-00582-8
页数	8
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:000574262200001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
Pubmed记录号	32963590
PMC记录号	PMC7499992
Scopus记录号	2-s2.0-85091776937
通讯作者地址	[Xu, Yanwen]Department of Endocrinology,Huzhou Hospital of Traditional Chinese Medicine,Zhejiang University of Traditional Chinese Medicine,No.315 of South Chaoyang Street,Huzhou,313000,China
scopus学科分类	Internal Medicine;Endocrinology, Diabetes and Metabolism
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2287
专题	附属第一医院_营养科
通讯作者	Xu, Yanwen
作者单位	1.Department of Nutrition,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Endocrinology,Huzhou Hospital of Traditional Chinese Medicine,Zhejiang University of Traditional Chinese Medicine,No.315 of South Chaoyang Street,Huzhou,313000,China
第一作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Huang, Qiqi,Wang, Yi,Gu, Binbin,et al. Whether the risk of gestational diabetes mellitus is affected by TNF-alpha, IL-6, IL-10 or ADIPOQ polymorphisms: a meta-analysis[J]. DIABETOLOGY & METABOLIC SYNDROME,2020,12(1):81.
APA	Huang, Qiqi, Wang, Yi, Gu, Binbin, & Xu, Yanwen. (2020). Whether the risk of gestational diabetes mellitus is affected by TNF-alpha, IL-6, IL-10 or ADIPOQ polymorphisms: a meta-analysis. DIABETOLOGY & METABOLIC SYNDROME, 12(1), 81.
MLA	Huang, Qiqi,et al."Whether the risk of gestational diabetes mellitus is affected by TNF-alpha, IL-6, IL-10 or ADIPOQ polymorphisms: a meta-analysis".DIABETOLOGY & METABOLIC SYNDROME 12.1(2020):81.