题名 | Micheliolide ameliorates severe acute pancreatitis in mice through potentiating Nrf2-mediated anti-inflammation and anti-oxidation effects |
作者 | |
发表日期 | 2024-12-25 |
发表期刊 | INTERNATIONAL IMMUNOPHARMACOLOGY 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | Micheliolide Severe acute pancreatitis Nuclear factor erythroid 2-related factor 2 Nuclear factor kappa B p65 |
其他关键词 | NF-KAPPA-B ; OXIDATIVE STRESS ; PATHOGENESIS ; AUTOPHAGY |
摘要 | Severe acute pancreatitis (SAP) is an acute inflammatory injury disease with significant mortality rate and currently without effective strategy being available. Inflammation and oxidative stress play central roles in the etiology of SAP. Micheliolide (MCL), an active monomeric component isolated from Michelia champaca, has been proved its multiple therapeutic properties including anti-inflammatory, antioxidant and anti-cancer. Nevertheless, the therapeutic effect and underlying mechanism of MCL in SAP still remain unclear. Here, we found that caerulein with lipopolysaccharide (LPS)-induced SAP murine models exhibited severe pancreatic injury, including necrosis, edema, and vacuolation of acinar cells in the pancreas, elevated serum levels of amylase and lipase, and reduced number of the exocrine cells. As expected, MCL treatment alleviated these side effects. Mechanistically, MCL triggered nuclear factor erythroid 2-related factor 2 (Nrf2) activation, thereby activating Nrf2-regulated antioxidative pathways and inhibiting nuclear factor kappa B p65 (NF-kappa B p65)-mediated inflammatory response, resulting in protection against pancreatic injury in SAP mice. In addition, Nrf2 gene deficiency abolished the beneficial effects of MCL on SAP-induced pancreatic inflammation and oxidative stress and blocked the ability of MCL to alleviate the pancreatic injury in SAP mice. Collectively, these findings indicated that the suppression of SAP-induced pancreatic injury by MCL was at least in part due to Nrf2-mediated anti-oxidation effect and inhibition of inflammation. |
资助项目 | Wenzhou Science and Technology bureau [Y2020231]; Natural Science Foundation of Zhe-jiang province [LQ23H050001, ZCLQ24H0303]; National Nat-ural Sciences Foundation of China [82070834] |
出版者 | ELSEVIER |
ISSN | 1567-5769 |
EISSN | 1878-1705 |
卷号 | 143期号:Pt 2 |
DOI | 10.1016/j.intimp.2024.113490 |
页数 | 13 |
WOS类目 | Immunology ; Pharmacology & Pharmacy |
WOS研究方向 | Immunology ; Pharmacology & Pharmacy |
WOS记录号 | WOS:001347351000001 |
收录类别 | SCIE ; SCOPUS ; PUBMED |
URL | 查看原文 |
PubMed ID | 39467351 |
SCOPUSEID | 2-s2.0-85207170320 |
通讯作者地址 | [Lu, Chao-Sheng;Hu, Qing-Qing]Wenzhou Med Univ, Affiliated Hosp 1, Dept Pediat, 322 Nanbaixiang St, Wenzhou 325000, Zhejiang, Peoples R China. |
Scopus学科分类 | Immunology and Allergy;Immunology;Pharmacology |
SCOPUS_ID | SCOPUS_ID:85207170320 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/221443 |
专题 | 附属第一医院_儿科 第一临床医学院(信息与工程学院)、附属第一医院 附属第一医院 第一临床医学院(信息与工程学院)、附属第一医院_外科学_甲状腺外科 |
通讯作者 | Lu, Chao-Sheng; Hu, Qing-Qing |
作者单位 | 1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Pediat, 322 Nanbaixiang St, Wenzhou 325000, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Zhejiang Key Lab Intelligent Canc Biomarker Discov, Wenzhou 325000, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 1, Dept Thyroid Surg, Wenzhou 325000, Peoples R China; 4.Wenzhou Med Univ, Clin Med Coll 1, Wenzhou 325000, Peoples R China |
第一作者单位 | 附属第一医院_儿科; 附属第一医院 |
通讯作者单位 | 附属第一医院_儿科 |
第一作者的第一单位 | 附属第一医院_儿科 |
推荐引用方式 GB/T 7714 | Wu, Chen-Yu,Wang, Ke-Qi,Qin, Yu-Ying,et al. Micheliolide ameliorates severe acute pancreatitis in mice through potentiating Nrf2-mediated anti-inflammation and anti-oxidation effects[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2024,143(Pt 2). |
APA | Wu, Chen-Yu., Wang, Ke-Qi., Qin, Yu-Ying., Wang, Hong-Wei., Wu, Min-Min., ... & Hu, Qing-Qing. (2024). Micheliolide ameliorates severe acute pancreatitis in mice through potentiating Nrf2-mediated anti-inflammation and anti-oxidation effects. INTERNATIONAL IMMUNOPHARMACOLOGY, 143(Pt 2). |
MLA | Wu, Chen-Yu,et al."Micheliolide ameliorates severe acute pancreatitis in mice through potentiating Nrf2-mediated anti-inflammation and anti-oxidation effects".INTERNATIONAL IMMUNOPHARMACOLOGY 143.Pt 2(2024). |
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