Actichinone, a new ursane triterpenoid from Actinidia chinensis roots, ameliorates NAFLD via the AMPK and NF-κB pathways

doi:10.1016/j.ejphar.2025.177276

科研成果详情

题名	Actichinone, a new ursane triterpenoid from Actinidia chinensis roots, ameliorates NAFLD via the AMPK and NF-κB pathways
作者	Li, Xinhua1; Zhang, Yuanlong1; Chen, Leiqing1; Xu, Xiao 1; Ma, Xiaohong1; Lou, Shuying1; Zou, Ziqiang1; Wang, Chenjing1; Jiang, Bing1; Cai, Yunrui2; Qi, Yu1; Xi, Yiyuan 3; Zhao, Min 2; Yan, Pengcheng1
发表日期	2025-03-05
发表期刊	EUROPEAN JOURNAL OF PHARMACOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Actinidia chinensis roots Actichinone Anti-NAFLD effect AMPK NF-kappa B
其他关键词	NONALCOHOLIC FATTY LIVER ; PENTACYCLIC TRITERPENES ; ACID ; DISEASE ; OXIDATION ; INSIGHTS ; INJURY
摘要	A new ursane triterpenoid, actichinone (3-oxo-2 alpha,24-dihydroxyurs-12-en-28-oic acid, 1), was isolated from the roots of a kiwi plant Actinidia chinensis Planch, together with 18 known triterpenoids (2-19). The structure of actichinone (1) was established by extensive spectroscopic analysis. Actichinone (1) showed the most potent lipid-lowering activity in the oleic acid (OA)-induced primary mouse hepatocytes and the structure-activity relationships (SARs) were analyzed. Chemical semi-synthesis of actichinone (1) was achieved by selective oxidation of the major compound 2. Actichinone (1) exhibited significant alleviation of non-alcoholic fatty liver disease (NAFLD) in a high-fat with methionine and choline deficiency diet (HFMCD)-fed mice model, by regulating lipid accumulation and inflammatory response probably via the AMPK/SREBP-1c/PPAR-alpha and IKK/I kappa B/ NF-kappa B signaling pathways. This study provides a promising lead compound and a new insight into the development of novel anti-NAFLD agents based on the pentacyclic triterpenoid family, and is expected to promote the high value-added comprehensive application of the A. chinensis plants.
资助项目	Outstanding Youth Foundation from Wenzhou Medical University; National Natural Science Foundation of China; Wenzhou Key Laboratory of Research and Transformation of Chinese Medicine; [604091809]; [82204608]
出版者	ELSEVIER
ISSN	0014-2999
EISSN	1879-0712
卷号	990
DOI	10.1016/j.ejphar.2025.177276
页数	12
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:001407332300001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	39828019
SCOPUSEID	2-s2.0-85215415705
通讯作者地址	[Yan, Pengcheng]Wenzhou Med Univ, Sch Tradit Chinese Med, Wenzhou 325035, Zhejiang, Peoples R China. ; [Xi, Yiyuan]Wenzhou Med Univ, Clin Res Ctr, Affiliated Hosp 1, Wenzhou 325035, Zhejiang, Peoples R China.
Scopus学科分类	Pharmacology
SCOPUS_ID	SCOPUS_ID:85215415705
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/225618
专题	第二临床医学院，附属第二医院、育英儿童医院_中医系药学院（分析测试中心）第一临床医学院（信息与工程学院）、附属第一医院
通讯作者	Xi, Yiyuan; Yan, Pengcheng
作者单位	1.Wenzhou Med Univ, Sch Tradit Chinese Med, Wenzhou 325035, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Clin Res Ctr, Affiliated Hosp 1, Wenzhou 325035, Zhejiang, Peoples R China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院_中医系
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院_中医系; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院_中医系
推荐引用方式 GB/T 7714	Li, Xinhua,Zhang, Yuanlong,Chen, Leiqing,et al. Actichinone, a new ursane triterpenoid from Actinidia chinensis roots, ameliorates NAFLD via the AMPK and NF-κB pathways[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2025,990.
APA	Li, Xinhua., Zhang, Yuanlong., Chen, Leiqing., Xu, Xiao., Ma, Xiaohong., ... & Yan, Pengcheng. (2025). Actichinone, a new ursane triterpenoid from Actinidia chinensis roots, ameliorates NAFLD via the AMPK and NF-κB pathways. EUROPEAN JOURNAL OF PHARMACOLOGY, 990.
MLA	Li, Xinhua,et al."Actichinone, a new ursane triterpenoid from Actinidia chinensis roots, ameliorates NAFLD via the AMPK and NF-κB pathways".EUROPEAN JOURNAL OF PHARMACOLOGY 990(2025).