Deciphering the Therapeutic Efficacy and Underlying Mechanisms of Dendrobium officinale Polysaccharides in the Intervention of Alzheimer's Disease Mice: Insights from Metabolomics and Microbiome

doi:10.1021/acs.jafc.4c07913

科研成果详情

题名	Deciphering the Therapeutic Efficacy and Underlying Mechanisms of Dendrobium officinale Polysaccharides in the Intervention of Alzheimer's Disease Mice: Insights from Metabolomics and Microbiome
作者	Fu, Jun 1,2; Liang, Zhaohan1; Chen, Zihao 1; Zhou, Yiyang 1; Xiong, Fen 1; Liang, Qian1,2; Gao, Hongchang1,2,3,4
发表日期	2024-11-13
发表期刊	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Dendrobium officinalepolysaccharide metabolomics microbiome
其他关键词	GUT-MICROBIOTA ; METABOLISM ; IMPACT
摘要	As a traditional drug-food homologous plant, Dendrobium officinale is widely recognized for its nutritional and medicinal value. Specifically, D. officinale polysaccharide (DOP) has garnered attention as a potential prebiotic for its protective effects on gut microbiota and the nervous system. However, the underlying mechanism by which DOP improves cognitive dysfunction in Alzheimer's disease (AD) remains unclear. This study intends to elucidate the beneficial effects of DOP on AD mice from the perspectives of metabolomics and the intestinal microbiome. The results showed that DOP significantly ameliorated cognitive dysfunction, attenuated hippocampal neuronal damage and A beta plaque deposition, and restored intestinal barrier integrity in AD mice. The antibiotic-cocktail-induced germ-free mouse model confirmed that the neuroprotective effect of DOP was dependent on gut microbiota. Further investigations demonstrated that DOP influenced the composition of gut microbiota and restored its diversity. Additionally, DOP reshaped metabolic profile disorders in AD mice and increased the short-chain fatty acids (SCFAs) content. Correlation analysis further highlighted that specific gut microbiota was associated with the metabolism of AD mice. In conclusion, this study sheds light on the positive impact of DOP in reshaping the gut microbiota and enhancing cognitive function, offering important perspectives for the possible advancement and utilization of DOP.
资助项目	National Natural Science Foundation of China [22274115]; National Natural Science Foundation of China
出版者	AMER CHEMICAL SOC
ISSN	0021-8561
EISSN	1520-5118
DOI	10.1021/acs.jafc.4c07913
页数	14
WOS类目	Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
WOS记录号	WOS:001353950300001
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	39536176
通讯作者地址	[Gao, Hongchang]Wenzhou Med Univ, Innovat Acad Testing Technol, Sci Res Ctr, Wenzhou 325035, Peoples R China. ; [Gao, Hongchang]Wenzhou Med Univ, Key Lab Efficacy Evaluat Tradit Chinese Med & Ence, Wenzhou 325035, Peoples R China. ; [Gao, Hongchang]Wenzhou Med Univ, Sch Pharmaceut Sci, Oujiang Lab, Zhejiang Lab Regenerat Med Vis & Brain Hlth, Wenzhou 325035, Peoples R China. ; [Gao, Hongchang]Wenzhou Med Univ, Inst Metabon & Med NMR, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/221389
专题	温州医科大学药学院（分析测试中心）附属第二医院_核磁共振室
通讯作者	Gao, Hongchang
作者单位	1.Wenzhou Med Univ, Innovat Acad Testing Technol, Sci Res Ctr, Wenzhou 325035, Peoples R China; 2.Wenzhou Med Univ, Key Lab Efficacy Evaluat Tradit Chinese Med & Ence, Wenzhou 325035, Peoples R China; 3.Wenzhou Med Univ, Sch Pharmaceut Sci, Oujiang Lab, Zhejiang Lab Regenerat Med Vis & Brain Hlth, Wenzhou 325035, Peoples R China; 4.Wenzhou Med Univ, Inst Metabon & Med NMR, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China
第一作者单位	温州医科大学;
通讯作者单位	温州医科大学; 药学院（分析测试中心）; 附属第二医院_核磁共振室
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Fu, Jun,Liang, Zhaohan,Chen, Zihao,et al. Deciphering the Therapeutic Efficacy and Underlying Mechanisms of Dendrobium officinale Polysaccharides in the Intervention of Alzheimer's Disease Mice: Insights from Metabolomics and Microbiome[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2024.
APA	Fu, Jun., Liang, Zhaohan., Chen, Zihao., Zhou, Yiyang., Xiong, Fen., ... & Gao, Hongchang. (2024). Deciphering the Therapeutic Efficacy and Underlying Mechanisms of Dendrobium officinale Polysaccharides in the Intervention of Alzheimer's Disease Mice: Insights from Metabolomics and Microbiome. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.
MLA	Fu, Jun,et al."Deciphering the Therapeutic Efficacy and Underlying Mechanisms of Dendrobium officinale Polysaccharides in the Intervention of Alzheimer's Disease Mice: Insights from Metabolomics and Microbiome".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2024).