Synergistic activity of Enterococcus Faecium-induced ferroptosis via expansion of IFN-γ+CD8+ T cell population in advanced hepatocellular carcinoma treated with sorafenib

doi:10.1080/19490976.2024.2410474

科研成果详情

题名	Synergistic activity of Enterococcus Faecium-induced ferroptosis via expansion of IFN-γ+CD8+ T cell population in advanced hepatocellular carcinoma treated with sorafenib
作者	Yu, Haitao 1,2,3; Lin, Ganglian1,2,3; Jiang, Junyan 4; Yao, Jiangqiao1,2,3; Pan, Zhenyan1,2,3; Xie, Haonan1,2,3; Bo, Zhiyuan1,2,3; He, Qikuan1,2,3; Yang, Jinhuan1,2,3; Chen, Ziyan 1,2,3; Li, Jiacheng1,2,3; Wang, Yi5; Yu, Zhengping1; Assaraf, Yehuda G.6; Chen, Gang1,2,3
发表日期	2024-12-31
发表期刊	GUT MICROBES 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Hepatocellular carcinoma sorafenib gut microbiota IFN-gamma(+)CD8(+) T cell ferroptosis
其他关键词	ANTITUMOR IMMUNITY ; MICROBIOME ; MODULATION ; EFFICACY ; CANCER
摘要	The gut microbiota plays an important role in the development and treatment of hepatocellular carcinoma (HCC). However, the implication of specific gut microbiota in targeted sorafenib therapy for advanced HCC and the microbiota mode of action, remain to be elucidated. Here, we confirmed that four bacterial genera, Lachnoclostridium, Lachnospira, Enterobacter and Enterococcus, are associated with the therapeutic efficacy of Sorafenib, and that Enterobacter faecium (Efm) plays a crucial role in modulating the sorafenib activity. The effective colonization by Emf induced the IL-12 and IFN-gamma production and an increased proportion of IFN-gamma(+)CD8(+) T cells in the tumor microenvironment. Finally, exopolysaccharides (EPS) from Efm were the primary inducer to prompt IFN-gamma(+)CD8(+) T cells to secrete IFN-gamma, which together with sorafenib instigated ferroptosis in HCC cells. Collectively, these results indicate that Efm is a promising probiotics that enhances the efficacy of sorafenib treatment in advanced HCC.
资助项目	National Natural Science Foundation of China [81703310, 81772628]; National College Students Innovation Entrepreneurship Training Program [202110343054X]; Research Foundation of National Health Commission of China- Major Medical and Health Technology Project for Zhejiang Province [WKJ-ZJ-1706]; Science and Technology Plan Project of Wenzhou Municipality [Y2020153]
出版者	TAYLOR & FRANCIS INC
ISSN	1949-0976
EISSN	1949-0984
卷号	16 期号:1
DOI	10.1080/19490976.2024.2410474
页数	21
WOS类目	Gastroenterology & Hepatology ; Microbiology
WOS研究方向	Gastroenterology & Hepatology ; Microbiology
WOS记录号	WOS:001326683000001
收录类别	SCIE
PubMed ID	39353096
通讯作者地址	[Chen, Gang]Wenzhou Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Wenzhou 32500, Zhejiang, Peoples R China. ; [Assaraf, Yehuda G.]Technion Israel Inst Technol, Dept Biol, Fred Wyszkowski Canc Res Lab, IL-3200003 Haifa, Israel.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/220725
专题	附属第一医院公共卫生学院附属第一医院_肝胆外科阿尔伯塔学院
通讯作者	Assaraf, Yehuda G.; Chen, Gang
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Wenzhou 32500, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Key Lab Diag & Treatment Severe Hepatopancreat Dis, Wenzhou, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 1, Zhejiang Germany Interdisciplinary Joint Lab Hepat, Wenzhou, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Alberta Inst, Wenzhou, Zhejiang, Peoples R China; 5.Wenzhou Med Univ, Sch Publ Hlth & Management, Dept Epidemiol & Biostat, Wenzhou, Zhejiang, Peoples R China; 6.Technion Israel Inst Technol, Dept Biol, Fred Wyszkowski Canc Res Lab, IL-3200003 Haifa, Israel
第一作者单位	附属第一医院; 肝胆外科
通讯作者单位	附属第一医院; 肝胆外科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Yu, Haitao,Lin, Ganglian,Jiang, Junyan,et al. Synergistic activity of Enterococcus Faecium-induced ferroptosis via expansion of IFN-γ+CD8+ T cell population in advanced hepatocellular carcinoma treated with sorafenib[J]. GUT MICROBES,2024,16(1).
APA	Yu, Haitao., Lin, Ganglian., Jiang, Junyan., Yao, Jiangqiao., Pan, Zhenyan., ... & Chen, Gang. (2024). Synergistic activity of Enterococcus Faecium-induced ferroptosis via expansion of IFN-γ+CD8+ T cell population in advanced hepatocellular carcinoma treated with sorafenib. GUT MICROBES, 16(1).
MLA	Yu, Haitao,et al."Synergistic activity of Enterococcus Faecium-induced ferroptosis via expansion of IFN-γ+CD8+ T cell population in advanced hepatocellular carcinoma treated with sorafenib".GUT MICROBES 16.1(2024).