The association between serum ferritin levels and post-stroke depression

doi:10.1016/j.jad.2015.09.074

科研成果详情

题名	The association between serum ferritin levels and post-stroke depression
作者	Zhu, Lin 1; Han, Bin 1; Wang, Liping 1; Chang, Yaling1; Ren, Wenwei 1; Gu, Yingying1; Yan, Mengjiao 1; Wu, Chaowen 1; Zhang, Xiang Yang 2; He, Jincai1,3
发表日期	2016-01-15
发表期刊	JOURNAL OF AFFECTIVE DISORDERS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Depression Stroke Ferritin
其他关键词	BODY IRON STORES ; OXIDATIVE STRESS ; ISCHEMIC-STROKE ; RISK-FACTORS ; MECHANISMS ; DISORDERS ; SYMPTOMS
摘要	Background: Post-stroke depression (PSD) is a common neuropsychiatric affective disorder occurring after stroke. Elevated serum ferritin levels have been reported to contribute to depression. Our aim was to determine whether there is a relationship between serum ferritin levels and PSD. Methods: 196 ischemic stroke patients were consecutively recruited within the first 24 h of stroke onset and were followed up for 2 months. Serum ferritin levels were assayed by electrochemiluminescence immunoassay at hospital admission. Clinical depression was diagnosed according to DSM-IV criteria and a HAMD -17 score of >= 7. Meanwhile, 100 normal control subjects were also recruited. Results: We found that 56 stroke patients (28.6%) were diagnosed with PSD at two months. There was a significant intergroup difference in serum ferritin levels within 24 h after admission (F=25.044, P<0.001). Serum ferritin levels were significantly higher at admission in PSD patients than in non-PSD patients and normal controls. There was a positive correlation between serum ferritin levels and hs-CRP at admission in PSD patients (r=0.129, P=0.042). In multivariate analyses, serum levels of ferritin >= 130.15 mu g/L were independently associated with PSD at two months [odds ratio OR=5.388, 95% CI:1.725-16.829; P=0.004] after adjusting for all possible variables. Limitations: We excluded patients with severe aphasia and with serious conditions. In addition, the information for dietary intake was not recorded, which may influence body iron stores. Conclusion: Our findings show that elevated serum ferritin levels at admission are associated with PSD and may predict its development at 2 months post-stroke. (C) 2015 Elsevier B.V. All rights reserved.
资助项目	National Key Technology R&D Program in the 11th Five year Plan of ChinaNational Key Technology R&D Program [2009BAI77B06]; Wenzhou Municipal Sci-Tech Bureau Program [H20100021]
出版者	ELSEVIER
出版地	AMSTERDAM
ISSN	0165-0327
EISSN	1573-2517
卷号	190 页码:98-102
DOI	10.1016/j.jad.2015.09.074
页数	5
WOS类目	Clinical Neurology ; Psychiatry
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS记录号	WOS:000366463000015
收录类别	SCIE ; SSCI ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	26496014
SCOPUSEID	2-s2.0-84945288164
社科自定义期刊分类	C类
通讯作者地址	[He, Jincai]Department of Neurology, First Affiliated Hospital, Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Clinical Psychology;Psychiatry and Mental Health
TOP期刊	TOP期刊
引用统计	被引频次：22[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2219
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科附属第一医院精神医学学院_心理学系
通讯作者	He, Jincai
作者单位	1.Department of Neurology, First Affiliated Hospital, Wenzhou Medical University,Wenzhou,325000,China; 2.Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine,Houston,United States; 3.Department of Psychology, Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhu, Lin,Han, Bin,Wang, Liping,et al. The association between serum ferritin levels and post-stroke depression[J]. JOURNAL OF AFFECTIVE DISORDERS,2016,190:98-102.
APA	Zhu, Lin., Han, Bin., Wang, Liping., Chang, Yaling., Ren, Wenwei., ... & He, Jincai. (2016). The association between serum ferritin levels and post-stroke depression. JOURNAL OF AFFECTIVE DISORDERS, 190, 98-102.
MLA	Zhu, Lin,et al."The association between serum ferritin levels and post-stroke depression".JOURNAL OF AFFECTIVE DISORDERS 190(2016):98-102.