Implantation of biomimetic polydopamine nanocomposite scaffold promotes optic nerve regeneration through modulating inhibitory microenvironment

doi:10.1186/s12951-024-02962-y

科研成果详情

题名	Implantation of biomimetic polydopamine nanocomposite scaffold promotes optic nerve regeneration through modulating inhibitory microenvironment
作者	Pan, Tonghe 1,2; Huang, Yate1,2; Wei, Jinfei1; Lai, Chen 3; Chen, Yangjun1,2; Nan, Kaihui1,2; Wu, Wencan1,4,5
发表日期	2024-11-07
发表期刊	JOURNAL OF NANOBIOTECHNOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Biomimetic scaffold Reactive oxygen species Polydopamine nanoparticles Microenvironment modulation Optic nerve regeneration
其他关键词	AXON REGENERATION ; NANOPARTICLES ; PROTECTION ; INJURY ; MODEL
摘要	Optic nerve regeneration remains challenging worldwide due to the limited intrinsic regenerative capacity of retinal ganglion cells (RGCs) and the inhibitory microenvironment. Oxidative stress, induced by excessive reactive oxygen species (ROS) following optic nerve injury, is associated with prolonged neuroinflammation, resulting in a secondary injury of RGCs and the impairment of axon regeneration. Herein, we developed a bionic nanocomposite scaffold (GA@PDA) with immunoregulatory ability for enhanced optic nerve regeneration. The ice-templating method was employed to fabricate biopolymer-based scaffolds with a directional porous structure, mimicking the optic nerve, which effectively guided the oriented growth of neuronal cells. The incorporation of bioinspired polydopamine nanoparticles (PDA NPs) further confers excellent ROS scavenging ability, thereby modulating the phenotype transformation of microglia/macrophages from pro-inflammatory M1 to anti-inflammatory M2. In a rat optic nerve crush model, the implantation of GA@PDA scaffold enhanced survival of RGCs and promoted axonal regeneration. Our study offers novel insights and holds promising potential for the advancement of engineered biomaterials in facilitating optic nerve regeneration.
资助项目	International Education Research Foundation
出版者	BMC
ISSN	1477-3155
EISSN	1477-3155
卷号	22 期号:1
DOI	10.1186/s12951-024-02962-y
页数	17
WOS类目	Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
WOS研究方向	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS记录号	WOS:001348932600002
收录类别	SCIE ; EI ; SCOPUS ; PUBMED
EI入藏号	20244617364915
EI主题词	Reactive oxygen species
EI分类号	101.1 ; 103 ; 103.2 ; 1301.4 ; 405.1 Construction Equipment ; 761 Nanotechnology ; 801.1 Chemistry, General
URL	查看原文
PubMed ID	39506841
SCOPUSEID	2-s2.0-85208689134
通讯作者地址	[Chen, Yangjun;Nan, Kaihui;Wu, Wencan]Wenzhou Med Univ, Eye Hosp, Sch Ophthalmol & Optometry, State Key Lab Ophthalmol Optometry & Vis Sci, Wenzhou 325027, Zhejiang, Peoples R China. ; [Chen, Yangjun;Nan, Kaihui]Wenzhou Med Univ, Eye Hosp, Inst Biomed Engn, Natl Engn Res Ctr Ophthalmol & Optometry, Wenzhou 325027, Zhejiang, Peoples R China. ; [Wu, Wencan]Wenzhou Med Univ, Eye Hosp, Natl Clin Res Ctr Ocular Dis, Wenzhou 325027, Zhejiang, Peoples R China. ; [Wu, Wencan]Oujiang Lab, Zhejiang Lab Regenerat Med Vis & Brain Hlth, Wenzhou 325000, Zhejiang, Peoples R China.
Scopus学科分类	Bioengineering;Medicine (miscellaneous);Molecular Medicine;Biomedical Engineering;Applied Microbiology and Biotechnology;Pharmaceutical Science
SCOPUS_ID	SCOPUS_ID:85208689134
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/221260
专题	眼视光学院（生物医学工程学院）、附属眼视光医院眼视光学院（生物医学工程学院）、附属眼视光医院_生物医学信息系
通讯作者	Chen, Yangjun; Nan, Kaihui; Wu, Wencan
作者单位	1.Wenzhou Med Univ, Eye Hosp, Sch Ophthalmol & Optometry, State Key Lab Ophthalmol Optometry & Vis Sci, Wenzhou 325027, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Eye Hosp, Inst Biomed Engn, Natl Engn Res Ctr Ophthalmol & Optometry, Wenzhou 325027, Zhejiang, Peoples R China; 3.PKU HKUST ShenZhen HongKong Inst, Shenzhen Key Lab Human Tissue Regenerat & Repair, Shenzhen 518057, Peoples R China; 4.Wenzhou Med Univ, Eye Hosp, Natl Clin Res Ctr Ocular Dis, Wenzhou 325027, Zhejiang, Peoples R China; 5.Oujiang Lab, Zhejiang Lab Regenerat Med Vis & Brain Hlth, Wenzhou 325000, Zhejiang, Peoples R China
第一作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院; 眼视光学院（生物医学工程学院）、附属眼视光医院_生物医学信息系
通讯作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院; 眼视光学院（生物医学工程学院）、附属眼视光医院_生物医学信息系
第一作者的第一单位	眼视光学院（生物医学工程学院）、附属眼视光医院
推荐引用方式 GB/T 7714	Pan, Tonghe,Huang, Yate,Wei, Jinfei,et al. Implantation of biomimetic polydopamine nanocomposite scaffold promotes optic nerve regeneration through modulating inhibitory microenvironment[J]. JOURNAL OF NANOBIOTECHNOLOGY,2024,22(1).
APA	Pan, Tonghe., Huang, Yate., Wei, Jinfei., Lai, Chen., Chen, Yangjun., ... & Wu, Wencan. (2024). Implantation of biomimetic polydopamine nanocomposite scaffold promotes optic nerve regeneration through modulating inhibitory microenvironment. JOURNAL OF NANOBIOTECHNOLOGY, 22(1).
MLA	Pan, Tonghe,et al."Implantation of biomimetic polydopamine nanocomposite scaffold promotes optic nerve regeneration through modulating inhibitory microenvironment".JOURNAL OF NANOBIOTECHNOLOGY 22.1(2024).