Dihydro-resveratrol ameliorates NLRP3 inflammasome-mediated neuroinflammation via Bnip3-dependent mitophagy in Alzheimer's disease

doi:10.1111/bph.17373

科研成果详情

题名	Dihydro-resveratrol ameliorates NLRP3 inflammasome-mediated neuroinflammation via Bnip3-dependent mitophagy in Alzheimer's disease
作者	Tao, Guorong 1,2,3,4; Wang, Xuebao5; Wang, Jian 2,3,6; Ye, Yiru2,3,7; Zhang, Minxue1,2,3; Lang, Yan1,2,3; Ding, Saidan 1,2,3
发表日期	2024-10-28
发表期刊	BRITISH JOURNAL OF PHARMACOLOGY 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Alzheimer's disease autophagy dihydro-resveratrol inflammation mitophagy
其他关键词	AUTOPHAGY ; PROTEIN ; BNIP3 ; GUIDE
摘要	Background and PurposeDihydro-resveratrol (DHR), a polyphenol derivative, that has been demonstrated to suppress inflammation-mediated injury. However, it is still unknown whether it has anti-neuroinflammatory and neuroprotective effects, and a therapeutic action in Alzheimer's disease (AD). Experimental approachThe anti-inflammatory and anti-Alzheimer's disease actions of dihydro-resveratrol were investigated using lipopolysaccharide (LPS) and AD mice models, and primary microglial cells. The changes in behaviour in mice were detected by the Morris water maze test and open-field test. Flow cytometry assay, western blotting, immunofluorescence assays and co-immunoprecipitation were used to investigate the changes in the NLRP3 inflammasome activation and mitophagy. Key ResultsIn this study, in vivo observations indicated that the administration of dihydro-resveratrol (DHR) dramatically restored spatial learning, memory ability, autophagy and mitophagy, attenuated NLRP3 inflammasome activation, neuroinflammation and amyloid precursor protein pathology in LPS mice and AD mice. In addition, the inhibition of autophagy and mitophagy, or the activation of NLRP3 in vivo greatly abolished DHR-generated therapeutic efficacy on neuroinflammation, amyloid precursor protein pathology and cognitive loss. Further examination indicated that the application of DHR after the LPS and ATP exposure significantly inhibited the NLRP3 inflammasome activation, neuroinflammation and enhanced autophagic and mitophagic activation in microglia. Additionally, in vitro results show that DHR protects microglial cells against LPS and ATP-induced cytotoxicity by inhibiting NLRP3 inflammasome through activating Bnip3-dependent mitophagy and ULK phosphorylation. Conclusions and ImplicationsIn summary, these findings suggest that dihydro-resveratrol (DHR) possesses potent anti-neuroinflammatory property and can act as a potential therapeutic agent for the treatment of AD.
资助项目	National Natural Science Foundation of China
出版者	WILEY
ISSN	0007-1188
EISSN	1476-5381
卷号	182 期号:4 页码:1005-1024
DOI	10.1111/bph.17373
页数	20
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:001347082300001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	39467709
SCOPUSEID	2-s2.0-85207949928
通讯作者地址	[Ding, Saidan]Fudan Univ, Lab Anim Ctr, Shanghai 200032, Peoples R China.
Scopus学科分类	Pharmacology
SCOPUS_ID	SCOPUS_ID:85207949928
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/221229
专题	第一临床医学院（信息与工程学院）、附属第一医院_浙江省胰脏肝脏危重性疾病重点实验室温州医科大学药学院（分析测试中心）第一临床医学院（信息与工程学院）、附属第一医院_中心实验室
通讯作者	Ding, Saidan
作者单位	1.Fudan Univ, Lab Anim Ctr, Shanghai 200032, Peoples R China; 2.Wenzhou Med Univ, Key Lab Diag & Treatment Severe Hepatopancreat Dis, Affiliated Hosp 1, Wenzhou, Peoples R China; 3.Wenzhou Med Univ, Cent Lab, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China; 4.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Anesthesiol, Shanghai, Peoples R China; 5.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou, Zhejiang, Peoples R China; 6.Hubei Polytech Univ, Huangshi Love & Hlth Hosp, Huangshi, Peoples R China; 7.Wenzhou Med Univ, Sch Informat & Engn, Wenzhou, Zhejiang, Peoples R China
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_浙江省胰脏肝脏危重性疾病重点实验室; 第一临床医学院（信息与工程学院）、附属第一医院_中心实验室
推荐引用方式 GB/T 7714	Tao, Guorong,Wang, Xuebao,Wang, Jian,et al. Dihydro-resveratrol ameliorates NLRP3 inflammasome-mediated neuroinflammation via Bnip3-dependent mitophagy in Alzheimer's disease[J]. BRITISH JOURNAL OF PHARMACOLOGY,2024,182(4):1005-1024.
APA	Tao, Guorong., Wang, Xuebao., Wang, Jian., Ye, Yiru., Zhang, Minxue., ... & Ding, Saidan. (2024). Dihydro-resveratrol ameliorates NLRP3 inflammasome-mediated neuroinflammation via Bnip3-dependent mitophagy in Alzheimer's disease. BRITISH JOURNAL OF PHARMACOLOGY, 182(4), 1005-1024.
MLA	Tao, Guorong,et al."Dihydro-resveratrol ameliorates NLRP3 inflammasome-mediated neuroinflammation via Bnip3-dependent mitophagy in Alzheimer's disease".BRITISH JOURNAL OF PHARMACOLOGY 182.4(2024):1005-1024.