Hyperbaric Oxygen Improves Cognitive Impairment Induced by Hypoxia via Upregulating the Expression of Oleic Acid and MBOAT2 of Mice

doi:10.3390/antiox13111320

科研成果详情

题名	Hyperbaric Oxygen Improves Cognitive Impairment Induced by Hypoxia via Upregulating the Expression of Oleic Acid and MBOAT2 of Mice
作者	Li, Zhen 1,2; Fu, Jun 1,3; Jiang, Kaiyuan 1; Gao, Jie 1; Guo, Yuejun1; Li, Chen 1; Zhao, Liangcai1; Nam, Jutaek 2; Gao, Hongchang1,3
发表日期	2024-11
发表期刊	ANTIOXIDANTS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	hyperbaric oxygen cognitive impairment ferroptosis membrane phospholipid remodeling MBOAT2 oleic acid
其他关键词	ISCHEMIC BRAIN-DAMAGE ; NEONATAL-RATS ; FERROPTOSIS ; THERAPY ; CELLS ; ENCEPHALOPATHY ; PROLIFERATION ; DYSFUNCTION ; ACTIVATION ; SURVIVORS
摘要	Cognitive impairment (CI) causes severe impairment of brain function and quality of life of patients, which brings a great burden to society. Cerebral hypoxia is an important factor in the pathogenesis of CI. Hyperbaric oxygen (HBO) therapy may mitigate hypoxia-induced CI, but its efficacy and mechanisms are not fully understood. In this study, a mice model of CI induced by hypoxia environment was established, then behavioral tests, pathological examination, metabolomic and lipidomic analyses, and molecular biology were used to assess the impact of HBO on hypoxia-induced CI. HBO was found to alleviate CI and pathological damage of hypoxia mice. Metabolomic, lipidomic, and molecular biology analyses showed that HBO increased the levels of oleic acid (OA) and membrane-bound O-acyltransferase 2 (MBOAT2), thereby altering the composition of membrane phospholipids (PLs) and reducing hypoxia-induced neuronal ferroptosis (FPT) to interfere with cognitive function in mice. In vitro experiments confirmed that OA and MBOAT2 led to membrane PL remodeling in a mutually dependent manner, affecting cell resistance to hypoxia-FPT. The results emphasized the combined effect value of OA and MBOAT2 in HBO for hypoxia-induced CI, and provided a novel perspective for the treatment of CI by HBO.
资助项目	National Natural Science Foundation of China; [22274115]
出版者	MDPI
ISSN	2076-3921
EISSN	2076-3921
卷号	13 期号:11
DOI	10.3390/antiox13111320
页数	17
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Food Science & Technology
收录类别	SCIE ; SCOPUS
URL	查看原文
PubMed ID	39594462
SCOPUSEID	2-s2.0-85210449612
通讯作者地址	[Gao, Hongchang]Wenzhou Med Univ, Inst Metabon & Med NMR, Sch Pharmaceut Sci, Oujiang Lab,Zhejiang Lab Regenerat Med Vis & Brain, Wenzhou 325035, Peoples R China. ; [Nam, Jutaek]Chonnam Natl Univ, Coll Pharm, Gwangju 61186, South Korea. ; [Gao, Hongchang]Wenzhou Med Univ, Innocat Acad Testing Technol, Res & Expt Ctr, Wenzhou 325035, Peoples R China.
Scopus学科分类	Food Science;Physiology;Biochemistry;Molecular Biology;Clinical Biochemistry;Cell Biology
SCOPUS_ID	SCOPUS_ID:85210449612
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/223403
专题	附属第二医院_核磁共振室
通讯作者	Nam, Jutaek; Gao, Hongchang
作者单位	1.Wenzhou Med Univ, Inst Metabon & Med NMR, Sch Pharmaceut Sci, Oujiang Lab,Zhejiang Lab Regenerat Med Vis & Brain, Wenzhou 325035, Peoples R China; 2.Chonnam Natl Univ, Coll Pharm, Gwangju 61186, South Korea; 3.Wenzhou Med Univ, Innocat Acad Testing Technol, Res & Expt Ctr, Wenzhou 325035, Peoples R China
第一作者单位	附属第二医院_核磁共振室
通讯作者单位	附属第二医院_核磁共振室; 温州医科大学
第一作者的第一单位	附属第二医院_核磁共振室
推荐引用方式 GB/T 7714	Li, Zhen,Fu, Jun,Jiang, Kaiyuan,et al. Hyperbaric Oxygen Improves Cognitive Impairment Induced by Hypoxia via Upregulating the Expression of Oleic Acid and MBOAT2 of Mice[J]. ANTIOXIDANTS,2024,13(11).
APA	Li, Zhen., Fu, Jun., Jiang, Kaiyuan., Gao, Jie., Guo, Yuejun., ... & Gao, Hongchang. (2024). Hyperbaric Oxygen Improves Cognitive Impairment Induced by Hypoxia via Upregulating the Expression of Oleic Acid and MBOAT2 of Mice. ANTIOXIDANTS, 13(11).
MLA	Li, Zhen,et al."Hyperbaric Oxygen Improves Cognitive Impairment Induced by Hypoxia via Upregulating the Expression of Oleic Acid and MBOAT2 of Mice".ANTIOXIDANTS 13.11(2024).