Comparison of the effect of multidrug and single-drug adjuvant chemotherapy on the 5-year survival outcome of high-risk stage II colon cancer

doi:10.4103/ijc.ijc_267_24

科研成果详情

题名	Comparison of the effect of multidrug and single-drug adjuvant chemotherapy on the 5-year survival outcome of high-risk stage II colon cancer
作者	Song, Dandan; Chen, Minyuan; Meng, Ziqi; Zhu, Limei; Liu, Jieyu
发表日期	2024-09
发表期刊	INDIAN JOURNAL OF CANCER 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Adjuvant chemotherapy oxaliplatin survival outcome tumor marker
摘要	Background: To explore the effect of multidrug and single-drug adjuvant chemotherapy on the 5-year survival outcome of high-risk stage II colon cancer. Methods: Retrospective analysis was conducted on the clinical data of 103 high-risk stage II colon cancer patients admitted to our hospital from June 2016 to December 2017. The data was recorded using different drug adjuvant chemotherapy methods, and the subjects were divided into a multidrug group (n = 52) and a single-drug group (n = 51). The general data of the two groups, including gender, age, tumor location, clinical T stage, and metastatic site, were collected. The propensity score matching method was used to balance the baseline data between the two groups, and the confounding factors were balanced in the two groups. After matching, 29 cases were selected from each group. Follow-up for 5 years, t-test, Chi-square test, and analysis of variance were used to compare the 5-year survival outcome, tumor marker level, quality of life, adjuvant chemotherapy effect, and adverse reaction occurrence of the two groups after matching. Results: The 5-year survival rate of the single-drug group was significantly lower than that of the multidrug group (51.72% versus 79.31%), and the difference was statistically significant (P < 0.05). There was no difference in the levels of cyclooxygenase-2 (COX-2), B-lymphocyte tumor-2 gene (Bcl-2), carbohydrate antigen 125 (CA125), and quality of life score before chemotherapy between the two groups (P > 0.05). After chemotherapy, the levels of tumor markers in both groups decreased, and the level of tumor markers in the multidrug group was significantly lower than that of the single-drug group (P < 0.05). The quality of life score in the multidrug group was higher than that in the single-drug group after chemotherapy, and the difference was statistically significant (P < 0.05). After adjuvant chemotherapy, there was no significant difference in the overall response rate between the multidrug group and the single-drug group (37.93% versus 51.72%), but the disease control rate in the multidrug chemotherapy group was higher than that in the single-drug chemotherapy group (86.21% versus 62.07%). The incidence of adverse reactions in the multidrug group was not significantly different from that in the single-drug group (17.24% versus 24.14%). Conclusion: Compared with single-drug adjuvant chemotherapy, patients treated with multidrug adjuvant chemotherapy have better 5-year survival outcomes, lower levels of tumor markers in the body, better adverse reaction occurrence, and overall better efficacy of adjuvant chemotherapy than the single-drug group. The quality of life of patients has been significantly improved, and it is recommended for widespread application.
出版者	WOLTERS KLUWER MEDKNOW PUBLICATIONS
ISSN	0019-509X
EISSN	1998-4774
卷号	61 期号:3 页码:662-668
DOI	10.4103/ijc.ijc_267_24
页数	7
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:001391122100037
收录类别	SCIE
通讯作者地址	[Chen, Minyuan]Wenzhou Med Univ, Affiliated Hosp 2, Wenzhou, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/224973
专题	附属第二医院
通讯作者	Chen, Minyuan
作者单位	Wenzhou Med Univ, Affiliated Hosp 2, Wenzhou, Peoples R China
第一作者单位	附属第二医院
通讯作者单位	附属第二医院
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Song, Dandan,Chen, Minyuan,Meng, Ziqi,et al. Comparison of the effect of multidrug and single-drug adjuvant chemotherapy on the 5-year survival outcome of high-risk stage II colon cancer[J]. INDIAN JOURNAL OF CANCER,2024,61(3):662-668.
APA	Song, Dandan, Chen, Minyuan, Meng, Ziqi, Zhu, Limei, & Liu, Jieyu. (2024). Comparison of the effect of multidrug and single-drug adjuvant chemotherapy on the 5-year survival outcome of high-risk stage II colon cancer. INDIAN JOURNAL OF CANCER, 61(3), 662-668.
MLA	Song, Dandan,et al."Comparison of the effect of multidrug and single-drug adjuvant chemotherapy on the 5-year survival outcome of high-risk stage II colon cancer".INDIAN JOURNAL OF CANCER 61.3(2024):662-668.