早产儿视网膜病变自然消退的影响因素

doi:10.3969/j.issn.2095-9400.2025.01.006

科研成果详情

题名	早产儿视网膜病变自然消退的影响因素
其他题名	Factors associated with spontaneous regression of retinopathy of prematurity
作者	应雅丽 1,2; 朱志敏 2; 刘丹 3; 郑穗联2,3
发表日期	2025-01-13
发表期刊	温州医科大学学报影响因子和分区
语种	中文
原始文献类型	学术期刊
关键词	早产儿视网膜病变自然消退影响因素
其他关键词	retinopathy of prematurity ; spontaneous regression ; influencing factor
摘要	目的：探索影响早产儿视网膜病变（ROP）自然消退的相关因素，为临床ROP的诊疗提供参考。方法：回顾性分析2020年5月至2022年8月温州医科大学附属第二医院育英儿童医院及台州市妇女儿童医院就诊的ROP患者，共270例270眼（较严重眼入组）。所有入组早产儿的眼睛疾病分布在ROP 1、2和3期，并且未进展为1型ROP。按自然消退的时间分为两组：1组246例在矫正胎龄50周前ROP自然消退；2组24例在矫正胎龄50周后ROP自然消退（延迟消退）。本研究共纳入19个可能的因素，采用t检验及χ2检验比较组间差异，Logistic回归分析影响ROP自然消退的影响因素。结果：1组患儿平均出生孕周为（29.5±2.5）周，平均出生体质量为（1 387.4±421.0）g,2组平均出生孕周为（28.2±2.0）周，平均出生体质量为（1 191.4±284.0）g，两组比较差异有统计学意义（P<0.05）。1组患儿的ROP III区病变及1期病变比例（分别为80.5%和60.5%）均高于2组（分别为25.0%和16.7%），差异有统计学意义（P<0.05）。与2组比，1组患儿新生儿贫血的比例更低（27.2%）、5 min Apgar评分更高（6.0）、胎盘早剥的比例更高（5.3%），差异均有统计学意义（P<0.05）。多因素Logistic回归分析显示，ROP的分期和分区、贫血、5 min Apgar评分与ROP的延迟消退相关（P<0.05）。结论：没有进展为I型的1～3期ROP均有可能在无任何治疗的情况下自然消退；ROP分期和分区、新生儿贫血、5 min Apgar评分与ROP的延迟消退有关。
其他摘要	Objective:To explore the factors associated with spontaneous regression of retinopathy of prematurity(ROP)so as to provide reference for its clinical diagnosis and treatment.Methods:A retrospective analysis was made of 270 eyes(the more severe eye)of 270 infants admitted to the Second Affiliated Hospital&Yuing Children's Hospital of Wenzhou Medical University and Taizhou Women and Children's Hospital between May 2020 and August 2022,which occurred without progressing to type 1 ROP in eyes with stages 1,2 and stage 3.They were divided into two groups by the regression pattern:Group 1 included 246 infants whose ROP spontaneous regression before the postmenstrual age of 50,and Group 2 had 24 infants whose ROP spontaneous regression over the postmenstrual age of 50(delayed involution).A total of 19 possible factors were included in the t test and chi-square test to compare the differences between groups and Logistic regression analyses was used to assess the relationship between each influencing factor and its involution pattern.Results:Mean birth weight was(1 387.4±421.0)g in Group 1 and(1 191.4±284.0)g in Group 2.Mean gestational age was(29.5±2.5)weeks in group 1 and(28.2±2.0)weeks in Group 2.T-test(chi-square test)and monofactor analysis showed that there were significant differences in birth weight,gestational age,ROP zone,ROP stage,anemia and 5-minute Apgar score between the two groups.Logistic regression analysis showed that the stage and zone of ROP,anemia,and 5-minute Apgar score were associated with delayed regression of ROP(P＜0.05).Conclusion:ROP Stage 1 to 3 without progressing to type Ⅰ may regress spontaneously without any treatment.The ROP stage,ROP zone,anemia and 5-minute Apgar score were predictive factors for delayed involution of ROP.
ISSN	2095-9400
卷号	55 期号:01 页码:36-40
DOI	10.3969/j.issn.2095-9400.2025.01.006
页数	5
收录类别	维普 ; CNKI ; 万方 ; 中国科技核心期刊
URL	查看原文
CNKI分类号	R774.1 ; R722.6
万方分类号	R77(眼科学)
维普分类号	R77
CN号	33-1386/R
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/225333
专题	附属第二医院
通讯作者	郑穗联
作者单位	1.浙江中医药大学研究生院; 2.台州市妇女儿童医院眼科; 3.温州医科大学附属第二医院育英儿童医院眼科
推荐引用方式 GB/T 7714	应雅丽,朱志敏,刘丹,等. 早产儿视网膜病变自然消退的影响因素[J]. 温州医科大学学报,2025,55(01):36-40.
APA	应雅丽, 朱志敏, 刘丹, & 郑穗联. (2025). 早产儿视网膜病变自然消退的影响因素. 温州医科大学学报, 55(01), 36-40.
MLA	应雅丽,et al."早产儿视网膜病变自然消退的影响因素".温州医科大学学报 55.01(2025):36-40.