Two-pronged strategy: A mitochondria targeting AIE photosensitizer for hydrogen sulfide detection and type I and type II photodynamic therapy

doi:10.1016/j.talanta.2024.127074

科研成果详情

题名	Two-pronged strategy: A mitochondria targeting AIE photosensitizer for hydrogen sulfide detection and type I and type II photodynamic therapy
作者	Shi, Jizhong 2; Liang, Manshan1,4; Qiu, Yiting1; Zhang, Jin1; Wang, Shihua1; Fang, Heng 2; Jiang, Yongsheng2; Ye, Xiaoxia1; Luo, Yanshu 3; Huang, Zu-Sheng1; Quan, Yun-Yun1
发表日期	2025
发表期刊	Talanta 影响因子和分区
语种	英语
原始文献类型	Article
关键词	AIE H2S detection Mitochondria targeting Two-pronged strategy Type I and type II PDT
摘要	Multifunctional type-I photosensitizers (PSs) for hydrogen sulfide (H2S) detection and photodynamic therapy (PDT) of hypoxia tumors exhibits attractive curative effect but remains a challenging task. Herein, a mitochondria targeted aggregation-induced emission (AIE) photosensitizer TSPy-SS-P was designed and synthesized, which could be used for H2S detection and simultaneously type I and type II PDT. TSPy-SS-P had excellent selectivity and anti-interference abilities for endogenous and exogenous H2S detection in tumor cells. TSPy-SS-P was able to distinguish tumor cells with high level of H2S from normal cells by fluorescence “turn off” response to H2S. In addition, TSPy-SS-P showed type Ⅰ and type Ⅱ reactive oxygen species (ROS) generation ability to effectively ablate hypoxic tumor cells. TSPy-SS-P showed mitochondria targeting capacity which could produce ROS in situ to disrupt mitochondria and promote cell apoptosis. In vivo PDT experiments showcased that TSPy-SS-P had excellent tumor retention capability, effective tumor ablation ability and good biocompatibility. This work provided a two-pronged strategy to design organelles targeted photosensitizers for H2S detection and effective PDT of tumors.
资助项目	Zhejiang Provincial Natural Science Foundation of China[LY24H180004];Wenzhou Science and Technology Bureau[S20220020];
ISSN	0039-9140
EISSN	1873-3573
卷号	282
DOI	10.1016/j.talanta.2024.127074
收录类别	SCOPUS ; PUBMED
URL	查看原文
PubMed ID	39432959
SCOPUSEID	2-s2.0-85206827906
通讯作者地址	[Quan, Yun-Yun]School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China ; [Huang, Zu-Sheng]School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China ; [Luo, Yanshu]College of Chemistry and Materials Engineering,Wenzhou University,Wenzhou,325035,China
Scopus学科分类	Analytical Chemistry
SCOPUS_ID	SCOPUS_ID:85206827906
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/220919
专题	药学院（分析测试中心）其他_附属象山医院（象山县第一人民医院）其他_附属萧山医院（杭州市萧山区第一人民医院）
通讯作者	Luo, Yanshu; Huang, Zu-Sheng; Quan, Yun-Yun
作者单位	1.School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China; 2.The Affiliated Xiangshan Hospital of Wenzhou Medical University: Xiangshan First People's Hospital Medical and Health Group,Xiangshan,315700,China; 3.College of Chemistry and Materials Engineering,Wenzhou University,Wenzhou,325035,China; 4.Huadu District People's Hospital,Southern Medical University,Guangdong,Guangzhou,510530,China
第一作者单位	附属萧山医院（杭州市萧山区第一人民医院）; 附属象山医院（象山县第一人民医院）
通讯作者单位	药学院（分析测试中心）
第一作者的第一单位	附属萧山医院（杭州市萧山区第一人民医院）
推荐引用方式 GB/T 7714	Shi, Jizhong,Liang, Manshan,Qiu, Yiting,et al. Two-pronged strategy: A mitochondria targeting AIE photosensitizer for hydrogen sulfide detection and type I and type II photodynamic therapy[J]. Talanta,2025,282.
APA	Shi, Jizhong., Liang, Manshan., Qiu, Yiting., Zhang, Jin., Wang, Shihua., ... & Quan, Yun-Yun. (2025). Two-pronged strategy: A mitochondria targeting AIE photosensitizer for hydrogen sulfide detection and type I and type II photodynamic therapy. Talanta, 282.
MLA	Shi, Jizhong,et al."Two-pronged strategy: A mitochondria targeting AIE photosensitizer for hydrogen sulfide detection and type I and type II photodynamic therapy".Talanta 282(2025).