Implication of serum soluble IL-2 receptor α in type 2 diabetes mellitus

doi:10.1007/s40200-024-01536-x

科研成果详情

题名	Implication of serum soluble IL-2 receptor α in type 2 diabetes mellitus
作者	Zhao, Bing1; Zhang, Miaomiao1; Liao, Shaoguang2,4; Jiang, Tingwang 3; Li, Jie1; Yang, Zaixing1
发表日期	2024-12-20
发表期刊	JOURNAL OF DIABETES AND METABOLIC DISORDERS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Type 2 diabetes mellitus Diabetic kidney disease IL-2 receptor
其他关键词	KIDNEY-DISEASE ; DIAGNOSIS ; INTERLEUKIN-2-RECEPTOR ; ADIPOGENESIS ; PROGRESSION ; GAMMA ; CELLS
摘要	ObjectivesThe aim of this study was to determine the association of serum soluble IL-2 receptor alpha (sIL-2RA) with T2DM-related characteristics and complications. MethodsSerum sIL-2RA levels were determined in 156 T2DM patients, and the association with T2DM-related characteristics and complications was evaluated. ResultsSerum sIL-2RA levels were significantly increased in T2DM patients with diabetic kidney disease (DKD) (median, IQR, 1434.9, 958.1-1896.0, pg/ml), in comparison with those without DKD (median, IQR, 851.2, 660.2-1089.9, pg/ml)(P < 0.001). The ROC analysis revealed good performance of sIL-2RA for identifying DKD, with the areas under the curve of 0.789 (95%CI of 0.711-0.867, P < 0.001). The correlation analyses showed significantly positive correlations of serum sIL-2RA with urea (r = 0.458, P < 0.001), creatinine (r = 0.508, P < 0.001) and uACR (r = 0.469, P < 0.001), and negative correlation with eGFR (r=-0.561, P < 0.001). The multivariate analyses showed that serum sIL-2RA was independently associated with the increased risks of DKD (OR, 95%CI, 6.539, 1.401-30.529, P = 0.017) and DR (OR, 95%CI, 3.606, 1.073-12.114, P = 0.038). Additionally, serum sIL-2RA was significantly associated with inflammatory indicators in DKD patients, and with metablic indicators in non-DKD patients (all P < 0.05). ConclusionSerum sIL-2RA may be closely associated with inflammation, glucose and lipid metabolisms, DKD and DR risks in T2DM. Furthermore, it may be a potential biomarker for T2DM-related micro-vascular complications.
资助项目	Medical Health Science and Technology Project of Zhejiang Provincial Health Commission [2024KY532]; Taizhou Science and Technology Project [22ywa31]
出版者	SPRINGER INT PUBL AG
ISSN	2251-6581
EISSN	2251-6581
卷号	24 期号:1
DOI	10.1007/s40200-024-01536-x
页数	10
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:001381132600006
收录类别	ESCI ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	39712341
SCOPUSEID	2-s2.0-85212697468
通讯作者地址	[Li, Jie;Yang, Zaixing]Wenzhou Med Univ, Taizhou Peoples Hosp 1, Huangyan Hosp, Dept Lab Med, Taizhou, Peoples R China.
Scopus学科分类	Internal Medicine;Endocrinology, Diabetes and Metabolism
SCOPUS_ID	SCOPUS_ID:85212697468
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/224880
专题	其他_附属黄岩医院（台州市第一人民医院）
通讯作者	Li, Jie; Yang, Zaixing
作者单位	1.Wenzhou Med Univ, Taizhou Peoples Hosp 1, Huangyan Hosp, Dept Lab Med, Taizhou, Peoples R China; 2.Fujian Med Univ, Mengchao Hepatobiliary Hosp, Dept Radiat Oncol, Fuzhou, Peoples R China; 3.Xuzhou Med Univ, Peoples Hosp Changshu 2, Dept Sci & Technol, Key Lab,Affiliated Changshu Hosp, Changshu, Jiangshu, Peoples R China; 4.Wenzhou Med Univ, Taizhou Peoples Hosp 1, Dept Oncol, Huangyan Hosp, Taizhou, Peoples R China
第一作者单位	其他_附属黄岩医院（台州市第一人民医院）
通讯作者单位	其他_附属黄岩医院（台州市第一人民医院）
第一作者的第一单位	其他_附属黄岩医院（台州市第一人民医院）
推荐引用方式 GB/T 7714	Zhao, Bing,Zhang, Miaomiao,Liao, Shaoguang,et al. Implication of serum soluble IL-2 receptor α in type 2 diabetes mellitus[J]. JOURNAL OF DIABETES AND METABOLIC DISORDERS,2024,24(1).
APA	Zhao, Bing, Zhang, Miaomiao, Liao, Shaoguang, Jiang, Tingwang, Li, Jie, & Yang, Zaixing. (2024). Implication of serum soluble IL-2 receptor α in type 2 diabetes mellitus. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 24(1).
MLA	Zhao, Bing,et al."Implication of serum soluble IL-2 receptor α in type 2 diabetes mellitus".JOURNAL OF DIABETES AND METABOLIC DISORDERS 24.1(2024).