The correlation between S-nitrosylation and type 2 diabetes mellitus: a review

doi:10.5603/ep.100226

科研成果详情

题名	The correlation between S-nitrosylation and type 2 diabetes mellitus: a review
作者	Li, Li 1; Hu, Fei2
发表日期	2024
发表期刊	ENDOKRYNOLOGIA POLSKA 影响因子和分区
语种	英语
原始文献类型	Review
关键词	S-nitrosylation type 2 diabetes mellitus insulin resistance glucokinase
其他关键词	NITRIC-OXIDE SYNTHASE ; PROTEIN-KINASE-B/AKT ; INSULIN-RESISTANCE ; TARGETED DISRUPTION ; NITROSATION ; GLUCOKINASE ; MECHANISM ; RECEPTOR ; RELEASE ; STRESS
摘要	Type 2 diabetes mellitus (T2DM) represents a chronic metabolic disorder, constituting over 90% of all diabetes cases. Its primary characteristics include insulin deficiency and insulin resistance. The aetiology of T2DM is complex, which is attributed to a convergence of genetic and environmental factors. Moreover, it can engender various complications such as diabetes retinopathy, diabetes nephropathy, and diabetes neuropathy. T2DM cannot be cured fundamentally, it can only delay the development of the disease by controlling the blood sugar level. If the blood sugar is at a high level for a long time, it will aggravate the disease progress, and even lead to death in serious cases. Therefore, understanding the pathogenesis of diabetes, early detection, and intervention are the main means of treatment. S-nitrosylation (SNO), a post-translational modification of proteins based on redox, possesses the capacity to regulate a variety of physiological and pathological processes, and it is also involved in the occurrence and development of T2DM. However, the relationship between the dysregulation of SNO homeostasis and the occurrence of diabetes is not fully understood. This article reviews the correlation between SNO and T2DM, elucidating the mechanism by which SNO contributes to T2DM, encompassing diminishing insulin secretion, inducing insulin resistance, and affecting glucokinase activity. Understanding the correlation between SNO and T2DM provides a new research direction for the pathogenesis and treatment targets of diabetes. (Endokrynol Pol 2024; 75 (5): 473-478)
资助项目	Natural Science Foundation of Ningbo City [2021J031]
出版者	VIA MEDICA
ISSN	0423-104X
卷号	75 期号:5 页码:473-478
DOI	10.5603/ep.100226
页数	6
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:001346488900001
收录类别	SCIE
PubMed ID	3947513
通讯作者地址	[Hu, Fei]508 North Second Ring East Rd Gutang St, Cixi, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/221379
专题	其他_温州医科大学慈溪生物医药研究院
通讯作者	Hu, Fei
作者单位	1.Lishui Municipal Cent Hosp, Dept Pharm, Lishui, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Cixi Biomed Res Inst, Cixi, Peoples R China
推荐引用方式 GB/T 7714	Li, Li,Hu, Fei. The correlation between S-nitrosylation and type 2 diabetes mellitus: a review[J]. ENDOKRYNOLOGIA POLSKA,2024,75(5):473-478.
APA	Li, Li, & Hu, Fei. (2024). The correlation between S-nitrosylation and type 2 diabetes mellitus: a review. ENDOKRYNOLOGIA POLSKA, 75(5), 473-478.
MLA	Li, Li,et al."The correlation between S-nitrosylation and type 2 diabetes mellitus: a review".ENDOKRYNOLOGIA POLSKA 75.5(2024):473-478.