Protective role of ghrelin against 6PPD-quinone-induced neurotoxicity in zebrafish larvae ( Danio rerio) ) via the GHSR pathway

doi:10.1016/j.ecoenv.2024.117031

科研成果详情

题名	Protective role of ghrelin against 6PPD-quinone-induced neurotoxicity in zebrafish larvae ( Danio rerio) ) via the GHSR pathway
作者	Huang, Zhengwei 1,2,3; Chen, Congcong 2,3; Guan, Kaiyu 4; Xu, Shengnan 5; Chen, Xiaoyu1; Lin, Yihao 1; Li, Xi2,3; Shan, Yunfeng1
发表日期	2024-10-15
发表期刊	Ecotoxicology and Environmental Safety 影响因子和分区
语种	英语
原始文献类型	Article
关键词	6PPD-quinone Ghrelin Transcriptomic Zebrafish larvae
其他关键词	METABOLISM
摘要	The toxicity mechanisms of N-(1,3-dimethylbutyl)-N '-phenyl-p-phenylenediamine quinone (6PPD-Q), an antioxidant derivative of 6PPD via ozone reaction commonly used in rubber and tire industries, were investigated in zebrafish larvae with concentrations ranging from 0 to 50 mu g/L. Despite normal hatchability, 6PPD-Q exposure led to reduced body length and swimming distance in 120 hours post-fertilization (hpf) larvae. At the highest concentration (50 mu g/L), 6PPD-Q significantly impaired dopaminergic neuron development and neurotransmitter levels, including dopamine, 5-hydroxytryptamine, and glutamate. Transcriptome profiling unveiled perturbations in growth and developmental gene expression, such as upregulation of runx2a, runx2b, and ghrl (ghrelin and obestatin prepropeptide), and downregulation of stat1b, auto1, and cidea. Notably, anamorelin, a growth hormone secretagogue receptor (GHSR) agonist, recovered the behavioral deficits induced by 6PPD-Q, implying a neuroprotective role of ghrelin possibly mediated via the ghrelin/GHSR pathway. Collectively, our findings indicate that ghrelin upregulation may counteract 6PPD-Q toxicity in zebrafish larvae, shedding light on potential therapeutic avenues for mitigating the adverse effects of this antioxidant byproduct.
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
ISSN	0147-6513
EISSN	1090-2414
卷号	285
DOI	10.1016/j.ecoenv.2024.117031
页数	8
WOS类目	Environmental Sciences ; Toxicology
WOS研究方向	Environmental Sciences & Ecology ; Toxicology
WOS记录号	WOS:001332626000001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	39341137
SCOPUSEID	2-s2.0-85204930611
通讯作者地址	[Li, Xi]Wenzhou Med Univ, Zhejiang Provivcial Clin Res Ctr Mental Disorders, Affiliated Kangning Hosp, 1 Shengjin Rd, Wenzhou 325000, Peoples R China. ; [Shan, Yunfeng]Wenzhou Med Univ, Affiliated Hosp 1, South Baixiang St, Wenzhou 325000, Peoples R China.
Scopus学科分类	Pollution;Public Health, Environmental and Occupational Health;Health, Toxicology and Mutagenesis
SCOPUS_ID	SCOPUS_ID:85204930611
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/220690
专题	附属第一医院附属第二医院附属第一医院_肝胆外科第二临床医学院、附属第二医院、育英儿童医院其他_附属康宁医院（温州市康宁医院）
通讯作者	Li, Xi; Shan, Yunfeng
作者单位	1.Wenzhou Med Univ, Dept Gastroenterol & Hepatol, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Affiliated Kangning Hosp, Zhejiang Prov Clin Res Ctr Mental Disorders, Wenzhou 325000, Zhejiang, Peoples R China; 3.Wenzhou Univ, Coll Life & Environm Sci, Wenzhou 325035, Zhejiang, Peoples R China; 4.Peking Univ, Hosp 6, Inst Mental Hlth, NHC Key Lab Mental Hlth,Natl Clin Res Ctr Mental D, Beijing, Peoples R China; 5.Wenzhou Med Univ, Affiliated Hosp 2, Wenzhou, Zhejiang, Peoples R China
第一作者单位	附属第一医院; 肝胆外科; 附属康宁医院（温州市康宁医院）
通讯作者单位	附属康宁医院（温州市康宁医院）; 附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Huang, Zhengwei,Chen, Congcong,Guan, Kaiyu,et al. Protective role of ghrelin against 6PPD-quinone-induced neurotoxicity in zebrafish larvae ( Danio rerio) ) via the GHSR pathway[J]. Ecotoxicology and Environmental Safety,2024,285.
APA	Huang, Zhengwei., Chen, Congcong., Guan, Kaiyu., Xu, Shengnan., Chen, Xiaoyu., ... & Shan, Yunfeng. (2024). Protective role of ghrelin against 6PPD-quinone-induced neurotoxicity in zebrafish larvae ( Danio rerio) ) via the GHSR pathway. Ecotoxicology and Environmental Safety, 285.
MLA	Huang, Zhengwei,et al."Protective role of ghrelin against 6PPD-quinone-induced neurotoxicity in zebrafish larvae ( Danio rerio) ) via the GHSR pathway".Ecotoxicology and Environmental Safety 285(2024).