Downregulation of paraoxonase 3 contributes to aggressive human hepatocellular carcinoma progression and associates with poor prognosis

doi:10.1007/s13277-016-5247-z

科研成果详情

题名	Downregulation of paraoxonase 3 contributes to aggressive human hepatocellular carcinoma progression and associates with poor prognosis
作者	Jin, Yuepeng1; Li, Qiang 2; Qiu, Junjun 3; Zhao, Xiufen1; Zheng, Chunxiao1; Lv, Shixu 3; Bai, Yongyu 2; Shan, Yunfeng1; Ye, Le-chi4
发表日期	2016-10
发表期刊	TUMOR BIOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Paraoxonase 3 Hepatocellular carcinoma Prognosis Growth Metastasis
其他关键词	GENE-EXPRESSION PROFILES ; ATHEROSCLEROSIS ; PROTECTS ; FAMILY ; PON3 ; CLASSIFICATION ; POLYMORPHISMS ; MOUSE ; RISK
摘要	Paraoxonase (PON) enzymes possess antioxidant properties and protect against cardiovascular diseases. As a member of PON family, PON3 is primarily synthesized in the liver and poorly investigated. This study aimed to examine the expression of PON3 in human hepatocellular carcinoma (HCC) and investigate the clinical significance and biological function of PON3 in HCC patients. We first analyzed PON3 expression in 50 paired HCC samples (HCC tissues vs matched para-cancerous tissues) and 160 clinical HCC specimens by using immunohistochemistry (IHC). Our results showed that the expression of PON3 was downregulated in HCC and significantly associated with tumor-node-metastasis (TNM) stage, tumor size, and tumor number. Kaplan-Meier survival and Cox regression analyses showed that PON3 was an independent prognostic factor for overall survival (OS) and time to recurrence (TTR). Finally, we aimed to reveal the biological function of PON3 in HCC growth and metastasis, and our results showed that overexpression of PON3 potently inhibited growth and metastasis of HCC. Collectively, our study demonstrated that PON3 exhibited tumor-suppressive effects toward HCC and it might serve as a novel prognostic marker in HCC.
资助项目	Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LY12H03006, LY15H160058]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81572291]
出版者	SAGE PUBLICATIONS LTD
出版地	LONDON
ISSN	1010-4283
EISSN	1423-0380
卷号	37 期号:10 页码:14193-14203
DOI	10.1007/s13277-016-5247-z
页数	11
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000387538700114
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	27553024
SCOPUSEID	2-s2.0-84983458015
通讯作者地址	[Ye, Le-chi]Department of Oncological Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Cancer Research
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2211
专题	附属第一医院附属第一医院_肿瘤外科
通讯作者	Ye, Le-chi
作者单位	1.Department of General Surgery,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China; 2.Wenzhou Medical University,Wenzhou,China; 3.Department of Gynecology,Obstetrics and Gynecology Hospital,Fudan University,Shanghai,200011,China; 4.Department of Oncological Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Jin, Yuepeng,Li, Qiang,Qiu, Junjun,et al. Downregulation of paraoxonase 3 contributes to aggressive human hepatocellular carcinoma progression and associates with poor prognosis[J]. TUMOR BIOLOGY,2016,37(10):14193-14203.
APA	Jin, Yuepeng., Li, Qiang., Qiu, Junjun., Zhao, Xiufen., Zheng, Chunxiao., ... & Ye, Le-chi. (2016). Downregulation of paraoxonase 3 contributes to aggressive human hepatocellular carcinoma progression and associates with poor prognosis. TUMOR BIOLOGY, 37(10), 14193-14203.
MLA	Jin, Yuepeng,et al."Downregulation of paraoxonase 3 contributes to aggressive human hepatocellular carcinoma progression and associates with poor prognosis".TUMOR BIOLOGY 37.10(2016):14193-14203.