Prolactin Is Associated With Insulin Resistance and Beta-Cell Dysfunction in Infertile Women With Polycystic Ovary Syndrome

doi:10.3389/fendo.2021.571229

科研成果详情

题名	Prolactin Is Associated With Insulin Resistance and Beta-Cell Dysfunction in Infertile Women With Polycystic Ovary Syndrome
作者	Yang, Haiyan1; Lin, Jie 1; Li, He 2; Liu, Zhangwei1; Chen, Xia1; Chen, Qianqian 1
发表日期	2021-02-25
发表期刊	FRONTIERS IN ENDOCRINOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	prolactin infertility polycystic ovary syndrome (PCOS) insulin resistance beta-cell function
其他关键词	RISK
摘要	Background Our study aimed to investigate if serum prolactin (PRL) levels associated with insulin resistance and beta-cell dysfunction in infertile patients with polycystic ovary syndrome (PCOS). Methods This was a retrospective cross-sectional study performed in the reproductive medicine center of the first affiliated hospital of Wenzhou Medical University. From January 2007 to August 2018, a total of 792 PCOS and 700 non-PCOS infertile women were included. All patients' prolactin levels were in the normal range. PCOS was diagnosed according to the Rotterdam Criteria. Anthropometric parameters, blood pressure, serum prolactin levels, sex hormones, fasting lipids, fasting plasma glucose (FPG), fasting insulin (FINS) and hepatic biological parameters were measured in all subjects. Results Serum prolactin levels in PCOS women were significantly decreased compared with levels in non-PCOS women after adjusting for age and BMI (P < 0.05). Moreover, we found that prolactin levels were positively associated with high-density lipoprotein cholesterol (HDL-C) and negatively associated with age, BMI, waist circumference (WC), hip circumference (HC), luteinizing hormone/follicle stimulating hormone (LH/FSH), estradiol (E-2), FINS, homeostasis model assessment of insulin resistance (HOMA-IR), homeostasis model assessment of beta (HOMA-beta), triglyceride (TG) and alanine aminotransferase (ALT) (P < 0.05). After adjusting for age and BMI, multiple linear regression analysis revealed that LH, LH/FSH, E-2, FINS, HOMA-IR, and HOMA-beta were negatively associated with serum PRL (P < 0.05). Conclusions Low serum PRL levels within the normal range associates with a higher incidence of insulin resistance and beta-cell dysfunction in infertile women with PCOS.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81901551]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1664-2392
卷号	12 页码:571229
DOI	10.3389/fendo.2021.571229
页数	8
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:000627315700001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	33716958
PMC记录号	PMC7947819
SCOPUSEID	2-s2.0-85102459207
通讯作者地址	[Chen, Xia]Reproductive Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China ; [Chen, Qianqian]Reproductive Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Endocrinology, Diabetes and Metabolism
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2281
专题	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学_生殖医学中心附属第一医院
通讯作者	Chen, Xia; Chen, Qianqian
作者单位	1.Reproductive Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Shanghai Ji Ai Genetics and IVF Institute,Obstetrics and Gynecology Hospital,Fudan University,Shanghai,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 生殖医学中心
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 生殖医学中心
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Yang, Haiyan,Lin, Jie,Li, He,et al. Prolactin Is Associated With Insulin Resistance and Beta-Cell Dysfunction in Infertile Women With Polycystic Ovary Syndrome[J]. FRONTIERS IN ENDOCRINOLOGY,2021,12:571229.
APA	Yang, Haiyan, Lin, Jie, Li, He, Liu, Zhangwei, Chen, Xia, & Chen, Qianqian. (2021). Prolactin Is Associated With Insulin Resistance and Beta-Cell Dysfunction in Infertile Women With Polycystic Ovary Syndrome. FRONTIERS IN ENDOCRINOLOGY, 12, 571229.
MLA	Yang, Haiyan,et al."Prolactin Is Associated With Insulin Resistance and Beta-Cell Dysfunction in Infertile Women With Polycystic Ovary Syndrome".FRONTIERS IN ENDOCRINOLOGY 12(2021):571229.