Comparison of the ED50 of Ciprofol Combined With or Without Fentanyl for Laryngeal Mask Airway Insertion in Children: A Prospective, Randomized, Open-Label, Dose-Response Trial

doi:10.2147/DDDT.S466603

科研成果详情

题名	Comparison of the ED50 of Ciprofol Combined With or Without Fentanyl for Laryngeal Mask Airway Insertion in Children: A Prospective, Randomized, Open-Label, Dose-Response Trial
作者	Wang, Sicong; Li, Yan; Chen, Fang; Liu, Hua-Cheng; Pan, Lezhou; Shangguan, Wangning
发表日期	2024
发表期刊	DRUG DESIGN DEVELOPMENT AND THERAPY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	ciprofol laryngeal mask airway pediatric anesthesia 50% effective dose
其他关键词	PROPOFOL REQUIREMENT ; ANESTHESIA ; INDUCTION ; DESIGN ; PAIN
摘要	Purpose: This study aimed to estimate the effect of different doses of fentanyl on the median effective dose (ED50) of ciprofol for attenuating the airway and motor response to laryngeal mask airway (LMA) insertion response in healthy children. Patients and Methods: 90 healthy preschool patients undergoing inguinal hernia repair surgery were randomly assigned to one of three groups: C0 (ciprofol+saline), C1 (ciprofol + fentanyl 1 mu g/kg), C2 (ciprofol + fentanyl 2 mu g/kg). Anesthesia was induced with either prepared fentanyl or saline, followed by ciprofol. The dose of ciprofol for each patient was determined using the up-and-down sequential study design. The primary outcome was the ED50 of ciprofol required for smooth LMA insertion in the three groups. Additionally, the time to loss of consciousness and any perioperative adverse events were recorded. Results: Compared with the C0 group, the ED50 (95% confidence interval) of ciprofol in the C1 and C2 groups were significantly lower (1.81 [1.73- 1.90]mg/kg versus 0.67 [0.64- 0.71]mg/kg and 0.48 [0.42- 0.54] mg/kg, respectively; P< 0.05). Additionally, the ED50 of ciprofol in the C2 group was lower than that in the C1 group (0.42 [0.42- 0.54] mg/kg vs 0.67 [0.64- 0.71]mg/kg; P< 0.05). Furthermore, the time to loss of consciousness in the C1 and C2 groups decreased by 60% and 53%, respectively, compared to the C0 group. There were no significant differences in the incidence of drug-related hypotension after anesthesia induction among the three groups. No adverse events of hypoxia, bradycardia, or injection pain were observed in any groups. Conclusion: In healthy, non-obese Chinese children undergoing elective inguinal hernia repair surgery, fentanyl 1 mu g/kg and 2 mu g/kg before ciprofol injection significantly reduced the ED50 of ciprofol for attenuating LMA response, with minimal occurrence of severe side effects.
资助项目	Clinical Research Fund of the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University [SAHoWMU-CR2017-03-208]; Science & Technology projects from Science & Technology Bureau of Wenzhou City [Y20210125, Y20210185]; Zhejiang Provincial Health Commission [2022KY208]
出版者	DOVE MEDICAL PRESS LTD
ISSN	1177-8881
卷号	18 页码:4471-4480
DOI	10.2147/DDDT.S466603
页数	10
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:001330886100001
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	39391355
通讯作者地址	[Shangguan, Wangning]Wenzhou Med Univ, Affiliated Hosp & Yuying Childrens Hosp 2, Dept Anesthesiol & Perioperat Med, Key Lab Pediat Anesthesiol,Minist Educ, Wenzhou, Zhejiang, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/220791
专题	第二临床医学院，附属第二医院、育英儿童医院_麻醉学_麻醉科
通讯作者	Shangguan, Wangning
作者单位	Wenzhou Med Univ, Affiliated Hosp & Yuying Childrens Hosp 2, Dept Anesthesiol & Perioperat Med, Key Lab Pediat Anesthesiol,Minist Educ, Wenzhou, Zhejiang, Peoples R China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院_麻醉学_麻醉科
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院_麻醉学_麻醉科
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院_麻醉学_麻醉科
推荐引用方式 GB/T 7714	Wang, Sicong,Li, Yan,Chen, Fang,et al. Comparison of the ED50 of Ciprofol Combined With or Without Fentanyl for Laryngeal Mask Airway Insertion in Children: A Prospective, Randomized, Open-Label, Dose-Response Trial[J]. DRUG DESIGN DEVELOPMENT AND THERAPY,2024,18:4471-4480.
APA	Wang, Sicong, Li, Yan, Chen, Fang, Liu, Hua-Cheng, Pan, Lezhou, & Shangguan, Wangning. (2024). Comparison of the ED50 of Ciprofol Combined With or Without Fentanyl for Laryngeal Mask Airway Insertion in Children: A Prospective, Randomized, Open-Label, Dose-Response Trial. DRUG DESIGN DEVELOPMENT AND THERAPY, 18, 4471-4480.
MLA	Wang, Sicong,et al."Comparison of the ED50 of Ciprofol Combined With or Without Fentanyl for Laryngeal Mask Airway Insertion in Children: A Prospective, Randomized, Open-Label, Dose-Response Trial".DRUG DESIGN DEVELOPMENT AND THERAPY 18(2024):4471-4480.