Deubiquitinase USP25 Alleviates Obesity-Induced Cardiac Remodeling and Dysfunction by Downregulating TAK1 and Reducing TAK1-Mediated Inflammation

doi:10.1016/j.jacbts.2024.06.001

科研成果详情

题名	Deubiquitinase USP25 Alleviates Obesity-Induced Cardiac Remodeling and Dysfunction by Downregulating TAK1 and Reducing TAK1-Mediated Inflammation
作者	Ye, Bozhi1,2; Chen, Yanghao1,2; Chen, Xudong 1,3; Xu, Diyun 1,2; Jiang, Yucheng2; Lin, Wante 1; Fang, Danhong1,4; Xu, Jiachen1; Han, Jibo2; Han, Xue2,5; Long, Xiaohong 2; Wang, Wei 6; Zhou, Hao 1; Wu, Gaojun1; Liang, Guang1,2,5
发表日期	2024-11-01
发表期刊	JACC: Basic to Translational Science 影响因子和分区
语种	英语
原始文献类型	Article
关键词	deubiquitinating enzyme inflammation obesity cardiomyopathy TAK1 USP25
其他关键词	CARDIOMYOPATHY ; PATHOGENESIS ; HYPERTROPHY ; CONTRIBUTES ; INHIBITION ; INJURY
摘要	Deubiquitinating enzymes play a vital role in cardiovascular diseases. This study found that cardiomyocyte ubiquitin-specific protease 25 (USP25) expression was downregulated both in myocardial tissue of obesity cardiomyopathy and palmitic acid–stimulated cardiomyocytes. USP25 deficiency exacerbated high-fat diet–induced ventricular remodeling in mice, whereas overexpression of USP25 in cardiomyocytes reversed this pathological phenotype. Mechanistically, USP25 directly binds to TAK1 and P62, and the 178-cysteine of USP25 removes the K63 ubiquitin chain from P62, which promotes the degradation of TAK1 through the autophagy-lysosome pathway, thereby ameliorating obesity-induced ventricular remodeling by reducing inflammation through the TAK1-MAPK pathway. This finding identifies USP25 as a potential therapeutic target for obesity cardiomyopathy.
资助项目	National Natural Science Foundation of China [81930108, 82271347]; Natural Science Foundation of Zhejiang Province [LTGY23H090001]; Medical Health Science and Technology Project of Zhejiang Provincial [2021KY1072]; Ningbo Natural Science Foundation [2023J 205]
出版者	ELSEVIER SCIENCE INC
ISSN	2452-302X
卷号	9 期号:11 页码:1287-1304
DOI	10.1016/j.jacbts.2024.06.001
页数	18
WOS类目	Cardiac & Cardiovascular Systems
WOS研究方向	Cardiovascular System & Cardiology
WOS记录号	WOS:001367828800001
收录类别	SCOPUS ; SCIE ; PUBMED
URL	查看原文
PubMed ID	3961914
SCOPUSEID	2-s2.0-85202012980
通讯作者地址	[Wu, Gaojun]Department of Cardiology and the Key Laboratory of Cardiovascular Disease of Wenzhou,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Cardiology and Cardiovascular Medicine
SCOPUS_ID	SCOPUS_ID:85202012980
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/221476
专题	第一临床医学院（信息与工程学院）、附属第一医院药学院（分析测试中心）附属第一医院
通讯作者	Wu, Gaojun; Liang, Guang
作者单位	1.Department of Cardiology and the Key Laboratory of Cardiovascular Disease of Wenzhou,the First Affiliated Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.Chemical Biology Research Center,School of Pharmaceutical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,China; 3.Department of Cardiology,Ningbo Hangzhou Bay Hospital,Zhejiang,Ningbo,China; 4.Department of Cardiology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Zhejiang,Hangzhou,China; 5.School of Pharmaceutical Sciences,Hangzhou Medical College,Zhejiang,Hangzhou,China; 6.Affiliated Yongkang First People's Hospital and School of Pharmacy,Hangzhou Medical College,Zhejiang,Hangzhou,China
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院; 附属第一医院; 药学院（分析测试中心）
通讯作者单位	附属第一医院
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院; 附属第一医院
推荐引用方式 GB/T 7714	Ye, Bozhi,Chen, Yanghao,Chen, Xudong,et al. Deubiquitinase USP25 Alleviates Obesity-Induced Cardiac Remodeling and Dysfunction by Downregulating TAK1 and Reducing TAK1-Mediated Inflammation[J]. JACC: Basic to Translational Science,2024,9(11):1287-1304.
APA	Ye, Bozhi., Chen, Yanghao., Chen, Xudong., Xu, Diyun., Jiang, Yucheng., ... & Liang, Guang. (2024). Deubiquitinase USP25 Alleviates Obesity-Induced Cardiac Remodeling and Dysfunction by Downregulating TAK1 and Reducing TAK1-Mediated Inflammation. JACC: Basic to Translational Science, 9(11), 1287-1304.
MLA	Ye, Bozhi,et al."Deubiquitinase USP25 Alleviates Obesity-Induced Cardiac Remodeling and Dysfunction by Downregulating TAK1 and Reducing TAK1-Mediated Inflammation".JACC: Basic to Translational Science 9.11(2024):1287-1304.