Exploring the relationship of sleep duration on cognitive function among the elderly: a combined NHANES 2011-2014 and mendelian randomization analysis

doi:10.1186/s12877-024-05511-2

科研成果详情

题名	Exploring the relationship of sleep duration on cognitive function among the elderly: a combined NHANES 2011-2014 and mendelian randomization analysis
作者	Qiu, Peng 1; Dong, Cheng 2; Li, Aifen 3; Xie, Juanjuan4; Wu, Junyu 5
发表日期	2024-11-12
发表期刊	BMC GERIATRICS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Sleep duration Cognitive function NAHENS Mendelian randomization Older adults
其他关键词	ALZHEIMERS-DISEASE ; PHYSICAL-ACTIVITY ; UNITED-STATES ; INSTRUMENTS ; ADULTS ; RISK ; ASSOCIATIONS ; METAANALYSIS ; IMPAIRMENT ; HEALTH
摘要	Background As one of the key features of sleep, sleep duration (SD) has been confirmed to be associated with multiple health outcomes. However, the link between SD and cognitive function (CF) is still not well understood. Methods We employed a combined approach utilizing data from the National Health and Nutrition Examination Survey (NHANES 2011-2014) and Mendelian Randomization (MR) methods to investigate the relationship between SD and CF. In the NHANES cross-sectional analysis, the association between these variables was primarily examined through multivariate linear regression to explore direct correlations and utilized smoothing curve fitting to assess potential nonlinear relationships. To ensure the robustness of our findings, subgroup analyses were also conducted. MR analysis was used to assess the causal relationship between SD and sleeplessness on CF. After excluding confounding factors, univariate and multivariate MR were performed using inverse variance weighting (IVW) as the main analysis method, and sensitivity analysis was performed. Results The results of our cross-sectional study indicate a notable negative association between SD and CF, forming an inverted U-shaped curve with the inflection point occurring at SD = 6 h. This relationship remains consistent and robust across subgroup analyses differentiated by variables such as age, levels of physical activity, and frequency of alcohol intake. In MR analysis, IVW analysis showed no causal relationship between SD and sleeplessness on CF (Both P > 0.05). Conclusion Cross-sectional studies suggest the existence of an inverted U-shaped correlation between SD and CF among the elderly. However, MR analysis did not reveal a causal relationship between SD and CF, which the lack of nonlinear MR analysis may limit. These findings provide evidence from a sleep perspective for optimizing cognitive strategies in older adults.
出版者	BMC
ISSN	1471-2318
EISSN	1471-2318
卷号	24 期号:1
DOI	10.1186/s12877-024-05511-2
页数	13
WOS类目	Geriatrics & Gerontology ; Gerontology
WOS研究方向	Geriatrics & Gerontology
WOS记录号	WOS:001353605000003
收录类别	SCIE ; SCOPUS ; PUBMED ; SSCI
URL	查看原文
PubMed ID	39533213
SCOPUSEID	2-s2.0-85209383373
通讯作者地址	[Wu, Junyu]Shanghai Univ Sport, Sch Phys Educ, Shanghai, Peoples R China.
Scopus学科分类	Geriatrics and Gerontology
SCOPUS_ID	SCOPUS_ID:85209383373
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/221275
专题	附属第一医院_康复科附属第一医院
通讯作者	Wu, Junyu
作者单位	1.Wenzhou Med Univ, Dept Rehabil, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China; 2.Shanghai Jiao Tong Univ, Ruijin Hosp, Depart Rehabil Med, Sch Med, Shanghai, Peoples R China; 3.Kunming Assoc Sci & Technol, Dept Sci Popularizat Ctr, Kunming, Yunnan, Peoples R China; 4.Wenzhou Med Univ, Dept Cardiol, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China; 5.Shanghai Univ Sport, Sch Phys Educ, Shanghai, Peoples R China
第一作者单位	附属第一医院_康复科
第一作者的第一单位	附属第一医院_康复科
推荐引用方式 GB/T 7714	Qiu, Peng,Dong, Cheng,Li, Aifen,et al. Exploring the relationship of sleep duration on cognitive function among the elderly: a combined NHANES 2011-2014 and mendelian randomization analysis[J]. BMC GERIATRICS,2024,24(1).
APA	Qiu, Peng, Dong, Cheng, Li, Aifen, Xie, Juanjuan, & Wu, Junyu. (2024). Exploring the relationship of sleep duration on cognitive function among the elderly: a combined NHANES 2011-2014 and mendelian randomization analysis. BMC GERIATRICS, 24(1).
MLA	Qiu, Peng,et al."Exploring the relationship of sleep duration on cognitive function among the elderly: a combined NHANES 2011-2014 and mendelian randomization analysis".BMC GERIATRICS 24.1(2024).