Causal pathways in lymphoid leukemia: the gut microbiota, immune cells, and serum metabolites

doi:10.3389/fimmu.2024.1437869

科研成果详情

题名	Causal pathways in lymphoid leukemia: the gut microbiota, immune cells, and serum metabolites
作者	Zhuang, Xin1; Yin, Qingning 2; Yang, Rong 1; Man, Xiaoying1; Wang, Ruochen1; Geng, Hui 2; Shi, Yifen1,2,3
发表日期	2024-09-16
发表期刊	FRONTIERS IN IMMUNOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	gut microbiota immune cells lymphocytic leukemia Mendelian randomization analysis serum metabolites
其他关键词	ACUTE LYMPHOBLASTIC-LEUKEMIA ; MENDELIAN RANDOMIZATION ; RATES
摘要	Background We employed Mendelian randomization (MR) to investigate the causal relationship between the gut microbiota and lymphoid leukemia, further exploring the causal relationships among immune cells, lymphoid leukemia, and potential metabolic mediators.Methods We utilized data from the largest genome-wide association studies to date, encompassing 418 species of gut microbiota, 713 types of immune cells, and 1,400 serum metabolites as exposures. Summary statistics for lymphoid leukemia, acute lymphocytic leukemia (ALL), and chronic lymphocytic leukemia (CLL) were obtained from the FinnGen database. We performed bidirectional Mendelian analyses to explore the causal relationships among the gut microbiota, immune cells, serum metabolites, and lymphoid leukemia. Additionally, we conducted a two-step mediation analysis to identify potential intermediary metabolites between immune cells and lymphoid leukemia.Results Several gut microbiota were found to have causal relationships with lymphoid leukemia, ALL, and CLL, particularly within the Firmicutes and Bacteroidetes phyla. In the two-step MR analysis, various steroid hormone metabolites (such as DHEAS, pregnenolone sulfateprogestogen derivatives, and androstenediol-related compounds) were identified as potential intermediary metabolites between lymphoid leukemia and immune cells. In ALL, the causal relationship between 1-palmitoyl-2-docosahexaenoyl-GPE (16:0/22:6) and ALL was mediated by CD62L-plasmacytoid DC%DC (mediated proportion=-2.84%, P=0.020). In CLL, the causal relationship between N6,n6,n6-trimethyllysine and CLL was mediated by HLA DR+ CD8br AC (mediated proportion=4.07%, P=0.021).Conclusion This MR study provides evidence supporting specific causal relationships between the gut microbiota and lymphoid leukemia, as well as between certain immune cells and lymphoid leukemia with potential intermediary metabolites.
资助项目	Natural Science Foundation of Zhejiang Province [LQ19H080002]; Public Welfare Science and Technology Project of Wenzhou [Y20190119, Y20220028, Y20240077]; Zhejiang Provincial Clinical Research Center for Hematological Disorders
出版者	FRONTIERS MEDIA SA
ISSN	1664-3224
卷号	15
DOI	10.3389/fimmu.2024.1437869
页数	19
WOS类目	Immunology
WOS研究方向	Immunology
WOS记录号	WOS:001321365400001
收录类别	SCIE
PubMed ID	39351228
通讯作者地址	[Shi, Yifen]Wenzhou Med Univ, Affiliated Hosp 1, Dept Hematol, Wenzhou, Peoples R China. ; [Geng, Hui;Shi, Yifen]Qinghai Prov Women & Childrens Hosp, Dept Vice President, Xining, Qinghai, Peoples R China. ; [Shi, Yifen]Zhejiang Prov Clin Res Ctr Hematol Disorders, Wenzhou, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/220731
专题	附属第一医院附属第一医院_血液内科
通讯作者	Geng, Hui; Shi, Yifen
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Hematol, Wenzhou, Peoples R China; 2.Qinghai Prov Women & Childrens Hosp, Dept Vice President, Xining, Qinghai, Peoples R China; 3.Zhejiang Prov Clin Res Ctr Hematol Disorders, Wenzhou, Peoples R China
第一作者单位	附属第一医院; 血液内科
通讯作者单位	附属第一医院; 血液内科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhuang, Xin,Yin, Qingning,Yang, Rong,et al. Causal pathways in lymphoid leukemia: the gut microbiota, immune cells, and serum metabolites[J]. FRONTIERS IN IMMUNOLOGY,2024,15.
APA	Zhuang, Xin., Yin, Qingning., Yang, Rong., Man, Xiaoying., Wang, Ruochen., ... & Shi, Yifen. (2024). Causal pathways in lymphoid leukemia: the gut microbiota, immune cells, and serum metabolites. FRONTIERS IN IMMUNOLOGY, 15.
MLA	Zhuang, Xin,et al."Causal pathways in lymphoid leukemia: the gut microbiota, immune cells, and serum metabolites".FRONTIERS IN IMMUNOLOGY 15(2024).