Association of serum galectin3 levels with six-month functional outcome of severe traumatic brain injury and the mediation effect of acute lung injury: A two-center prospective cohort study

doi:10.1016/j.cca.2025.120189

科研成果详情

题名	Association of serum galectin3 levels with six-month functional outcome of severe traumatic brain injury and the mediation effect of acute lung injury: A two-center prospective cohort study
作者	Huayong Hong 1; Dongmin Cai 2; Xiaole Zhang 3; Xiaofeng Wang 4; Qin Xie 5; Juhui Lou 6; Jin Liu7; Da Tian 8; Xiaoyu Wu 9; Lixin Zhang 10
发表日期	2025-02-10
发表期刊	Clinica chimica acta; international journal of clinical chemistry 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Acute lung injury Biomarkers Galectin3 Mediations Outcome Traumatic brain injury
摘要	Severe traumatic brain injury (sTBI) is frequently complicated with acute lung injury (ALI). Galectin3 poses a pivotal role in acute brain injury and non-traumatic ALI. Here, serum galectin3 was quantified with an intent to unravel its prognostic significance and mediation effects of ALI in humans with sTBI., Serum galectin3 levels were detected in 295 patients with sTBI and 124 healthy subjects in this prospective cohort study. The Glasgow Coma Scale (GCS) scores and Rotterdam computed tomography (CT) scores were recorded. The extended Glasgow outcome scale (GOSE) scores of 1-4 at six-month mark after sTBI signified a poor prognosis. Results were verified by employing multivariate methods., Patients, relative to controls, exhibited pronouncedly incremental serum galectin3 levels. Serum galectin3 levels were linearly and independently relevant to GCS, Rotterdam CT, GOSE scores, and the likelihoods of ALI and poor prognosis. Serum galectin3 levels negligibly interacted with age, sex, hypertension, diabetes, smoking and alcohol habits in predicting ALI and poor prognosis. Serum galectin3 levels efficaciously discriminated probabilities of ALI and poor prognosis. Within the context of propensity score matching, a worse prognosis was evidently occupied by patients with higher serum galectin3 levels. Serum galectin3 levels, in conjunction with GCS, Rotterdam CT scores and ALI, were consolidated to construct a prognosis model, and along with GCS and Rotterdam CT scores, to configure an ALI model. Both models were visually represented by the monogram, and were operated efficiently in the assessment of various statistical metrics. Moreover, ALI partially mediated association of serum galectin3 levels with poor prognosis., Elevated serum galectin3 levels after sTBI may be significantly pertinent to trauma intensity, ALI and poor prognosis, and its association with poor prognosis may be in part mediated by ALI, substantializing serum galectin3 as an encouraging prognostic predictor of sTBI.
ISSN	0009-8981
EISSN	1873-3492
DOI	10.1016/j.cca.2025.120189
收录类别	PUBMED
URL	查看原文
PubMed ID	39938626
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/225895
专题	温州医科大学
作者单位	1.Department of Neurosurgery, Hangzhou Ninth People's Hospital, 98 Yilong Road, Hangzhou 311225, China. Electronic address: zhanglixinzyh@163.com.; 2.Outpatient Department, The Second People's Hospital of Yuhang District, 80 Anle Road, Hangzhou 311121, China. Electronic address: zhangyuhanzlx@163.com.; 3.Department of Neurosurgery, Hangzhou Ninth People's Hospital, 98 Yilong Road, Hangzhou 311225, China. Electronic address: zxl911@163.com.; 4.Department of Neurosurgery, Hangzhou Ninth People's Hospital, 98 Yilong Road, Hangzhou 311225, China. Electronic address: sunjun6666wz@163.com.; 5.Department of Neurosurgery, Hangzhou Ninth People's Hospital, 98 Yilong Road, Hangzhou 311225, China. Electronic address: Wz497lc@126.com.; 6.Department of Neurosurgery, Hangzhou Ninth People's Hospital, 98 Yilong Road, Hangzhou 311225, China. Electronic address: dxqhyy@163.com.; 7.Department of Neurosurgery, The Sixth Affiliated Hospital of Wenzhou Medical University, 15 Dazhong Road, Lishui 323000, China. Electronic address: ljljcz2024@163.com.; 8.Department of Neurosurgery, The Sixth Affiliated Hospital of Wenzhou Medical University, 15 Dazhong Road, Lishui 323000, China. Electronic address: tdtdchina@163.com.; 9.Department of Neurosurgery, The Sixth Affiliated Hospital of Wenzhou Medical University, 15 Dazhong Road, Lishui 323000, China. Electronic address: wuxiaoy123456@163.com.; 10.Department of Neurosurgery, Hangzhou Ninth People's Hospital, 98 Yilong Road, Hangzhou 311225, China. Electronic address: zhanglx197908@126.com.
推荐引用方式 GB/T 7714	Huayong Hong,Dongmin Cai,Xiaole Zhang,et al. Association of serum galectin3 levels with six-month functional outcome of severe traumatic brain injury and the mediation effect of acute lung injury: A two-center prospective cohort study[J]. Clinica chimica acta; international journal of clinical chemistry,2025.
APA	Huayong Hong., Dongmin Cai., Xiaole Zhang., Xiaofeng Wang., Qin Xie., ... & Lixin Zhang. (2025). Association of serum galectin3 levels with six-month functional outcome of severe traumatic brain injury and the mediation effect of acute lung injury: A two-center prospective cohort study. Clinica chimica acta; international journal of clinical chemistry.
MLA	Huayong Hong,et al."Association of serum galectin3 levels with six-month functional outcome of severe traumatic brain injury and the mediation effect of acute lung injury: A two-center prospective cohort study".Clinica chimica acta; international journal of clinical chemistry (2025).